UB Researcher Developing Method That Employs "Evolution" To Identify New Drug Leads
...nthesized by pharmaceutical scientists are only as useful as the new compounds they generate. A new drug-discovery method being developed by University at Buffalo researchers may be able to turn those chemical libraries, arrays of compounds synthesized in the lab, into molecular "habitats" where only the m...First TableTop Source Of Concentrated X-Rays Built
...dramatically increase their efficiencyto make them useful for applications, such as imaging, Murnane said. Moreover,whereas traditional lasers emit visible and near-infrared light (withwavelengths in the 500-1000 nanometer range), those from the U-M device areabout 20nm, with the possibility of being as sh...After The Wine Is Made, The Rest Of The Grape May Be Good For You
...to a landfill. Meyersuggests that her work may be useful in the commercial exploitation of grapepomace for production of antioxidant concentrates. Grape seed extract isalready widely sold as a nutritional supplement, she says. But she cautionsthat more research is needed to determine the exact physiologi...Study Shows Athletes Get No Kick From Nasal Strips
...w-intensity exercise indicates the strip may prove useful to people who experience exercise-induced asthma, Cerny noted, because a person will breathe longer through the nose if resistance is lower. Nasal breathing allows for better conditioning and warming of inhaled air, a plus for asthma sufferers, he s...EPA And UC Researchers Find Bacteria That Can Destroy Giardia Cysts
... is necessary to see whether the bacteria would be useful indrinking water treatment, perhaps by using the bacteria in waterfilters to degrade the chlorination-resistant Giardia cysts....Crystal Structure Of Key HIV Protein Reveals New Treatment Targets
...table and thereforevulnerable, it could be another useful target for drugs or vaccines. A large "silent face" - a surface that does not react to antibodies and isthus invisible to the immune system. A ball-and-socket interaction: a residue of phenylalanine 43 that sticks outfrom CD4 receptors and fits...Increased Interest In "Smart" Materials Is Reported
...smit or process it, andthen respond by producing a useful effect, such as a signal showing that thesmart mat...etic field, hydrostatic pressure,or the like. The useful effects produced may include changes in color, volume,stress distribution, and index of refraction. ...Taking The "Ouch" Out Of Needles: Arrays Of "Microneedles" Offer New Technique For Drug Delivery
...logy believe theirmicroneedles would be especially useful with large protein-based molecules, suchas those p...nthe body's need. Such a feedback system would be useful in regulating the bloodsugar levels of persons suffering from diabetes, Prausnitz noted. Using reac...New Biomaterial Has 'Star' Power
...y small volume would make these star polymers very useful in biological and pharmaceutical applications, such as delivering a high concentration of drugs throughout the body or to a specific target," Keys says. The star polymer gels Keys developed are made from the polymer polyethylene glycol, or PEG, ...Who Needs Flowers? Transgenic Plants Sprout Embryos On Leaves
...ems of seed development." Harada said LEC1 will be useful in figuring out thecoordination between the early, tissue-building stage ofembryo development and the late, seed-maturing stage. "The LEC1 gene is teaching us a great deal," he said. "Andthe research also has implications for some importantapplicati...A Synthetic Peptide Destroys Brain Plaque Implicated in Alzheimer's Disease
...Dr. Soto. "We also believethat our compound may be useful in treating other diseases caused by defectiveprotein folding, including prion disease and amyotrophic lateral sclerosis orLou Gehrig's disease." Amino acids hook together to form peptides and proteins. Amyloid plaque isdeposited in the brain as ...Scientists ID A Protein With Punch As Infection-Inflammation Fighter
...a. "That's when we began to wonder: Could PR-39 be useful as an inflammationfighter?" he added. Since 1995, the KSU team has acquired collaborators who are extending theresearch from cellular studies to using animal models. PR-39 continues to lookvery promising. Dr. Tom Leto of the National Institutes of He...Ecological Consequences Of Jasmonate-Induced Responses For Plants In Native Populations
...story characteristics that make it particularly useful for a test of the cost-benefit model for induced defenses. It is an ephemeral member of the annual community in burned sagebrush, blackbrush and pinyon-juniper forests of the Great Basin desert and synchronizes its growth with the post-fi...UNC-CH Researchers Develop Promising Heart Research Tool
...e new laboratory tool thatpromises to provide some useful answers. Resulting discoveries eventually could reduce the death rate from themore than 300,000 sudden deaths in the United States each year, the researcherssay. "Our new method, which is an experimental model system, shouldcontribut...Scientists Excited About Miniature Cooking Pots
...e-like structures foryears, thinking they would be useful for making materials ofunique value or materials that would have unique properties,Douglas said. But the results were mixed. The size wasn't alwaysuniform, and hence, neither were the properties. Instead of building the cages one molecule at a time,...Priestly Gene Shared By Widely Dispersed Jews
...ounterparts. The Y-chromosome is uniquely useful in this analysis because theY-chromosome of any individual can be traced back even over many generations toonly one male ancestor. This is not the case for other chromosomes, each ofwhich carries representation from many different ancestors on both t...First Reproducible Cloning Of Mammals From Adult Cells Reported In Nature
...ein-basedpharmaceuticals.The technique may also be useful for cloning wild or endangered speciesin a controlled environment. "Our study validates animal cloning, which we did using an injectionmethod and adult cells. Our method differs substantially from previoustechniques.Earlier procedures generated clon...UF Discovery Of Chicken Gene Mutation Aids Study Of Rare Inherited Eye Disease
...or thechicken will be something that could be very useful in treating people,"Rowland said. Rowland now is developing a form of gene therapy for chickens with thedisease. "The eye offers a unique opportunity to employ gene therapy because itis a closed system," she said. "The cells in the eye are...Atmospheric Chemistry -- A Mysterious Isotope Effect In A Well-Known AtmosphericPollutant Discovered
...n inthe atmosphere may be obtained. Besides these useful applications of the discovered isotope effect, fundamentalquestions concerning reaction mechanisms in the gas phase are raised. At presentit is impossible to explain the cause of the mass-independent isotopefractionation in the reaction of CO with OH......rtunately, this is a destructive pathway thatkills useful adult cells." Penn colleagues John Q. Trojanowski, MD, PhD, professor of pathology andlaboratory medicine, and Ramesh Raghupathi, PhD, research assistant professor inneurosurgery, also collaborated on the study. This research was supported by...