Jefferson scientists use gene therapy to restore function of damaged heart cells in lab
...in Philadelphia, and his colleagues at Duke used a virus to carry a gene into the heart cells of individual...trong the individual heart cells were beating. The virus used in this study is a version of the common cold virus that has been rendered non-infectious and s...Genetic trick adapted from viruses makes gene therapy vectors more versatile
... first be changed back into DNA. A retrovirus is a virus whose genetic material is RNA instead of DNA. The St. Jude team used these multicistronic retroviral vectors (vectors carrying several different genes) to deliver the 2A peptide-linked CD3 gene cassettes into hematopoietic stem cells from mice that l...JCI table of contents, 2 April 2004
...lems. Using a novel recombinant adeno-associated virus vector they deliver a modified FVII transgene that...tory CD8+ T cell population in chronic hepatitis C virus infection AUTHOR CONTACT: Vincenzo Barnaba Universita degli Studi di Roma, Rome, Italy. Phone: 39-06...Gene-rich human Chromosome 19 sequence completed
...cleic acid recognition, reverse transcription, and virus assembly. Drug development efforts seek to disrupt these zinc finger structures to prevent viruses from functioning. Chromosome 19, however, was not without its challenges, Myers added. The sequence was harder to work through than expected. It was hi...Damania of UNC receives Elion cancer research award
...n malignancies." Damania tudies an oncogene of the virus named K1. Her research aims to decipher how this gene can transform cells to become malignancies. Damania has already performed groundbreaking work related to KSHV and has published more than 20 journal articles on the subject. Damania earned her do...Study: Mimicking viruses may provide new way to defeat them
...a harmless molecule that uses the same machinery a virus needs to grow may be a potent way to shut down the virus before it infects other cells or becomes resistant to drugs. The results are published in the March ...Study points to possible cause of asthma exacerbations
...eam specifically showed that respiratory syncytial virus (RSV) infection increases the number of a type of ...hma and asthma exacerbations. They found that this virus increased both the amount and the surface expression of the receptors for endotoxin on cells lining ...Ribozyme package effective against hepatitis B virus
...s for and destroys up to 80 percent of hepatitis B virus in the livers of mice. "This marks one of the few...in the journal's April print edition. Hepatitis B virus (HBV) attacks the liver and can cause lifelong infection, liver cancer and, eventually, death. Altho...Study offers new model for breast cancer
...y genetically engineering the stromal cells with a virus that over-produces two proteins implicated in breast cancer, many of these mice formed pre-cancerous human growths in the breast tissue grafts. "This means that we should now be able to use these mice to study the early stages of human breast cancer ...AIDS drug helps to keep HBV at bay during chemotherapy for breast cancer
...o help prevent the reactivation of the hepatitis B virus in women who are being treated with chemotherapy f...presses the immune system and therefore allows the virus to replicate. Once chemotherapy stops, the immune system recovers and attempts to clear the virus a...Primate viruses transmitted to people through bushmeat
...report the presence of antibodies for simian foamy virus (SFV) in 1 percent of the people tested. People in...separate species of monkey and ape. "Simian foamy virus should be considered a novel retrovirus of humans. Researchers have documented animal to human trans...Heart and lung transplantation clinical trial results to be announced at ISHLT meeting
... Topics to be presented include: SARS, West Nile virus and HIV Infectious disease and how they affect thoracic transplantation Latest data from United Network for Organ Sharing (UNOS) and international organ procurement organizations discussing disparities in organ allocation and use Current perspecti...JCI table of contents, 15 March 2004
...onse to HIV infection is important for controlling virus replication; however, because HIV selectively infe...ivation level directly affects the initial peak of virus in the blood stream. They further show that the steady-state viral levels in chronic infection are ...The catch 22 of immune response to AIDs viral infection
...onse to HIV infection is important for controlling virus replication; however, because HIV selectively infe...ivation level directly affects the initial peak of virus in the blood stream. They further show that the steady-state viral levels in chronic infection are ...Experimental smallpox vaccine protects against monkeypox in nonhuman primates
...ternative vaccine to Dryvax, which contains a live virus called Vaccinia that carries a high risk of advers...s concern that undisclosed reference stocks of the virus may exist, and its potential as a biological weapon has led to the production and stockpiling of sma...Pioneering flu researcher wins major Imperial scientific award
One of the UK's leading experts on the influenza virus is this year's winner of the Ernst Chain Prize, an...rst deciphered the molecular detail of how the flu virus latches on to and infects a cell, and subsequently how the virus evolves to stay one step ahead of t...Device detects, traps and deactivates airborne viruses and bacteria
...tors have tested the device using non-potent polio virus and have achieved 99.9999 percent efficiency. He currently is collaborating with the Midwest Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research (MRCE) and his Washington University colleague, Lars Angenent, to ide...Common virus may contribute to uncommon bone disease in children
A common virus may play a major role in causing a painful disease...h Langerhans cell histiocytosis (LCH), compared to virus detected in only five of 19 children without LCH. The research team, led by John P. Dormans, M.D., d...Rb protein's role in retina development is key to understanding devastating eye cancer
... still developing in newborn mice. The team used a virus to insert a gene for E1A--a protein that inactivates Rb--into newborn mice. The retinas in these newborn mice grew abnormally large and failed to develop rods. "Our work has also included efforts to develop a mouse model that has the same genetic mut...Scientists urge caution when releasing engineered organisms into environment
...awaii found that inserting genetic material from a virus that nearly decimated the state's papaya plantations into the plant's genome provided papaya trees with resistance to that very same virus. Genetic engineering is a powerful alternative to classic breeding the ages-old method used to give organisms ...