Researchers find protein mechanism for potential atherosclerosis development
...a protein that helps regulate the proliferation of vascular cells increases the chance of developing atheroscl...Neuroscience, discovered that inactivating LRP1 in vascular smooth muscle cells caused the overexpression of PDGF receptor and abnormal PDGF receptor signaling ...Location of ulcerations in diabetic patients may be explained by blood flow
...by the plantar surface of the foot to improve skin vascular compensatory mechanisms....A cholesterol-controlling drug could strike a blow against insulin resistance
...his effect appears to be related to stimulation of vascular NO availability (as evidenced by the results in eNOS-/- mice). These data suggest that simvastatin may help to combat the epidemic of insulin resistance and hypertension in humans....Arthritis drug suppresses cancer development by stopping action of key protein
... growth. One of those genes triggers production of vascular endothelial growth factor (VEGF), the predominant angiogenic factor that leads blood vessels to grow to feed tumors. The findings were published in the Proceedings for the 2003 Annual Meeting of the American Association for Cancer Research. "Our r...JCI Table of Contents, April 1, 2003
...on of the neointima that ultimatelyimpinges on the vascular lumen. RAGE, the receptor for advanced glycationend products, is upregulated at sites of vascular pathology, and itsblockage is beneficial in mouse atherosclerosis models. Yoshifumi Naka andcolleagu...VEGF gene transfer fails to help peripheral arterial disease patients
...ed cold virus (adenovirus) containing the gene for vascular endothelial growth factor (VEGF). The injections were targeted to the leg with the worst symptoms. RAVE was designed to use the adenoviral vector to express the VEGF gene at the disease site, increasing the ability to spur growth of new blood vessel...Phase III study results with Raptiva in the treatment of psoriasis presented at Annual AAD meeting
...biotherapeutic agents, CAB2 and MLN01, for certain vascular inflammation indications (preclinical); and with Onyx Pharmaceuticals, Inc. on its ONYX-015 product for various cancers (current activities suspended, pending partnership discussions). Earlier-stage development programs include compounds to treat can...Results from open-label Raptiva study suggest continued benefit with long-term treatment
...biotherapeutic agents, CAB2 and MLN01, for certain vascular inflammation indications (preclinical); and with Onyx Pharmaceuticals, Inc. on its ONYX-015 product for various cancers (current activities suspended, pending partnership discussions). Earlier-stage development programs include compounds to treat can...New study clarifies connection of brain and heart failure
...t peripheral nerve fibers connecting the heart and vascular tree to the central nervous system are altered in ...ences of RAAS, e.g., vasoconstriction, cardiac and vascular remodeling, while increasing the ability of these agents to penetrate brain regions whose intrinsic ...UCSD biologists discover key to blocking inflammation
...t those locations. "When you have a cut, the local vascular structure surrounding the wound is disrupted and there's no longer a normal supply of oxygen being delivered," says Randall S. Johnson, an associate professor of biology, who headed the study. "White blood cells (leukocytes) constitute the first line...The elusive preeclampsia factor discovered?
...egrity of the mother's blood vessels. Acompromised vascular system could explain many of the symptoms ofpreeclampsia. In the second article, Susan Quaggin and colleagues of the Samuel LunenfeldResearch Institute in Toronto, report that reducing the levels of oneparticular angiogenic factor (called VEGF-A) in...JCI table of contents, March 3, 2003
...oinflammatory response to evenmodest elevations of vascular pressure. This involves expression of theleukocyte adhesion receptor P-selectin on endothelial cells, which increasesleukocyte rolling on the vessel surface. Interested in the underlyingmechanisms, Jahar Bhattacharya and colleagues applied real-time,...Enzyme controls 'good cholesterol'
...y heart disease, Chan said. "It also protects the vascular wall," he said. "It may also slow down the oxidati...ng working against inflammation and protecting the vascular wall, that would have to be balanced against the interruption of cholesterol transport to the liver....Researcher explores tumors' survival strategy
... studies these cells that line blood vessels, this vascular biologist at the Medical College of Georgia focuse...es and matrix components to form a new, functional vascular bed that is believed to accelerate wound healing. The fact that many tumors also activate angiogenes...Endothelial progenitor cells could serve as biological marker for cardiovascular disease
...vessels and that a lack of these cells can lead to vascular dysfunction and the progression of cardiovascular ...elation between the brachial artery measurement of vascular function and the number of circulating endothelial progenitor cells. The correlation between the br...New hope for preventing major problems of the retina
...dopamine on the pathways coupling sensory input to vascular response. Dopaminergic functions in the eye are co... blood flow. It is known from several tissues that vascular effects of dopamine are not only mediated via specific dopamine receptors but also by influencing ot...Gene that helps blood vessels form linked to complex birth defect
...rom across the globe reports that abnormalities in vascular endothelial growth factor, or VEGF, is a cause of ...e a wide range of heart defects, many of which are vascular in nature, as well as problems with the thymus and parathyroid gland, craniofacial abnormalities and...Computer model offers noninvasive evaluation for abdominal aortic aneurysm rupture risk
...rnational symposium sponsored by the department of vascular surgery at the Karolinska Institute and Hospital. The symposium is designed for vascular surgeons, radiologists, researchers and other professionals interested in AAA treatment. Using measu......ight into the molecular cues that direct blood and vascular development -- a crucial event in both normal and ...ssant Flk1 encodes a cell surface receptor for the vascular endothelial growth factor (VEGF), a crucial factor in angiogenesis. Transgenic mice lacking Flk1 fai......ced by a chemical stimulus transported to buds via vascular tissue, and that its efficacy was dose-dependent....