Newly Discovered Gene Halts Cell Division and May Have Cancer Link
... The researchers suspect that certain genetically unstable breast, ovarian, and prostate tumors may have defects in the gene, known as MAD2. The new discovery may open the door to finding more effective ways to treat such tumors. "We think the MAD2 gene stops cells from dividing when doing so would leave th...Stronger Evidence That Global Climate Change Can Reduce The Variety Of Life
...livingin the abyssal North Atlantic Ocean has been unstable in the face of pastglobal climatic changes. They measured how trends in the biodiversity of fossilizedostracodes varied over a half-million year interval of alternating cold(glacial) and warm (interglacial) climates. The microscopic fossil s...Newly Discovered Human Protein Provides Important Target For Cancer Therapy
...ss reaches a critical stage; the chromosomesbecome unstable and any further cell division leads to cell death. (Thislimited allowance for cell divisions may be a significant factor in normal humanaging.) "Cancer cells find a way of switching telomerase activity on, whichgives them a tremendous compe...New Molecular Switch Is The Key That Unlocks DNA Repair
...Without hMSH2 or hMLH1 the cellular DNA becomes unstable [genome instability], errors accumulate and the result is cancer,” Dr. Fishel explained. In their experiments, the scientists measured the initial binding of hMSH2-hMSH6 to a mismatch of the nucleotides G (guanine) and T (th...Scientists Work To Restore Native Fish And Habitat To Great Lakes
...otic species, such as the sea lamprey, have led to unstable fish communities, a loss of sport fishing opportunities and serious economic impacts," said Dr. Gregory Smith, Acting Eastern Regional Chief Biologist for the USGS. The USGS and the Fish & Wildlife Service are looking at new ways to help restore key ......n are inaccurately diagnosed with a heartattack or unstable angina (chest pain). On the other hand, as many as one-thirdof all heart attacks go unrecognized. Researchers at the University of Pennsylvania Medical Center have shownthat diagnostic accuracy of chest pain can be dramatically increased--up ......and stable while walking. Goats, while nimble, are unstable during the brief times that all their feet are off the ground, the same as humans. The wheelchair has an aluminum frame with the plastic seat from a desk chair mounted on top, two rubber tires in back, and two casters in front. Six motors drive ...Tinkertoy Robot Shows How Humans Walk
...e believe this is the first two-legged, statically unstable 3-D passive-dynamic walker that can walk stably do... kind that is dynamically stable near a statically unstable configuration and doesn't have fast spinning parts," says Ruina. "Playing, with no hopes of success,...Social Stress Shortens Lives Of Monkeys With AIDS
...ficantly better early blood tests than the ones in unstable conditions, Capitanio said. What did predict early...egardless of social condition. In both stable and unstable groups, the monkeys that received the most aggression from other monkeys had the worst blood-test re...Ulcer-Causing Bacteria Also May Be Associated With Heart Disease
...r pylori was similar in patients withheart attack, unstable chest pain, or chronic chest pain," says the study's leadauthor, Vincenzo Pasceri, M.D., of the department of internal medicine andcardiology at the Catholic University of the Sacred Heart in Rome. "The findings strongly suggest that the association ...Study Of Sulfides In Bacteria Casts Doubts On Evidence Of Life In Martian Meteorite ALH84001
...ay actually begin withcubic iron sulfide, which is unstable and rapidly becomes mackinawite. In the geological environment thebacteria are found in, the reaction sequence would also eventually lead to greigite breaking down intopyrite and pyrrhotite, but that reaction does not occur when the bacteria are pres...Vitamin C May Reduce Angina, Heart Attack Risks
...ion ofblood vessels, preventing the chest pains of unstable angina pectoris andreducing the risk of heart atta...vailability is improved, it reducesthe presence of unstable angina pectoris or the risk of coronary eventslinked to a higher level of heart attacks, experts say...Platelet Receptor Biology Is Key To Fighting Heart Disease
... as aggrastat -- could reduce the risk of death in unstable anginapatients by 47%. The drug attaches to and blocks biochemical doorways onplatelet cells called IIb/IIIa receptors. When bound to these receptors, thedrug keeps fibrinogen -- a protein found in the blood -- from adhering toplatelets, thereby prev......imaging technology proves effective in identifying unstable plaque obstructions in the blood vessels, it will provide a way for cardiologists to diagnose people who are at high risk of having a heart attack or stroke and to initiate treatment to help stabilize the plaque obstructions or reduce the chances tha...Cedars-Sinai Scientists Localize New Ataxia/Epilepsy Gene
...t may indicate that thegenetic defect is caused by unstable DNA repeats. In contrast to other inherited ataxias, however, 20 percent of members of thefamily affected by the ataxia suffered seizures. "This connection makesisolation of the genetic defect so exciting", says Dr. Pulst, "because it willlikely she...U-M and Israel launch major international cancer study
...tion to help determine why some people manage this unstable region moresuccessfully than others. Gruber and his colleagues believe there are probably other similar geneticalterations that have yet to be discovered. While most of the geneticalterations that have been discovered appear to increase the risk of ...Key progress by Weizmann scientists in the race to unravel ribosomal structure
...ystallography. However, the ribosome, anotoriously unstable giant protein complex, represents a daunting crystallographic challenge. Tofurther complicate matters, it also lacks the internal symmetry and repetitions that eased the way tounderstanding the structure of other biological entities, such as viruses....'Frozen pictures' allow far-reaching glimpse into the cells protein factory
...interactions. However, the ribosome, a notoriously unstable giant nucleoprotein complex, represents a daunting crystallographic challenge. To further complicate matters, it also lacks the internal symmetry and repetitions that eased the way to understanding the structure of other biological entities, such as ...Immune system chemical may predict worsening of coronary heart disease in women
... exertion or after exercise, and the remainder had unstable angina-the same symptoms, but occurring unpredicta...cer and viral infections. Twice as many women with unstable angina sustained major clinical events, and their levels of neopterin were significantly higher than...DNA details suggest how human chromosomes break, rearrange and cause a genetic disease
...bnormal palate. The researchers described unusual, unstable DNA structures in parents of children with the dis...e model draws on the fact that in other organisms, unstable palindromic DNA sequences are inclined to protrude from the famous DNA double helix in fragile struc...