National Cancer Gene Therapy Foundation gives $4.0 million in research grants
... a genetic element expressed in ECPs and created a virus that uses this element to target gene expression d...eveloping virotherapy for prostate cancer, using a virus called Sindbis (SB). ROBERT VONDERHEIDE, MD, PhD, Abramson Cancer Center, University of Pennsylva...Gene therapy reduces drinking in rats with genetic predisposition to 'alcoholism'
...ts delivered the gene by first inserting it into a virus that had been rendered harmless. They then injected the virus directly into the rats' nucleus accumbens, the brain's pleasure center. The idea behind this type of...Transplant rejection averted by simple light exposure in Stanford animal study
...-cells to come to a particular site to fight off a virus or bacteria. But in transplants, they do patients a great disservice, alerting T-cells to attack the patient's own tissues, researchers found. The researchers were able to effectively eliminate the Langerhans cells in transplanted mice by exposing th...Jay Levy honored with 2004 Abbott Laboratories Award in Clinical and Diagnostic Immunology
...ndependent discovery of the human immunodeficiency virus (HIV) and his explication of cellular immune respo...ous species, not the animal species from which the virus was isolated. This finding confirmed the germ line transmission of viruses and led to a greater appr...Govindarajan Dhanasekaran wins 2004 Sarber Award from American Society for Microbiology
...n turkeys and chickens. No vaccine against the APV virus currently exists, and the virus has had devastating economic effects on the U.S. poultry industry. He is now at work on recovering i...Experimental smallpox DNA vaccine protects primates from lethal monkeypox
...s concern that undisclosed reference stocks of the virus may exist, and its potential as a biological weapo...accine on four genes from vaccinia virus--the same virus used in Dryvax, the licensed smallpox vaccine. Because Dryvax contains live virus, it carries a hig...Newly discovered gene controls levels of 'bad' cholesterol in mice
...Pcsk9 does, Maxwell inserted the Pcsk9 gene into a virus that targets the liver and injected the virus into normal mice, where it made Pcsk9 protein inside liver cells. With abnormally high levels of Pcs...Researchers discover cold virus can 'hit and hide'
...earchers has discovered that respiratory syncytial virus (RSV), a common cold virus causing bronchiolitis in children, can act as a 'hit and hide' virus. It was thought that the virus ...Researchers report definitive evidence that HIV-AIDS is not from oral polio vaccine
...IV comes from a chimpanzee simian immunodeficiency virus (SIV) that infected humans, when and how SIV jumpe.... The new SIV is not the one from which HIV-1, the virus responsible for the human AIDS pandemic, originated. The research shows that the new SIV resides on ...Sick Kids researchers look at viral triggers for multiple sclerosis in children
...atric multiple sclerosis (MS) and the Epstein-Barr virus (EBV), indicating that exposure to the virus at a certain time in childhood may be an important environmental trigger for the development of MS. ...Tips from the Journals of the American Society for Microbiology
...hopoxvirus, family Poxviridae, including VACV (the virus used in the current smallpox vaccine), monkeypox virus (MPOV), and variola virus (the virus that causes smallpox), are highly similar in the majority of th...UNC researchers identify virus gene involved in tumor cell growth, spread
CHAPEL HILL -- In studying a virus that causes the skin cancer Kaposi's sarcoma, University of North Carolina at Chapel Hill scientists have identified a viral gene that switches on cellular genes involved in promoting tumor cell growth and metastasis throughout the body. The K1 gene ...A new hypothesis about autoimmunity. Is it possible to be too clean?
...hat Type 1 diabetes is often initiated by a common virus that infects cells in the pancreas. During the viral infection, the body makes an adaptive immune response, and killer T cells selectively target and eliminate other cells in the body that are infected with the virus. However, the T cells themselves...Fish no exception to trend in marine-organism disease
...are suffering from large tumors caused by a herpes virus that has spread over the last two decades. Marine mammals have a variety of viral and bacterial ailments, some of which also seem linked to human activities. Mollusks, such as commercially farmed oysters, could be experiencing increasing stresses......rge numbers of seals succumbed to canine distemper virus in 2000, presumably contracted from domestic dogs. Such human incursions cause even more damage by exacerbating the effects of naturally occurring parasitic and pathogenic diseases. While all indicators point to a real increase in disease in marine o...St. Jude researchers create image of enzyme that orchestrates natural genetic engineering
New insight into the structure of a virus enzyme that orchestrates a natural type of genetic...replicated to produce two new pieces of DNA. T4, a virus that infects bacteria, uses UvsW during a process called recombinant-dependent replication (RDR). RD...Reporters from Science Magazine to receive ASM Public Communications Award
...ise, and it provides an in-depth look at where the virus originated and how it developed in humans. Now ... food in an attempt to determine the source of the virus and how it was transmitted to humans. Normile has been the acting Tokyo Bureau Chief for Scien...Warning to preserve 'unique' red squirrel from extinction
...-competes reds for food and passes on a deadly pox virus which can kill reds within two weeks. Although Cumbria is benefiting from a red squirrel conservation programme, researchers say this may not be enough, and argue that these animals should be included in a captive breeding programme as an additional...Gene with key role in replicating pox viruses also halts inflammation
...mallpox, have determined that a gene necessary for virus replication also has a key role in turning off inf...e at Urbana-Champaign. "If we can find out how the virus evades immune responses and learn more about the signals the virus sees as necessary for replicating...The deadly virus HIV can mutate to prevent display of its component... viral protein. Cells infected with this mutant virus are not detected by the immune system, so the virus can replicate and increase in number. This was i...