JCI Table of Contents, 15 July 2004
...ation Impairs T Cell Induction TITLE: Hepatitis C virus mutation affects proteasomal epitope processing AUTHOR CONTACT: Barbara Rehermann NIDDK, NIH, 10 Center Drive, Bethesda, MD 20892, USA. Phone: 301-402-7144; Fax: 301-402-0491; E-mail: Rehermann@nih.gov View the PDF of this article at: https://...New database to help develop AIDS drugs
...eveloping drug treatments for AIDS or studying the virus that causes the disease have a new resource---an o...ural data for proteins involved in making HIV, the virus that causes AIDS, as well as molecules that inhibit these activities. Until now, much of this inform...Report outlines steps needed to lessen smallpox threat
...deadly spread of smallpox following release of the virus by terrorists may rest with the establishment of a.... Second, the impact of intentional release of the virus would "probably provoke a global health crisis." The report states that "the lethality of the diseas...Gene therapy alternative to calcium channel blockers
...conductivity, called G-protein Gem, by injecting a virus carrying the gene that codes for the protein into the animals' heart muscles. Increased levels of Gem decreased calcium current densities the chemical action of calcium channel blockers by 30 percent to 90 percent, when compared to a control grou...Call for greater involvement of developing world scientists in fight against AIDS
...a long way from reality. Drugs that help fight the virus and alleviate the disease symptoms are available, but are expensive and unavailable to many sufferers living in the world's developing countries. In addition, many countries are still failing to tackle the social issues that lead to the further sprea...Study suggests first molecular target to halt spread of HPV
...NAs used for production of E6 and E7 proteins, the virus would no longer be able to trigger cellular proliferation. "There are some unique characteristics of E6 and E7 which make them good targets, most importantly, their critical role in overcoming cell growth control pathways," said Clawson, who is also...Asian bird flu became highly pathogenic through continued circulation and gene swapping
(MEMPHIS, TENN.--July 8, 2004) An avian influenza virus that has caused three major outbreaks among poultr...s collected since 1997 traces the evolution of the virus into a dangerous pathogen through a series of reassortment events. Results of the study indicate tha...Mosquito researchers track dengue fever in Sonora, Mexico
... species in Sonora and of the four types of dengue virus and its close relative, West Nile virus. "The eco...m patients to identify which strains of the dengue virus caused the infections. Sonora once had only two types of the dengue virus but now all four are foun...Study supports association between HPV infection and head and neck cancer
...vical cancer. Some studies have suggested that the virus may also play a role in the development of HNSCCs, and HPV DNA has been detected in the tumors of 10% to 20% of HNSCC patients. In addition, active HPV DNA can be found in the tumors of HNSCC patients who do not drink or smoke--factors that have been...UNC research accelerates discovery of novel gene function
...e developed allows us to take candidate genes from virus to bacteria to cell to animal, quickly and efficiently." The technique system may have clinical applications, including drug design, Kafri added."We could easily modify the library to find peptides or small molecules with potential to act as inhibito...Combination of gene therapy and gene silencing prevents neurodegenerative disease
...d that their gene therapy vector, adeno-associated virus 1, specifically targeted Purkinje cells, which are very important for gait and coordination. "Choosing the right vector for the right cells could help us limit gene expression to those cells where altering expression will have a beneficial effect," D...As humans alter land, infectious diseases follow
...mple cited in the report is the emergence of nipah virus in Malaysia and Singapore in 1999 when El Nino-fue... bats from their forest habitat to farms where the virus was transmitted to pigs and humans. The report makes a series of recommendations to address the iss...Measuring artificial viruses to improve disease detection
...olution. By knowing exactly how much of the "fake" virus is present in a patient sample, a lab can better detect any additional signal caused by real virus molecules. Traditional methods for measuring concentrations don't work well with the new product sin...Herpes tool allows researchers to customize Alzheimer's vaccine
...genital lesions. Federoff has pioneered use of the virus as a potential tool to fight Parkinson's disease, ...Alzheimer's disease, stroke, cancer, and AIDS. The virus is adept at infecting a variety of cells, and scientists are using that ability to introduce into ce...New milestones on the path to conquering HIV drug resistance (AIDS)
...ers to why it is relatively difficult for the AIDS virus to develop resistance to the drug, tenofovir, or t...rs. RT is the enzyme or molecular machine the AIDS virus uses to replicate its genetic material. The two life-saving drugs approach the problem of drug resis...RSV can increase the risk of asthma, UT Southwestern researchers find
... mice, suggests that a medication neutralizing the virus could decrease children's chances of developing as...d the study's senior author. "RSV is a very common virus and one of the most frequent respiratory illnesses. Most babies will get over the infection, but som...Kaposi's sarcoma virus 'reprograms' blood vessel cells into lymphatic cells
...ood-vessel-lining cells that are infected with the virus that causes the skin tumor Kaposi's sarcoma (KS) a...velop into lymphatic-lining cells. Because the KS virus can infect blood vessel lining, the research team decided to investigate whether it might similarly ...'Search and destroy' protein turns tables on HIV
... ST. PAUL -- A human protein that mutates the AIDS virus (HIV) and holds potential for keeping the disease ...t Biology. In an individual infected with HIV, the virus uses the human cellular machinery to assemble new viral particles. But sometimes those particles con...Researcher issues caution on live virus vaccines
...ork Medical College microbiologist warns that live virus vaccines to prevent infectious diseases like West Nile virus and yellow fever could have dire consequences. Should one of the vaccine flaviviruses recombine with......ave unlocked part of the mystery of how a harmless virus known as GBV-C slows the progression of HIV and pr...V-C, a benign cousin of the hepatitis C virus. The virus infects almost all HIV patients at some point in their illness, but seems to cause no harm by itself...