New approach limits damage after heart attack and improves survival, say Scripps Research scientists
...ical trial in the second half of 2004 for patients undergoing an acute heart attack. In addition to Cheresh and Weis, the team included scientists from St. Elizabeth's Medical Center at Tufts University School of Medicine in Boston, Massachusetts; the Department of Radiology at Beth Israel Deaconess Medical C...Scripps scientists describe dangerous cocktail of alcohol, brain peptides, and neurotransmitters
...ajor cause of relapse to alcoholism in individuals undergoing treatment. Previous studies have also shown that alcohol enhances GABA neurotransmission in the amygdala, the so-called pleasure center of the brain. Interestingly, the brain corticotropin releasing factor (CRF) stress system also increases G...Hunter receives two major cancer awards
...ific tyrosine kinases. Many of these drugs are now undergoing clinical trials, and one -- a drug called Gleevec -- has been approved to treat a specific type of leukemia. "I'm honored to have received these prestigious awards," said Hunter. "I hope that this recognition underscores the vital importance of basic...Tony Hunter and Raymond N. DuBois awarded Landon-AACR Prizes for Cancer Research
...y of tyrosine kinases. Many of these drugs are now undergoing clinical trials, and one Gleevec has been approved for treatment of chronic myelogenous leukemia. "I'm honored to have received this prestigious award from the Landon Foundation and the AACR," said Hunter. "I hope that this recognition underscores...U Iowa study identifies damaging mechanism in transplants and heart attacks
... in patients at risk of a heart attack - a patient undergoing angioplasty, for example potentially could benefit those patients in the event of a heart attack. In addition to the animal experiments, the UI team also used gene therapy to manipulate the activation of NF-kB. These experiments helped reveal the di...Mastectomy dramatically reduces breast cancer risk among women with BRCA1/2 mutations
...g oophorectomy. The second study shows that women undergoing prophylactic oophorectomy (removal of ovaries) can...titute, and senior author of both studies. "Women undergoing this procedure should feel confident that if they choose this risk management option, it will reduce...Patients give nod to kidney dialysis at home
...uggests that the vast majority of patients who are undergoing hemodialysis could be making a decision on dialysi...t may be part of the reason that more patients are undergoing hemodialysis. The researchers undertook the study because they were puzzled that the rate of using...Story tips from the Department of Energys Oak Ridge National Laboratory, February 2004
... The Cray X1 has passed its acceptance test and is undergoing evaluation on a suite of scientific computer progr...n the name of science. Finally, the IBM Cheetah is undergoing an upgrade that will quadruple the speed of messages inside the machine. The hope is that this could...Making new muscle: Researchers in Rome produce a mouse that can regenerate its tissues
...th a form of muscular dystrophy, whose muscles are undergoing steady deterioration. Stem cells are recruited to the tissue and can significantly reverse the process. This study also provides insight into how stem cells lose their generic quality and become specialized. Some researchers have maintained that upon...New advance to combat antibiotic-resistant pneumonia and malaria
...to other immunocompromised patients, such as those undergoing therapy for cancer and organ transplantation. Pneumonia was responsible for more than 61,000 deaths in the US in 2001, according to the National Center for Health Statistics. Appearing in the January 23 Journal of Biological Chemistry, the study ...Parasite's enzyme structure helps address a public health issue
...compromised, like people with HIV/AIDS or patients undergoing chemotherapy. According to the CDC Web site, Cryptosporidium is often found in public water supplies in the U.S. and cannot be easily filtered out or killed by traditional treatments like chlorine. Currently, there is no cure, and available medicine ...Other highlights in the December 17 issue of JNCI
...utropenia (reduced white blood cell count) who are undergoing stem cell transplantation, according to a study of...th febrile neutropenia, including children who are undergoing stem cell transplantation." Contact: Laura Greer, Hospital for Sick Children, 416-813-5046, laura....Plant immune system's 'take two aspirin' gene, offers hope for disease control
... begins to signal other parts of itself that it is undergoing attack. "This leads to long-lasting, broad-spectrum systemic resistance to infections against the initial attacking pathogen and also against other viral, bacterial and fungal pathogens," Klessig says. "Systemic acquired resistance can last throughou...Aspirin use safe and effective in patients with abnormal red cell counts (or with polycythemia)
...sk of thrombosis in polycythemic patients who were undergoing standard cytoreductive treatments (therapies aimed at reducing the number of blood cells). Treatment with aspirin lowered the risk of cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, pulmonary embolism, and venous thrombosis....New advances in thrombosis help further understanding of disease prevention
...drug and may help to reduce thrombosis in patients undergoing major orthopedic surgery." Patients undergoing elective primary total knee replacement surgery were randomly assigned to one of four dose groups fo...Novel therapies show promise against myeloid leukemia
..., has become the standard therapy for patients not undergoing stem cell transplantation. In newly diagnosed patients, researchers are still uncertain about the length of time imatinib should be administered to adequately determine a response. To assist patients and physicians in weighing the risks and benefit...Origin of multiple myeloma found in rare stem cell
...he myeloma stem cell." Therapies for myeloma undergoing study at the Johns Hopkins Kimmel Cancer Center include antibodies that target the stem cells and drugs to make them age prematurely. Cancer stem cells have been found as the culprit in chronic myeloid leukemia, and the scientists believe the same p...Gastrointestinal specialists comment on new study on 'Virtual' colonoscopy
...t of patients (in some studies higher percentages) undergoing virtual colonoscopy will require conventional colonoscopy to remove polyps 6mm or larger. Dr. Rex added, "Thus virtual colonoscopy is a diagnosis-only test, whereas conventional colonoscopy remains the only strategy that allows both diagnosis and t...Scientists uncover novel role for estrogen in bone marrow
...s those with anemia, bone marrow abnormalities, or undergoing chemotherapy, may benefit from the administration of estradiol and/or a 3b-HSD activator, as an alternative to blood transfusions to increase platelet levels. Conversely, patients with abnormally high platelet counts, who are prone to forming clots a...Proteins may help identify patients who will respond better to treatments in certain cancers
... of 66 percent at five years was seen for patients undergoing an accelerated version of radiotherapy (CHART), compared with a 33 percent success rate in patients undergoing conventional therapy. High through-put molecular diagnosis of gliomas using direct-tissue MALDI-MS a...