Vanderbilt, Meharry establish new Center for AIDS Research
...imate solution to the worldwide AIDS epidemic is a vaccine that can prevent HIV infection. Vanderbilt is heavily committed to that effort, too. "While we're working toward that long-term goal, (we need to) keep improving therapy so that (AIDS) really can become a controllable disease that will not kill peopl...Pathogenic yeasts and fungi: A growing health concern
...ition, he says, Saccharomyces may be employed as a vaccine delivery vector. Two other potential applications are in the pipeline. Two years ago, Whitehead postdoctoral fellow Mike Lorenz identified a metabolic pathway that's fungal-specific and required for infection. The Institute has applied for a patent ...Immune cells may help deliver cancer vaccines for children
...s. "This response could form the basis of a cancer vaccine that stimulates the body's existing immune system," said Christina M. Coughlin, M.D., Ph.D., who presented the research today at the annual conference of the Pediatric Academic Societies in Seattle. Unlike routine childhood vaccinations such as those...First peer-reviewed SARS genome sequence appears in Science
...eins in diagnostic tests, therapies, or possibly a vaccine for SARS," said Katrina Kelner, Deputy Editor, Life Sciences, at Science . A Canadian team was the first to sequence the genome of a SARS viral strain, taken from a patient in Toronto. Shortly thereafter, a U.S.-based team sequenced the so-called Ur...Researchers discover method of predicting drug resistance in hepatitis-B patients
...n 15-25% of chronically infected persons. The HBV vaccine is the best protection against HBV, which is now routinely administered to infants as part of their standard immunizations. "In an era of skyrocketing medical costs, the cost savings in not treating patients who will not respond may be a profound ...Hollow spheres make solid vaccine to protect fish
BERGEN, Norway-A new kind of vaccine to protect salmon and trout from infectious pancre...eared salmonoids. There is no reliable commercial vaccine available for IPNV, the researchers reported. Scientists of UMBI's Center for Biosystems Res...Microgel polymer beads may provide general vehicle for vaccines, gene therapy
... The polymer beads are imbedded with a protein - a vaccine antigen, for example - and made large enough to attract the attention of the immune system's scavenger cells, which engulf them and try to digest them with acid. Professor of chemistry Jean M. Frchet, with postdoctoral fellow Niren Murthy and their ...Technique brings immune-based therapies closer to reality
...vide the number of dendritic cells needed to get a vaccine that would work." The aAPCs made by the Hopkins team created twice as many specific, targeted CTLs as using dendritic cells, and could have made even more, says Oelke, who researched dendritic cell-derived CTLs in Germany. Both aAPCs and dendriti...Patent issued to U-Iowa for mutant chicken pox virus
...has implications for the possible development of a vaccine against the new strain of chicken pox. The current chicken pox vaccine came into use in 1995, before the discovery of the mutant form and thus may offer protection only ag...Genetic blueprint for Q fever bacterium unveiled
...eal targets for improved diagnostics and potential vaccine candidates." The analysis found many genes that appear to be involved in the microbe's virulence and interactions with its human or animal host. Although the organism does not cause obvious disease in most animals, infected livestock are the primary...Q Fever microbe's genome is deciphered
...quence coupled with NIAIDs heightened emphasis on vaccine development for Q Fever and other Category B potential bioterror agents is likely to accelerate the development of better vaccines and diagnostic tests using genomic and proteomic approaches. The CDCs Thompson, co-editor of the book Q Fever: The Bi...Tips from the Journals of the American Society for Microbiology
...y present research suggesting the possibility of a vaccine that makes the recipient toxic to mosquitoes. In the study, researchers inoculated mice with DNA taken from the midgut of the mosquito Anopheles gambiae, a common carrier of malaria, and then allowed live mosquitoes to feed on the mice. After seven...Virginia Tech inventions, creations can improve lives
... retinal detachment, a treatment for hemophilia, a vaccine against brucellosis, and a therapy garment for chi... and Virginia Tech joined forces to create a "Live vaccine against Brucellosis" (6,444,445). Inventors are Mikeljon Nikolich, David L. Hoover, Richard L. Warre...DNA-based vaccine triples survival for dogs with melanoma
...malignant melanoma, treatment with a new DNA-based vaccine more than tripled their median survival from an ex... Sloan-Kettering Cancer Center where the DNA-based vaccine had undergone pre-clinical testing are reported in the April issue of the Clinical Cancer Research. ...Researchers identify new gene associated with breast cancer
...hemotherapy to induce further tumor cell death. A vaccine therapy to prevent the growth of C35-expressing tumor cells might also be a treatment approach." Breast cancer is the second-leading cause of cancer-related death in women. According to the American Cancer Society, in 2003 more than 266,000 women an...Project BioShield: Consistent financing, markets, indemnity for biodefense vaccine developers needed
... well as a degree of protection from liability for vaccine developers. Dr. Una Ryan, Ph.D., president and ch...er to achieve maximum success. "AVANT has advanced vaccine technology that is already being employed in the clinical development of a next-generation injectabl...St. Jude develops vaccine against potential pandemic influenza virus H5N1 using reverse genetics
...arch Hospital announced today the development of a vaccine against H5N1, a new lethal influenza virus that tr...neumonia in the past month. St. Jude developed the vaccine in only four weeks from the time it received the H5N1 sample from colleagues in Hong Kong. The anno...JCI Table of Contents, April 1, 2003
... Bcells. Because of the important implications for vaccine development, EricKunkel and colleagues are working to understand the mechanisms ofIgA-secreting B cell trafficking between distant mucosal sites. Havingpreviously identified a chemokine called MEC, which is expressed byepithelial cells in a variety o...Antibody therapy can increase the effectiveness of cancer vaccine, early studys
... case that combined immunotherapy consisting of a vaccine and antibodies can elicit a potent immune respons...nts, Allison's team showed that combining a cancer vaccine with an antibody able to block CTLA-4 resulted in an especially potent immune attack on tumors. On ......elanoma and two with ovarian cancer had received a vaccine produced by extracting their own cancer cells, eng...nd vaccinating the patients with those cells. This vaccine was developed by Dranoff and his colleagues at DFCI. Four other metastatic melanoma patients had rec...