Abgenix reports positive clinical data with ABX-IL8 in Psoriasis
...kin-8 ("IL-8"), which is a cytokine that can cause unwanted inflammation by first enabling immune cells, including neutrophils, to migrate to inflammatory sites and subsequently activating them. There is substantial evidence that IL-8 contributes to a number of inflammatory diseases, including psoriasis, rheu......n antibody and its target may, for example, reduce unwanted side effects that may occur with other therapies. Fully human antibodies are desirable because they avoid the risk of rejection present with mouse or partial mouse antibodies. Abgenix is a biopharmaceutical company that develops and intends to co...New tool provides major advance for understanding chronic Lyme disease and other illnesses
...ndidate self-antigens and develop ways to turn off unwanted immune responses they might generate. "We are already using this technique in our study of multiple sclerosis," notes Dr. Martin. For the research reported here, the scientists used the T cells found in the patient's spinal fluid to probe for what m...License to kill: development of killer T cells observable
... the cellularmachinery that enables them to attack unwanted cells. "During the initial stages of an HIV infection, there are lots of cytotoxic T cells in the bodybut, for some reason, they are not able to contain the infection," says N. Manjunath, PhD, researchfellow, and lead author of the study. "Is there ......ther females. This would not only save millions of unwanted farm animals every year which are usually discarded, but also enormously increase the productivity of animal farming....Human genome bears a virus related to HIV-1
...ciency virus (HIV). Humans have been carrying this unwanted genetic baggage around for more than 30 million years, according to researchers from the Howard Hughes Medical Institute (HHMI) at Duke University. "We're all walking around with a little bit of an HIV-like sequence in our genes," said Bryan Cullen,...New evidence pushes back age of sex-determining chromosomes
... The flip side of this process is the disposal of unwanted or unneeded geneson the Y chromosome. Genes that are not needed by the male may graduallyaccumulate problematic mutations. In the female, a mutated gene on one Xchromosome can be compensated for by a "healthy" gene on the other X chromosome.In the ma...... agent needed to circumvent this problem result in unwanted sideeffects. Long-term, low-level production of freely circulating nerve growthfactor may be the solution for patients with peripheral neuropathy in arms andlegs resulting from diabetes or exposure to chemotherapy, for instance. Peripheral neuropath...Duke study: Exercise may be just as effective as medication for treating major depression
...ications, and for others, themedications can cause unwanted side effects. Exercise should be considered aviable option." While the researchers studied middle-aged and elderly people, Blumenthal saidthe results probably hold true for the general population. "Because the elderlytend to have additional medical...Response to cocaine linked to biological clock genes
...g Abuse. Fruit flies--recognized by many people as unwanted sentinels of overripebananas--are an extraordinary laboratory tool. Nearly a century of geneticresearch on fruit flies now permits biologists to mix and match fly genes toprobe the function of physiological processes such as nervous system pathways....Enzyme-based method to isolate stem cells from umbilical cord blood shows promise
...nematching is not required, but it's possible that unwanted diseased cells couldbe returned to the patient. The new isolation technique could potentiallyeliminate such problems by making it possible to collect and deliver pure stemcells. If the isolated stem cells work in living systems, the method might als......" Duchenne muscular dystrophy is caused by unwanted alterations in thegene that codes for a large protein called dystrophin, required for muscle cellsto survive the rigors of use. Mutations can occur anywhere in the gene, however,and not all mutations are equal. In about 15 percent of Duchenne patient...Heavy metal research is music to biologists' ears
..., the copper chaperoneprotein protects copper from unwanted cellular interactions and safely deliversit to its destination. The work also identifies a potential target for developing drugs to treat LouGehrig's disease, a uniformly fatal condition. The research report appears in the August 1999 issue of the jo...Scientists find first molecule that guides nerve cells through the brain
...ulsive molecule might beuseful for controlling the unwanted migration of tumor cells or for deliveringtherapeutic cells to specific regions of the brain in patients with Parkinson?sdisease or Alzheimer?s." Rao and Jane Y. Wu, M.B., Ph.D., assistant professor of pediatrics and ofmolecular biology and pharmacol...Scientists target microbe with sleeker antisense agent
...elonger the molecule, the lesser the likelihood of unwanted side effects fromtargeting the wrong RNA strand. Such side effects include rashes, fever andfatigue in AIDS patients, and bone marrow suppression in cancer patients.Turner's team discovered that the molecule could be kept remarkably short andstill bi...Invasive fishes pose increasing threat to U.S. waters and native fishes, says USGS
...others have spread throughreleases of live bait or unwanted aquarium pets, or arrived in ballast waterdischarged from ships. The new book provides detailed information on more than 500 non-native fishspecies, including methods of introduction, ecological and economic impacts,range maps and identification aid...Coffee Without Addiction, Possible New Treatment For Osteoporosis, Wrinkle-Free Cotton, And More
...Butyltincompounds -- used to inhibit the growth of unwanted organisms like algae andused on large ships and in wood preservatives -- have been shown for the firsttime to disrupt the function of human blood cells, called NK or "natural killer"cells, that destroy tumor cells and provide important immune system ...Chemical Contaminants May Inhibit Cancer-Fighting White Blood Cells
...riple forms. They areusedto inhibit the growth of unwanted organisms such as bacteria, algae, andbarnacles. Tributyltin (TBT) is used as a wood preservative as well as on fishculture nets, docks, and boat hull paints. Though TBTs have been banned onsmall boats for about a decade, they are still commonly us...Researchers Find Fas Ligand Is Important In Blinding Disease
... dry form, whilethere is vision loss, there are no unwanted vessels growing beneath the retina." The vessels grow from the choroid, a structure beneath the retina. For10 years, Kaplan and colleagues have attempted to surgically remove abnormalvessels and scar tissue. The limitation of this approach is......nd when it does you canhave a lot of damage. "Such unwanted assembly of protein can occur when the various components are notin complete order. They will still aggregate and form maybe beautifulstructures, but they can be very detrimental. We know some of the resultingdiseases very well," Schulten said. "O...