Tag: "underlies" at biology news

Researchers determine genetic cause of Timothy syndrome

...childhood disorder, called Timothy syndrome, which underlies a form of severe cardiac arrhythmia. The research shows that children who have the syndrome develop spontaneous genetic mutations that interfere with calcium channels that regulate the excitation and contraction of the heart. In defining the precise...

Israeli scientists reveal the plan of a key cellular machine

...itching them together. Alternative splicing, which underlies the huge diversity of proteins in the body by allowing segments of the genetic code to be strung together in different ways, takes place in the spliceosome as well. The team consisted of husband-and-wife scientists Prof. Ruth Sperling of the Geneti...

Study by Israeli scientists provides insight on DNA code

...itching them together. Alternative splicing, which underlies the huge diversity of proteins in the body by allowing segments of the genetic code to be strung together in different ways, takes place in the spliceosome as well. The team consisted of husband-and-wife scientists Prof. Ruth Sperling of the Geneti...

A genetic disorder yields insight into genes and cognition

...to shed light on the neurological malfunction that underlies this inability. In particular, they sought to determine whether the functional disorder could reveal the "modularity" of the processing of visual information in the brain's visual cortex. The visual cortex is basically organized into two processing p...

Streptococcus infects humans by thwarting blood clotting

...city factors, not just streptokinase, and probably underlies the species-specificity of all kinds of infectious organisms," said Ginsburg. Such findings also hint that subtle variations in plasminogen genes among humans could partially explain differences in susceptibility to certain infection in different peo...

Strep disrupts blood clotting to infect humans

...city factors, not just streptokinase, and probably underlies the species-specificity of all kinds of infectious organisms," Ginsburg said. "The bacterial streptokinase enzyme bypasses this blood-clotting system by causing the blood clot to dissolve so the bacteria can spread," Ginsburg said. Streptokinase sec...

Cell study leap forward for tissue engineering, diseases

...ed scientists," says senior author Winklbauer. "It underlies much of embryonic development and is involved in pathological conditions such a spina bifida, a common birth defect where the spinal cord fails to develop properly." Using tissue from frog embryos, Ninomiya and Winklbauer studied "convergent extens...

JCI table of contents, 1 July 2004

...od The identification of a genetic mechanism that underlies one form of thrombocytopenia, may provide new unde...lelic expression combined with its hemizygous loss underlies Paris-Trousseau/Jacobsen thrombopenia AUTHOR CONTACTS: Remi Favier Hematological Laboratory, Armand...

Donaghue Women's Health Investigator Program awards grants to three at Yale

...birth can contribute to PPD, the neurobiology that underlies this disorder has not been identified. Duman will address this issue by conducting a series of integrated studies in an animal model of PPD. The findings of these studies will be used for expanding research approaches to PPD and for developing nove...

A protein's role in progressive renal disease

...nts; many have waited over five years. FSGS, which underlies about 25% of the 60,000 kidney-related deaths each year, causes progressive kidney failure. FSGS commonly occurs as an outgrowth of various primary disorders, including obesity, HIV infection, diabetes, and hypertension. Though it's not clear what ...

Existing drug may prevent brain injury and seizures in newborns

...age called periventricular leukomalacia (PVL) that underlies cerebral palsy. PVL is most common in the preterm infant and is thought to be caused by excitotoxic damage to oligodendrocytes, cells that produce a substance called myelin. Myelin insulates neurons and enhances signal transmission; without it, neur...

Tamoxifen stimulates breast cancer growth following alteration of estrogen receptor

...r. These results enhance the understanding of what underlies tamoxifen resistance in breast cancer and may eventually allow for earlier identification of resistant tumors, providing critical time to choose an alternative therapeutic strategy that is more likely to be effective. Because nearly three-qu...

Unnatural light-dark cycles expose duelling circadian clocks

...rain and body but also within the SCN itself, that underlies the workings of the circadian timing system. In humans, some of the symptoms arising from jet lag or rotating work schedules might not be due to the desynchronization between the central brain pacemaker and downstream oscillators in the body, but rat...

March of Dimes awards $250,000 prize to pioneering scientist

... research has profoundly advanced the science that underlies the understanding of birth defects. The March of Dimes created the Prize as a tribute to Dr. Jonas Salk shortly before his death in 1995. The March of Dimes Prize will be awarded to Dr. Lyon at a black tie dinner and ceremony on May ...

Searle Scholars program awards $240,000 to UT Southwestern researcher

... calcium, across the cell membrane. Their function underlies many biological processes, including the excitation of nerve and muscle cells, the secretion of hormones, and sensory transduction. An Endowed Scholar in Medical Science at UT Southwestern, Dr. Jiang joined the faculty in 2003. He earned a bache...

Genetic basis of hereditary nerve disorder revealed

...l to mitochondrial movement, known as mitofusin 2, underlies the disease symptoms. Restoring the lost gene function through gene therapy might ultimately serve as an effective treatment for the disorder, which currently has no cure, the researchers reported in the April 4, 2004, issue of Nature Genetics . CMT...

The biological clock: What really makes us tick

...s. By understanding this molecular circuitry that underlies biological rhythm function in the fruit fly (Drosophila melanogaster), Hardin is determining how daily rhythms in physiology and behavior found in many organisms are controlled by an innate, genetically encoded circadian clock. This research has all...

Migraine mouse provides insight into neurobiology of devastating headaches

...al spreading depression (CSD), the phenomenon that underlies the migraine aura. "Previous studies have indicated that CSD is a wave of intense neuronal activity along the surface of the brain, followed by a long-lasting neuronal suppression. Our results suggest that in the migraine brain cortical hyperexcitabi...

Rich genes travel more

...determined or tissue-specific gene regulation, and underlies the heterogeneous distribution of gene expression. The distribution of gene expression can be described using what is known as a "power law" distribution. In such a system, it can be shown that the number of genes having expression level X is 100 tim...

Drug addiction, learning share common brain protein

...icity in one part of the brain to a mechanism that underlies learning and memory in another brain region." Caron is also interim director of the Center for Models of Human Disease, part of Duke's Institute for Genome Sciences and Policy, and James B. Duke professor of cell biology. Previous work by other rese...

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