Investigational cancer drug prevents abnormal brain growth, reverses seizures in lab mice
...demy of Sciences. In addition, CCI-779 is already undergoing clinical trials for the treatment of cancer, and the current study suggests additional uses for this drug. "Our findings have direct relevance to understanding the biological basis of a variety of human disorders caused by Pten deficiency," Baker sa...Complement inhibitor decreases heart attacks and death in men following cardiac surgery
...ed harmful complement-mediated inflammation in men undergoing cardiac surgery involving cardiopulmonary by-pass ...double-blind study enrolled 564 high-risk patients undergoing open heart surgery, who received a single intravenous dose of TP10 immediately prior to cardiopulmon...Common genetic damages in non-dividing cells lead to the creation of mutant proteins
...netic damages that occur in all non-dividing cells undergoing transcription the everyday activity in which cells produce the proteins necessary to carry out bodily processes. The vast majority of scientists studying genetic mutations have focused instead on the cell replication process, in which damaged and u...Re-engineered blood vessels show promise for bypass surgery, grafts, UMHS researchers find
...ique are in cardiac surgery. For example, patients undergoing coronary artery bypass might benefit from tissue engineered donor vessels. For people receiving bypass surgery or a tissue transfer after an injury, surgeons often harvest blood vessels from the leg, sternum or arm. But taking tissue from these areas...Research collaboration identifies gene essential to puberty
...alled GPR54 that prevent both humans and mice from undergoing normal puberty and sexual maturation. This gene makes a receptor protein that probably is a key trigger of the hormonal cascade required for mammalian reproduction. The discovery could lead to new infertility treatments or contraceptive options, am...JCI table of contents, 15 October, 2003
...h as those with HIV or organ transplant recipients undergoing immunosuppressive drug therapy. Using a mouse model of histoplasmosis, Joshua Nosanchuk and colleagues from Albert Einstein College of Medicine in New York have identified monoclonal antibodies that targeted the histone H2B-like protein of H. capsula...Stanford research finds gene variations that alter antidepressant side effects
...ndings may lead to fewer side effects for patients undergoing antidepressant drug therapy. "Antidepressants are among the most widely prescribed medications in the world," said lead author Greer Murphy Jr., MD, PhD, associate professor of psychiatry and behavioral sciences. "One of the mysteries at this point i...Earliest European modern humans found
...cial skeleton and a partial braincase -- are still undergoing analysis, but are likely to be the same age. The j...leton, temporal bone and other pieces that are now undergoing analysis. Since then, Trinkaus and Moldovan have assembled an international team to document and e...Genetic differences revealed by SNPS play a role in risk, prevention and outcome for cancer
...y a strong risk factor for breast cancer -- when undergoing estrogen and progestin therapy (EPT). Mammograms used in the study were obtained from 233 postmenopausal women aged 45-75 years who had participated in randomized trials with EPT, estrogen alone or a placebo. individuals who might respond better...Lens replacement material may improve cataract treatment, eliminate bifocals
...or other lens replacement surgery so that patients undergoing the operation would not require stitches. The researchers expect to begin animal testing early next year. What they reported to the American Chemical Society was work that involved mechanical and physical testing of the hydrogel that was done in th...... Canberra hopes it has created. Its agent could be undergoing contained field trials in Australia within two years, and be commercially available within five. But there's a catch. The agent in question is a genetically modified virus designed to replicate and spread. It is a new, man-made disease, one of severa...JCI Table of Contents, 15 August 2003
... epithelial cells within the kidney are capable of undergoing epithelial to mesenchymal transition (known as EMT), the process of transformation from epithelial cells to matrix-producing fibroblasts, that may ultimately result in renal interstitial fibrosis and renal failure. EMT is regulated by numerous hormon...Hydrothermal vent systems could have persisted millions of years, incubated life
...ays, is that fracturing also happens because rocks undergoing serpentinization increase in volume 20 percent to 40 percent. Kelley likens it to water seeping into tiny cracks in roads, then freezing and expanding to cause ruts and frost heaves in the pavement. Scientists think many Lost City-type systems were...Blood tests identify patients on dialysis at high risk for death from cardiovascular disease
...sts or interventions such as bypass surgery before undergoing a kidney transplant, for the best outcome," says d...r the interpretation of troponin tests in patients undergoing dialysis. "Clinicians weren't sure what to make of results that suggested the presence of cardiovasc...Newly invented Endometrial Function Test (EFT®) solves the puzzle of unexplained infertility
...83 women seeking fertility treatment, and 23 women undergoing mock cycles in preparation for frozen or donor embryo transfer. The researchers compared the expression of cyclin E and p27 in these groups at many different times throughout the menstrual cycle to establish the normal and abnormal patterns of expres...Cyclacel's biomarker technology shows that CYC202 induces cancer cells to commit suicide
...d a baseline for quantifying apoptosis in patients undergoing CYC202 monotherapy, we can use such biomarker techniques to assess the effects of the drug on patients receiving CYC202 in combination with chemotherapy." "The results presented at AACR confirm Cyclacel's technological leadership in the emerging fiel...ART laws put patients at risk and should be changed, warns head of Germany's IVF registry
...the pronuclear stage, women have to choose between undergoing one round of IVF treatment in which the maximum number of embryos are implanted in the hope that at least one of the embryos is good quality, or to undergo the time, expense and medical problems (such as ovarian hyperstimulation syndrome) associated ...First study of children born after in vitro maturation indicates the technique is safe
...mones to help them to become pregnant, but who are undergoing IVF because their partners have impaired sperm; and for women with polycystic ovarian syndrome [1] who are at an increased risk of developing ovarian hyperstimulation syndrome [2] during IVF hormone treatment. Between July 1998 and January 2002, 33...Spanish fertility experts bring hope of avoiding serious complication of assisted reproduction
...tes and oedema. The research team studied 50 women undergoing controlled ovarian hyperstimulation with hormones at different times in their ART cycle. They found that, compared with a control group, women who developed severe OHSS had a four-fold increase in their serum VE-cadherin levels after they had receive...New research challenges advice that men should abstain from sex before fertility treatment
... to a week at least is beneficial for men prior to undergoing some types of fertility treatment. Doctors and scientists from Soroka University and Ben-Gurion University of the Negev, Beer-Sheva, tested over 7,200 semen samples for semen volume, sperm concentration and shape, and the percentage and total count ...