Blood Test Can Identify Some Children With Strep-Related Behavioral Disorders
...p,nine children with Sydenham's chorea, which is a variant of rheumatic fevercharacterized by neurological dysfunction, and 24 healthy children. Theresearchers found that 85 percent of the children with strep-associated OCD andtics and 89 percent of youngsters with Sydenham's chorea were D8/17 positivecompar...Researchers Find Association Between Alzheimer's Gene And Mental Impairment After Cardiac Surgery
...ificant correlation between patients with the APOE variant and neurologicaldamage after surgery. "Patients with the APOE variant were more susceptible to neurologicaldamage than the other patients," Newman said. "The fact that th...Biological Clocks No Longer Found Only In The Brain
...the clock genes remained in sync. A mammalian variant of the clock gene recently was identified, and another similar gene also has been found throughout the body of mice. According to Kay, the discovery of many non-brain clocks in fruit flies could well be true for humans. "In this case it might mean ...Study Finds Gene Is Associated With Higher Risk Of One Kind of Stroke Among African-Americans
ORLANDO, Fla. -- The variant form of a gene that has been implicated inthe most... them clear cholesterol fromthe blood. The Apo-E4 variant is unable to function properly, leading to abuild-up of "bad" LDL cholesterol, which in turn can lea..."Genetic Factors Influencing Cholesterol Response To Diet"
...c trait affecting LDL response to diet isthe apoE4 variant of apoprotein E, a protein that has a number of importantfunctions in both the cardiovascular and nervous systems. ApoE4 is due to asingle DNA change in the gene for apoprotein E and has a prevalence ofapproximately one in seven in the population. ......onse to Diet." Among his topics will be the apoE4 variant ofthe apoprotein E, the most well-defined genetic trait affecting LDL response todiet. "People with apoE4 have a tendency for higher blood cholesterol levels,increased heart disease risk, and increased risk for Alzheimer's disease," hesaid. Kr...Genetic Make-Up May Determine Response To Cholesterol-Lowering Drugs
...fited from the drug. Scheuner identified a variant of the gene that was associated withunresponsivene...viduals in the study who had two copies ofthe gene variant -- about 8.5 percent of the total group -- were about twice aslikely to have progression of atherosc...Common Mutations Linked To Increased Risk Of Breast Cancer
...ed with genes like BRCA1 or BRCA2, but thisgenetic variant affects a much larger group of women. One of these geneticvariants, for example, is estimated to occur in about 44 percent of thepopulation." For the study, published in the Journal of the National CancerInstitute, Hopkins scientists compar...ACE Gene Linked To High Blood Pressure In Men But Not Women
...ver, thestudies cannot distinguish whether the ACE variant or another gene that is alsoclosely linked to ACE ... Once it is located, scientists can study the ACE variant (or a genenext to it) and determine its function. This will help them understand causesof high bloo...Gene Detected That Decreases "Bad" LDL Cholesterol In Men May Cut Heart Disease Risk By 50 Percent
...mble LDL. Individuals who carry two copies of the variant form of the genehad LDL cholesterol levels 22 perc...n. Individuals who carry a double copy of the gene variant would have a 25 percentreduced risk. "The variant of the MTP, found in six percent of the individua...New Vancomycin Structure May Point To Path For Overcoming Antibiotic Resistance
...sueof Chemistry & Biology, may explain why certain variant molecules synthesized bychemists at Eli Lilly and Co. show marked activity against vancomycin-resistantbacteria. The findings suggest that the two-molecule vancomycin assembly createdat Lilly -- referred to as a dimer -- may be configured in a so-cal...Neurogenetics Lab Scan Suggests Genetic Linkage On Chromosomes 4 And 11
...sumption, and researchers long have suspected that variant forms of GABA receptor genes may contribute to alcoholism vulnerability. To determine whether this GABA receptor gene is responsible for the chromosome 4 linkage finding, high resolution mapping will be required. Like the Collaborative Study on the...Major Risk Factor For Cervical Cancer Found
...ter the transplant. The study showed that the Arg variant conferred a strong susceptibility to SCCin these patients. Seventy five per cent of the transplant patients with SCChad p53Arg only and 25 per cent had p53Arg/Pro. "SCC in transplant patients is a very big clinical problem," said ProfessorIrene Lei...Evidence For Genetic Effects On The Behavior Of Normal Two-Week Old Babies
...ev, Israel. Many of the known human genes exist in variant or polymorphic forms thatare distributed frequentl...ent tonewborn temperament. The effect of the short variant of the serotonintransporter gene promoter, which some investigators have found to beassociated with ...Gene Variant Found That Can Help Protect Against Nicotine Addiction
Some individuals carry a gene variant that may help protect them frombecoming addicted to nicotine, according to a new study funded in part by theNational Institute on Drug Abuse, National Institutes of Health, and publishedin the June 25 issue of Nature. The study found that individual...New Alzheimer's-Associated Mutation May Provide Key To Disease Process
... A2M kept the system from workingproperly, or if a variant of apoE blocked the usual breakdown process, A-bet...n appears similar to the riskconferred by the gene variant apoE-4. However, individuals carrying bothvariants do not seem to have a further increase in their ...Gene Patterns Can Predict When--But Not Whether--Alzheimer's Will Strike
... first place. The study showed that the E-4 variant (or allele) of the APOE geneinfluenced the timing of the onset of Alzheimer's in about half of thepopulation. The study appeared in the August 19 issue of Nature Genetics. Senior author John C.S. Breitner, MD, professor and chair, MentalHygie...The Genetic Basis Of Childhood Schizophrenia
...). Childhood-onset schizophrenia (COS) is a severe variant ofschizophrenia with onset of psychotic symptoms prior to age 12. Childrenmeeting DSM-IIIR criteria for schizophrenia and showing a resistance totypical neuroleptics were analyzed for TREs using the Repeat ExpansionDetection (RED) method. An increase...Hallucinations In Schizophrenia: Genetic Findings
... and may represent the identification of anallelic variant that modifies the complex clinical presentation ofschizophrenia. Contact author: Anil K. Malhotra Long Island Jewish Medical Center New York and National Institute of Mental Health, USA tel: +1-718-470-8012 FAX: +1-718-343-1659 amalhotr@lij.edu...Subtle Changes In Brain Receptor Gene May Have Significant Consequences For Addiction
...g studies using the A118G SNP or the mostcommon mu variant in cultured cell lines. They determined that A118G had athreefold greater binding with beta-endorphin than the usual mu opioid receptor.beta-endorphin, a naturally occurring opioid peptide, plays a role in diversebiological functions, including the n...