Tag: "version" at biology news

Researchers determine genetic cause of Timothy syndrome

...ism. Cell culture studies of the mutated version of the channel revealed that it did not react properly to block calcium flow at the appropriate time. This abnormality could explain the lethal cardiac arrhythmias in Timothy syndrome patients, said Keating. Further genetic analyses of the ...

UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies

...ings of the National Academy of Science. The print version of the research paper will appear in the Sept. 28 issue of the journal. Human immunodeficiency virus, commonly known as HIV, is known to cause AIDS. The virus attacks the body's immune system, making the body vulnerable to infections and certain canc...

Genes expose secrets of sex on the side

...turally accepted fashion, Wilder said. "The modern version that we generally don't find offensive is that men tend to remarry and have more children much more often than women do." The team's research also overturns the long-accepted idea that, on average, women's genes traveled farther from their birt...

Genetic analysis rewrites salamander's evolutionary history

...e larval stage, emerging from the egg as a smaller version of an adult. The new family tree shows, however, that some terrestrial salamanders regained their larval stage after moving back to the water. This may have happened in three separate lineages of Plethodontids, which is surprising for a seemingly com...

Molecule awakens and maintains neural connections

... When the researchers blocked the activity of the version of the Dasm1 gene found in rats, they found dendrite arborization to be drastically reduced in cultured brain cells. The researchers also studied the effects of Dasm1 on the maturation of neuronal connections, or synapses. Newly formed, immature syn...

Recent evolution at a single gene may have brought down heart disease risk in some human groups

... of arteries. Individuals with the low-expression version of the gene are slightly more prone to atherosclerosis, the narrowing of the arteries associated with the accumulation of plaque in the arterial walls. The new research shows that the high-expression variant increased rapidly in frequency in the anci...

Disease diagnosis, drug development focus of UH prof's biochip research

... attend the conference in Australia. This virtual version of the conference also will provide Internet participants an opportunity to post questions and discussion items. Nanoscience is strongly multidisciplinary, and the conference will reflect this diversity with contributions from physics, chemistry, ...

Scientists discover proteins involved in spread of HIV-1 infection

... Previously, scientists determined that the yeast version of TSG101, called Vps23p, binds to two other prote...s colleagues report that they have found the human version of Vps37p. "Our paper describes the identification of the human VPS37 proteins. This is a necessary ...

Genetic clues found for common congenital brain disorder

...t of the mice that had one normal and one abnormal version of both ZIC1 and ZIC4 had abnormalities in the cerebellum that were very similar to the brains of patients with Dandy-Walker. They also lacked coordination and were unable to right themselves if they fell over. Although the authors conclude that "h...

Heartless worms hold clues to cardiac arrhythmias, sudden death

...vantage of a worm line with a mutation in the worm version of HERG. The mutation, unc-103, causes profound neuromuscular defects, including a pharyngeal pumping defect that Petersen noticed as she learned to work with the worms. "I remember the first time I saw it (the pumping defect)," she said. "It looked...

Using statistics to decipher secrets of natural mutation

... neutral mutation, Hwang and Green developed a new version of a powerful statistical technique that they call "Bayesian Markov chain Monte Carlo sequence analysis." Basically, the technique enables them to feed in sequence information from genomes of different organisms and discern patterns that can distingu...

Nerve cells 'guided' to repair spinal damage: Technique

...rds. The technique, outlined in the July 6 online version of Biomaterials, involves imbedding a series of fibrous rods into a gel substance and then dissolving the rods, leaving a series of longitudinal channels. These channels are then injected with peptides, molecules that stimulate cell adhesion and migr...

Jefferson scientists find gene expression pattern may predict behavior of leukemia

...porting in both the online and the August 10 print version of the Proceedings of the National Academy of Sciences, the researchers taking advantage of a microarray chip Dr. Croce and his colleagues designed that carries all the known human miRNA genes compared the expression of miRNA genes in human CLL sam...

Transcriptional gene silencing in nucleus shown by UCSD/VA medical researchers

...ious gene-silencing techniques is that the nuclear version may have the potential to last considerably longer than current methods that act in the cytoplasm, the cellular area outside the nucleus. The new technique, and older gene-silencing methods that have given rise in recent years to a multi-million dol...

Social benefits of wound healing may not make any difference in animals with multiple partners

...ese findings are currently published in the online version of the journal Brain, Behavior and Immunity. Social contact benefited the monogamous mice corticosterone levels were lower, and wounds also healed faster. But separated pairs lost this benefit, even if the mice in a separated pair could still se...

New glycan arrays discover autoimmunogenic activities of SARS-CoV: concern over monkey vaccine

...f the media are encouraged to obtain an electronic version and to interview members of the research team. To do so, please contact Mayer Resnick at APS 301-634-7209, cell 301-332-4402 or mresnick@the-aps.org . The American Physiological Society was founded in 1887 to foster basic and applied bioscience. The...

Firefly compound lights up 'protein dance' in living animals

...t luciferase. "We were ideally looking for a split version of luciferase that had zero activity when separated but had very high light output when the partner proteins interacted," he explains. Researchers led by Kathryn E. Luker, Ph.D., a postdoctoral fellow in Piwnica-Worms' lab, first divided luciferase i...

Insecticide resistance: A constraint on evolutionary change

...base-pair alteration, G119S, within the mosquito's version of the AchE1 gene conferred high levels of resista.... First, the researchers determined that the G119S version of the Ae. aegypti AchE1 protein was indeed resistant to insecticide action in the test tube, sugg...

Good bacteria trigger proteins to protect the gut

... may be that such patients could be treated with a version of the bacterial cell surface products that would mimic the presence of commensal bacteria and maintain TLR activity," said Medzhitov. Additionally, the findings may also influence the treatment of inflammatory bowel disease. "We know that ba...

Scientists discover new intricacies in how ulcer bugs stick to stomach

...ility--it no longer could bind to anything but the version of Lewis b associated with blood type O. "You might call these strains the specialists, and other versions of H. pylori the generalists," Berg says. "These specialist strains are related to Spanish strains of H. pylori, so these adaptations m...

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