Viral immunosuppression: Not just a game of hide and go seek
...te demonstrate that a lymphocytic choriomeningitis virus (LCMV) strain can suppress immune responses by tar...ing LCMV infection and the novel way in which this virus not only eludes specific immune surveillance, but actively suppresses the immune response....JCI table of contents, March 1 2004
...te demonstrate that a lymphocytic choriomeningitis virus (LCMV) strain can suppress immune responses by tar...ing LCMV infection and the novel way in which this virus not only eludes specific immune surveillance, but actively suppresses the immune response. TITLE: Vi...Dana-Farber scientists discover natural blocker of HIV-1 virus
...hat blocks infection by the human immunodeficiency virus (HIV-1). The finding could lead to improved animal...n a key step in the process, the inner core of the virus sheds its capsid a protective coating that encloses the virus' genetic material and replication enz...UNC study may improve gene therapy safety
...s asking what happens to the genome if a vector or virus comes into the cell." In their experiments on cult...ne expression. Exposure to AAV either as an intact virus or as a recombinant vector shell affected gene expression minimally and in patterns not associated w...HIV exhausts the immune system through chronic non-specific activation
...is these opportunistic infections, rather than the virus itself, that make HIV so deadly. Victor Appay and ...hronic (and usually benign) pathogens, EpsteinBarr virus and cytomegalovirus, showed significant activation levels during HIV acute infection. And as HIV/AID...Tips from the Journals of the American Society for Microbiology
...o RNA is a plus-strand RNA of a novel picorna-like virus and that the brains of aggressive workers are infe...Nomoto, T. Kubo. 2003. Novel insect picorna-like virus identified in the brains of aggressive worker honeybees. Journal of Virology, 78. 3: 1093-1100.) ...Key advance reported in regenerating nerve fibers
...erapy technique. Using a modified, non-infectious virus as a carrier, they transferred a gene developed by co-investigator Dr. Zhigang He into retinal nerve cells that effectively removed the "braking" action of the myelin proteins spurring production of a molecule that sopped these inhibitory proteins u...Approved drug blocks deadly anthrax toxin
...igned to inhibit an enzyme used by the hepatitis B virus to make copies of itself. Researchers in Tang's l...mes greater than its attraction to the hepatitis B virus enzyme it was designed to inhibit. Because the drug is such a precise match to its target, it may re...Studies offer new insight into HIV vaccine development
...of HIV by training the immune system to attack the virus where it's most vulnerable. The work appears along... Center. Watkins' team produced an "escaped" AIDS virus that mimicked events that occur in HIV infection when the virus mutates to become unrecognizable to ...Athletics, genetic enhancement and ethics
...wth factor. The scientists injected a recombinant virus that contained an IGF-I rat gene into a hind-leg muscle (the flexor hallucis longus) of rats. The gene increases production of the growth factor IGF-I, which promotes gains in muscle strength and mass. Genetically enhanced rats that worked their way...Surveillance and containment would be effective intervention against deliberate smallpox attack
... also concluded that even if a particular smallpox virus were altered to cause more serious, or hemorrhagic cases than the ordinary virus, surveillance and containment would still be effective, although more deaths would occur. In an earlier study ( Science , Nov. 15 2002), the researchers concluded that...Data shows FUZEON does not increase lipodystrophy in pre-treated HIV patients
...s, acting outside the immune cell and blocking the virus before it can enter. Based on the results presented at CROI, Roche is exploring clinical research to assess the benefits of adding FUZEON to nucleoside sparing regimens designed to decrease toxicities associated with HIV treatment. This approach is b...Scripps scientists say genetic mutation doesn't protect against HIV and plague
...scent that protects against human immunodeficiency virus (HIV) is wrong. The hypothesis suggests that the mutation conferred resistance against bubonic plague in the Middle Ages, much as it does against HIV today. This idea was based on the fact that the mutation first appeared around the same time that t......ther common biological structures, such as a small virus or a cellular ribosome. Making the octahedron fro...s could be inserted -- something Joyce likens to a virus in reverse, since in nature, viruses are self-assembling nanostructures that typically have proteins...Researchers determine reason for deadly spread of 1918 influenza
The explosive spread of the influenza virus during the 1918 pandemic that killed some 20 milli... while retaining the basic properties of the avian virus from which it evolved. According to the researchers, although their findings do not apply to the new...Scientists at Scripps Research Institute describe structure of receptor on surface of 1918 flu virus
...otein from the deadly 1918 "Spanish Flu" virus-- a virus that took more lives than World War I and became t...ace protein is the first structure of this extinct virus to be solved. Their research will be published in an upcoming issue of the journal Science . A D...Natural killer cellers are made, not born
...in-Barr also is a human cancer-causing virus. The virus transforms the immune system's B cells in an elabo...stein-Barr virus. "We have seen that Epstein-Barr virus transformation of B cells can be delayed by a strong natural killer cell burst," says Mnz. "Now we a...'Kissing' RNA and HIV-1: Unraveling the details
...e in the molecular machinery for making HIV-1 (the virus that causes AIDS) has been identified by scientist...ar kiss." This structure is then packaged into new virus particles, which undergo further maturation after release from the infected cell. CARB scientists fo...Researchers discover that a virus can naturally target and kill tumors
...y School of Medicine found that one mosquito-borne virus automatically targets and kills tumor cells in mic...ancer. This study involved tumors in mice, and the virus has yet to be tested in humans. Daniel Meruelo, Ph.D., Professor of Pathology at NYU School of Medic......dermatitis--selectively kills vaccinia, the living virus in the smallpox vaccine. The virus is a relatively benign cousin of variola, the virus in smallpox. The researchers believe LL-37 may b...