Tumor Suppressor Gene Located In Liver Cancer Cells
...wide, particularly because of its association with viral hepatitis," said Jirtle, a professor of radiation oncology and cancer center member. The lack of effective treatments also makes it a particularly deadly disease, he said. "As a consequence, knowing something about liver tumor formation or having a ...Virginia Tech Researchers Receive Patent For Rapid Virus Detection Technology
...release their cellular contentsas a consequence of viral infection. Thus, the release of compoundsthat are normally only found within cells is indicative of thepossible presence of a virus," says Hagedorn. The test detects a specific compound(an enzyme) released from cells in the test medium -- "acellular...Northwestern Scientists Discover How Herpes Simplex Virus Infects Cells
...periodic reactivation of thevirus. Consequences of viral replication include cold sores and feverblisters, similar lesions on the genitalia, corneal destruction,encephalitis and severe disease of newborns. The virus can bind to manytypes of human cells but is capable of penetrating only certain cell types....Disease Resistance Mechanism Identified in Plants
...nt's ability to fend off an attacking bacterial or viral disease is somehow linked to the complementary activity of genes in both the plant and the pathogen - the disease-causing agent. Previous genetic research has suggested that an avirulence gene in the pathogen triggers a resistance response in the in...Mechanism For Disease Resistance Identified In Plants
...nt's ability to fend off an attacking bacterial or viral disease is somehow linked to the complementary activity of genes in both the plant and the pathogen - the disease-causing agent. Previous genetic research has suggested that an avirulence gene in the pathogen triggers a resistance response in the in...A Sensor, A Switch, A Zipper: Protein Engineers Design Potential Tool
...as gene transcription, muscle contraction, viral attack, and cell division. Please acknowledge partial funding for this work from the National Institute of General Medical Sciences (NIGMS), a component of the National Institutes of Health dedicated to the support o...Scientists Determine 3-D Crystal Structure Of Cancer-Causing Protein
...e. Scientists have long known that, in the viral form of the Src protein, thephosphotyrosine is missing, resulting in the transformation of normal cellsinto cancerous ones. The work by the Hughes-Rockefeller team confirms earliermodels that showed the change in the protein's shape that enables it t...High Levels of Vitamin C Prove Toxic to HIV
...ither had no effect or caused a slight increase in viral replication. But exposure to high vitamin C levels more than 20 times greater than normal decreased replication of the AIDS virus and was generally more toxic to HIV-infected cells than to the uninfected cells. Such high blood levels of vitamin C ...Herpes-Based Gene Therapy Is Key To Promising Liver Tumor Vaccine
...ople and animals. It takes the herpes simplex viral amplicon vectors onlyabout 20 minutes to slip genes into cells, Dr. Federoff says,much faster than other gene delivery methods like retroviruses.That's fast enough for cells to be modified and put back into apatient during the same surgical procedure...Herpes-Based Gene Therapy Is Key To Promising Liver Tumor Vaccine
...st people and animals. It takes the herpes simplex viral amplicon vectors only about 20 minutes to slip genes into cells, Dr. Federoff says, much faster than other gene delivery methods like retroviruses. That's fast enough for cells to be modified and put back into a patient during the same surgical proce......a protein secreted by cells that "interferes with" viral infection and other challenges. Earlier studies in Japan showed that interferon-resistant HCV strains have a specific RNA sequence within a region of the virus called NS5A. The UW researchers followed up on this research, and tested the abili...New Vaccine Blocks Viral Entry In Cattle, May Have Implications For Human Vaccines
...the implications his findings have for controlling viral diseases in humans. "I think our research here wil...understanding of the role mucous membranes play in viral infections. "When you think about it, most viruses enter animals and people through mucous membran...Genetic Trickery Offers New Way to Target HIV
...that the enzyme reverse transcriptase can copy the viral genetic code. Initiating the copying process atprecisely the right spot is the primer's critical task. Rosenblatt's team genetically engineered a new primer, amutant tRNA that docks at a different site on the HIV template,causing reverse transcr...Stopping "Cellular Suicide" Could Boost Production In Biotech Labs
...red by changesin acell's environment. "It may be a viral infection, the loss of akey nutrient,radiation or a chemical toxin--all at sub-lethal levels,"Betenbaugh explains."These would not kill the cell by themselves. Nevertheless, thecell turns onthis physiological chain of events that causes it toself-des...Jefferson Scientists Discover Mechanism Of Viral Link To Disease Commonly Associated With Asbestos
...toma family ( pRb , pRb2/p130 , and p107 ). A viral protein called SV40 T-ag (T-antigen) binds to and inactivates the tumor-halting proteins, causing them to lose their natural ability to regulate cell growth and prevent cancer. The discovery underscores the important role that Rb family...Common Childhood Virus Poses Threat To Adults, Research Shows
...ts for Respiratory Sincytial Virus (RSV),a form of viral pneumonia, they sometimes misdiagnose it as bacterial pneumonia,which requires different treatment. “Antibiotics for bacterial pneumonia don’t work against RSV,so if we think somebody has pneumonia and they really have RSV, we don’the...Molecular Piracy Turns Protein Into Traitor
...mulate the normal response. Instead, the resulting viral chemokine, vMIP-II, acts as an antagonist blocking the normal action of the receptor. Even more surprisingly, vMIP-II is able to block two distinct types of chemokine receptors, so called CC and CXC receptors. This is the first known molecule able t...Mutant Gene Not Sole Explanation For Hiv Non-Progression
...genetic and other host factors, and viral factors contribute to the clinical profiles ... measured, including CD4+ T cell counts and viral load in the bloodstream and lymph nodes. "Although an ...Pharmaceuticals Manufactured In Insect Larvae
...for other purposes, like manufacturing inexpensive viral insecticides as alternatives to pesticides. Wood and Hughes said that with more than 30,000 chemical pesticide registrations being canceled in the past eight years, there is a need to develop natural and genetic baculoviruses. The researchers believ......ts a cellular chemokine receptor, ratherthan HIV-1 viral components. "This approach may provide a new paradigm for thetreatment of HIV-1 infection, that is, to protect cells from HIV-1 infection,rather than to inhibit HIV-1 replication," Chen said. "As long as this approachcan protect sufficient amounts of...