UCSF scientist Joe Derisi named MaCarthur Fellow
...n pharmacogenetics -- the study of the way natural variations in individuals' genes affect their response to drugs. DeRisi, who designs and builds microarrays -- a technology in which gene activity is revealed on a glass slide -- to carry out his studies on infectious diseases, says he plans to use the...A test case for DNA barcodes to identify species
...ry other species, and that comparisons of sequence variations in that gene can also reveal evolutionary relationships among species. Hebert and colleagues tested the effectiveness of their genetic barcode in an extensive study of North American birds by comparing the 'species' identified from the barcode agains...Hidden diversity: DNA 'barcoding' reveals a common butterfly is actually 10 different species
...f A. fulgerator, many could be separated by slight variations in color, which then could be linked to the partic...DNA barcoding is an attempt to classify species by variations in a small signature and standardized portion of gene called cytochrome c oxidase I, common to all l...Genes expose secrets of sex on the side
... "We found lots of Y-chromosome variations that people didn't know exist," Wilder said. The new technique revealed that Y-chromosome DNA and mitochondrial DNA differ to the same degree among populations. Hammer said, "That alone wouldn't say the Y chr...Human chromosome 5 final sequence analysis released to public
...this region in hand, researchers can now study how variations in the number of deletions or repetitions influences the disease severity. For the chromosome 5 effort at JGI, Susan Lucas led the sequencing and Joel Martin the mapping and analysis efforts. Additional Stanford contributors included Jane Grimwood,...Gene expression in liver tumors and patient prognosis
...all patient population with HCC. They investigated variations in gene expression in HCC at diagnosis and compared them to patient survival over time. The researchers examined 91 HCC tissues, 60 matched non-tumor surrounding liver tissues, and 18 normal liver samples. They isolated total RNA to derive c...Images of 'tail' of protein needed for cell multiplication suggest anticancer drug targets
...he workshop that prepares NEDD8 to modify Cul1 are variations of a larger family of similar enzymes, according to the researchers. These other enzymes are part of the so-called ubiquitin pathway that puts molecular tags on proteins to signal that they should be destroyed. The ubiquitin pathway has dozens of dif...Researchers report new gene test for isolated cleft lip and palate
...med to be associated with clefting. The individual variations were then assembled into a collective profile called a "haplotype." "What we found is that a particular haplotype is over-transmitted in some families with isolated clefts, suggesting a predictive association with the birth defect, and this was true ...The impact of genetic variations on the treatment of early rheumatoid arthritis
...rchers set out to examine whether specific genetic variations could predict the response to treatment of early R...icular HLA genes in addition to particular genetic variations in the TNF gene region were found to have better responses to treatment, regardless of which drug wa...APS awards more than $140,000 to minority students of physiology
...othesize that, during HBV infection, these two PKC variations are activated and alter mitochondrial calcium sign...ne expression, and muscle contraction. Structural variations in cAMP-dependent kinases give these enzymes the flexibility to regulate multiple cellular processes...Researchers improve detection of diverse anthrax strains
...ared the results of each sequence to detect minute variations (SNPs). TGen and NAU researchers used that data to develop a typing, or identification, system for various anthrax strains. "This is the first time that a new bacterial typing system has been developed from an analysis of multiple sequenced genomes...Streptococcus infects humans by thwarting blood clotting
...said Ginsburg. Such findings also hint that subtle variations in plasminogen genes among humans could partially ..., he said, his laboratory is exploring the genetic variations in the blood-clotting system that might affect risk factors for infection. "Although this is specula...Strep disrupts blood clotting to infect humans
...o keep up." The findings also suggest that subtle variations in plasminogen genes among humans may explain why some people are more susceptible to strep infections than others. ...Columbia, Stony Brook, Guidant to develop biological pacemaker based on gene & cell therapies
...ats to fit the body's needs, as is required during variations in exercise or emotion. "The opportunity to translate this important technology from basic research into human therapy fits in with our mission at Columbia University Medical Center," said Gerald D. Fischbach, M.D., executive vice president and dea...Heartless worms hold clues to cardiac arrhythmias, sudden death
...t it." Other investigators have demonstrated that variations in HERG itself do not account for the majority of interindividual differences. Petersen and colleagues suspected that other proteins -- modulating factors -- are influencing HERG channel susceptibility to drug block. That's where the worm came in. "...Researchers report new gene test for isolated cleft lip and palate
...cine. A haplotype is the sum of several recurring variations in the usual DNA sequence of a species that are sp... they found that distinct combinations of sequence variations in and around the gene IRF6 correlated with an increased chance that a child would be born with a cl...Newly discovered protein may be key to muscular dystrophy
... defective DGC function, five others resulted from variations in a previously unidentified gene. The team cloned this gene, snf-6, and found that its sequence was similar to genes in a family of mammalian neurotransmitter transporters. Because analysis of mutants indicated defects in acetylcholine activity, the...Other highlights in the August 18 JNCI
... Ume, Sweden, and colleagues had hypothesized that variations in the MIC-1 gene, which is thought to play an important role in the inflammatory response to infection, could be associated with the risk of prostate cancer. Contact: Henrik Grnberg, Ume University, 46-90-785-1982 or 46-90-785-6888, henrik.gronber...Rare mutations can significantly increase risk factor for heart disease
...udy can be generalized to analyze the role of rare variations in candidate genes in other clinically important c...nfluenced HDL levels in a small way. However, rare variations with stronger effects are also likely to be involved. "What we wanted to know," Hobbs said, "was how...ASU researchers demonstrate new technique that improves the power of atomic force micrscopy
..."see" the chemical composition of a sample, follow variations of the sample, as well as map its topographic structure. The advance could have significant implications for drug development by allowing scientists to monitor the effects of potential drugs on an ever-smaller scale, according to Stuart Lindsay, dir...