A novel, safer strategy for regulating gene expression
... protein could trigger the immune system and cause unwanted side effect. In addition, the current systems work with only a handful of specific drugs. In contrast, the ribozyme-based system can, in principle, be designed to regulate genes using any drug, or any chemical change in the body. The system is also e...Peering inside the body, with a new spinliterally
...rce? The problem with slow MAS is that it produced unwanted signals, what Wind and colleagues call "spinning side bands," that obscured the sample's spectra. Wind let the idea percolate for about six years as he worked on a combined NMR-optical microscope other devices at the W.R. Wiley Environmental Molecul...Researchers identify distinctive signature for metastatic prostate cancer
...importance of this pathway, there are questions of unwanted side effects. We have been able to give effective doses of cyclopamine to mice for long periods of time without any obvious detriment. But we have no idea whether there are long-term physiological effects, or whether humans might suffer side effects ...Serotonin metabolites in mollusks suggest pathways for human therapies
... other tissues as well. That potentially leads to unwanted side effects. Stuart, using a detection system built to measure serotonin and related compounds, found two new serotonin metabolites in the nervous system of marine mollusks. The metabolites were in separate yet adjacent body tissues, suggesting, h...The birth of reproductive health: A difficult delivery
...ch obstacles yield sobering statistics: 60 million unwanted pregnancies, 19 million unsafe abortions, and over half a million women dying from complications of pregnancy and childbirth every year. "Getting it right on reproductive health cannot wait another decade," says Dr El Feki. "The largest gene...New fumigant to replace gas that damages ozone layer
... and more effective than methyl bromide in killing unwanted insects, moulds, bacteria and nematodes," says Dr Daly. "This provides CSIRO and BOC with a timely opportunity to create a multimillion dollar market for this new fumigant." BOC Managing Director Graham Smith says, "This agreement continues a lon...Anti-bacterial additive found in Maryland streams
...locarban on aquatic life and potential pathways of unwanted human exposure," said Dr. Halden....Protective gene may enhance vaccine responses
...reduce or eliminate memory T cells responsible the unwanted immune responses that cause autoimmune diseases such as arthritis. Additional authors of the paper include Ni Lui, Tiphanie Phillips, Minling Zhang, Yue Wang, Joseph Opferman and Ramila Shah, all from the University of Chicago. The National Instit...UCSD researchers are first to demonstrate molecular link between inflammation and cancer
... of cell suicide, apoptosis prevents the growth of unwanted cells. It is a normal process the body uses to kill mutated or chemically transformed cells, as well as useful cells that have outlived their purpose. Evading apoptosis is one of the hallmarks of cancer. In their study, the UCSD team found that apop...Mitochondria in spinal cords is ALS target according to UCSD medical researchers
... the body's normal method of disposing of damaged, unwanted or unneeded cells. "We believe that when the mutant SOD1 binds to mitochondria, it affects the ability of these components to generate cell energy," said the study's senior author, Don Cleveland, Ph.D., a UCSD professor of medicine, neurosciences, an...Salmonella infects cells and saves itself by altering host membrane lipids
...ment, the lysozome, designed to degrade foreign or unwanted materials. Once the bacterium is engulfed, it takes only about 30 minutes to reach a lysozome. Therefore, to survive and replicate, bacteria must act rapidly to avoid this pathway to degradation. Salmonella, the bacterium that causes food pois...Nature's ambush: pregnancy more likely from single unprotected intercourse than believed
...protected intercourse is more likely to lead to an unwanted pregnancy than was previously believed. In a study on women who had either been sterilised or were using an intrauterine device (IUD) the frequency of intercourse increased during the six most fertile days of the menstrual cycle and peaked at ovulati...UC Riverside researchers discover new way to identify cell growth
...ostic tool to monitor the emergence of cancer. The unwanted 'awakening' of cells from the dormant phase can result in uncontrolled cell growth that is loosely referred to as cancer. "We have developed a tool (antibody) that detects the novel marker and identifies growing cells," Sauer said. The research pape...When 'reaper' gene comes, cell death follows
...ucing genes could be unloosed to specifically kill unwanted cells--such as tumors. Cell death (apoptosis) begins when ecdysone, a steroid hormone, binds to its receptor, EcR/USP. This binding allows the receptor to activate three key regulatory genes--E93, BR-C, and E74A. Those genes turn on reaper and hid, ...Transplant rejection averted by simple light exposure in Stanford animal study
...gerhans cells in a manner that doesn't cause other unwanted effects," he said....Is a single bout of exercise helpful or harmful in getting a good night's sleep?
...ocate a sensible diet and regular exercise to shed unwanted pounds. Americans are accepting that advice: low-fat meals are the staples of many diets and both sexes are now engaged in an exercise regimen. As evidence of the latter, marketing experts claim that membership growth in health and fitness club facil...Scientists question reports of massive ant supercolonies in California and Europe
... Genetic barriers But introducing more unwanted ants into California is not a solution, say Gordon and her colleagues, arguing that there are major flaws in the supercolony theory. "There's a perception out there in the public eye that Argentine ants cover this wide, uninterrupted swath fr...Freeing Nemo: Aquarium owners releasing non-native fish could endanger marine ecosystems
... provide ways for aquarium owners to sell or trade unwanted fish. ...Bioreactor boosts chemical fermentation by 50 percent: study
... The device also reduced the amount of two unwanted byproducts that normally result from propionic acid fermentation -- cutting one byproduct by more than half, said Shang-Tian Yang, professor of chemical engineering at Ohio State. The bioreactor grows cells inside a bundle of fibers. Yan......ent of the machinery by which the cell breaks down unwanted proteins. "This was a thorough test of the system because there are a great number of different genes whose loss could interfere with proteasome function," said Elledge. "We found quite a few genes, and concluded that the library had worked quite eff...