Clinical study results published in NEJM show promising data on Antegren (natalizumab)
... the treatment period in the placebo group (n= 71) versus 0.7 and 1.1 in the 3 mg/kg (n= 68) and 6 mg/kg groups (n=74), respectively. There was a reduction of approximately 50% in the number of patients experiencing a relapse in the natalizumab groups compared to placebo a tertiary endpoint of the study....Antegren (natalizumab) clinical study results published in New England Journal of Medicine
...umab treated patients in clinical remission (n=29) versus 27% in the placebo group (n=17). A significant di...ponse of 71% in the dual 3 mg/kg dose group (n=47) versus 38% in the placebo group (n=24). Secondary outcomes included improvements in quality of life as dete...International functional genomics study looks for genes that cause drug tolerance and dependence
...will determine the gene expression of regular mice versus genetically altered mice who do not become toleran...hich genes are turned on and turned off, or normal versus abnormal, to determine which genes are expressed in a particular disease or condition. Proteomics ta...JCI table of contents, December 15, 2002
...a anaphylatoxin is a major regulator of activating versus inhibitoryFc[gamma]Rs in immune complex induced lung disease CONTACT: J. Engelbert Gessner Hannover Medical School Dept. of Clinical Immunology Carl-Neuberg Str. 1 30625 Hannover, GERMANY Phone: 49-511-532-3621/3919 Fax: 49-511-532-5648 E-mail: Ge...New study pursues the impact of pregnancy on drug efficacy
...oxic drugs to see if blood levels vary in pregnant versus non-pregnant women and primates....Three inferior prefrontal regions of the brain found receptive to somatosensory stimuli
...ding to somatosensory stimulation/passive fixation versus attend vision/ignore somatosensory produced a significant activation of the right IFG pars triangularis Conclusions The data from the two studies provide evidence for at least two discrete ventral frontal brain regions that respond to somatosensor...INEEL researchers discover that concrete degrades nerve agent and can predict rate of decay
...spectra (a bar graph that plots the number of ions versus their mass) that researchers then use to identify the chemicals. One advantage of INEEL's IT-SIMS is that researchers trap secondary ions and then use precisely chosen electromagnetic frequencies-called tickle voltages-to fragment the ions into stil...Algorithm predicts interactions between proteins whose structures are unsolved
...h is based on understanding how a drug affects you versus how it affects me." He noted: "With this paper, we are moving toward an understanding of how the whole system works, what's known as systems biology, which is the key revolution in the post-genomic era," he explained. According to Skolnick, compl...Fosrenol (TM) reduces damaging high levels of phosphate in end-stage kidney disease patients
...carbonate than calcium carbonate (5.36mg/dL 1.426 versus 5.33 mg/dL 1.479), with similar treatment-related side effects, after six months of therapy. The study, conducted by Alastair J. Hutchison, F.R.C.P., M.D., consultant nephrologist and clinical director of the Renal Unit at The Royal Infirmary in Ma...New findings reconfirm toxicity of Pfiesteria cultures
...rown with the test strain of Pfiesteria shumwayae, versus tilapia grown with a known toxic strain. Some control fish were grown with a known nontoxic Pfiesteria strain, while others were maintained without any Pfiesteria. Once the strain was rapidly killing fish, it was re-isolated from the fish cultures an...Researchers identify a gene essential for the natural killer cell response against cancer
...gulation of perforin gene expression in the innate versus the adaptive immune system provides a selective target for future therapeutic interventions," explained H. Daniel Lacorazza, Ph.D., the study's first author....COX-2 inhibitors may delay onset of breast cancer
...0 percent of the control mice at 32.3 weeks of age versus 39.6 weeks of age in the celecoxib-treated mice. The incidence of breast tumors was lower at all subsequent ages for the celecoxib-treated mice relative to control mice. This protective effect was achieved at drug levels that can be safely administ...Tiny, magnetic spheres may help overcome gene therapy hurdle
...ker protein in the magnetized areas of the culture versus the others. "If you think about it in terms of making doses, it might take about six months to make a single-patient dose of this vector currently," Byrne said. "If this works, I'd say we could do it in four to six weeks or even less." The microsphe...American Society for Microbiology Journals tipsheet: September 2002
...erosclerotic lesion formation in the infected mice versus the control mice. "The present study further supports the hypothesis that C. pneumoniae is not an independent risk factor but acts in concert with hyperlipidemia to exacerbate atherosclerotic lesion formation," say the researchers. (E. Blessing, L.A...Early evaluation critical for kidney disease patients' survival
... common among black men than white men (45 percent versus 25 percent), uninsured patients than insured patients (57 percent versus 29 percent) and patients with severe co-existing disease than those with mild or no co-existing dise...After massive experiment, results favor wildlife corridors
...tch's) droppings in the connected receiver patches versus the unconnected patches," Levey said. The findings may go well beyond pollination and seed dispersal. When plants have more pollen, they produce more fruit, attracting more birds, which distribute more seeds, which attract more birds and seed-eating...Personal body part grown in a dish
..."It's analogous to the penis of a 60-year-old man, versus that of a 30-year-old," says Atala. Details of the work will be published in the October issue of The Journal of Urology. The team is now trying to improve the quality of the tissue, to make it comparable with that of a young animal. His lab is also...Male birds' ability to learn song affects female mating response
...lity -- how much of the wild-bird song they copied versus how much they invented, a practice common among song sparrows. Those birds who did invent more song elements also tended not to copy well those elements they did copy. -- how close the males had come to actually matching just the wild-bird song eleme...Proposed remedy for forest fires puts economic interests first
...ralism in the Forest: National versus State Natural Resource Policy" (Georgetown University Press, 2002.) In it, he takes a look at the regulatory differences between federal and state forest agencies. He doe...... or flee by judging the relative number of friends versus foes; in foraging, choosing a larger alternative c...d was smaller (e.g., making a comparison between 3 versus 2 dots was more difficult than a comparison between 5 versus 2 dots). Neurons became less precisely...