Tag: "vitro" at biology news

Trojan Horse Virus Controls Hiv Infection

...for controlling disease." "Although additional in vitro and animal studies need to be performed beforethis novel virus can be tested in humans," comments NIAID Director Anthony S.Fauci, M.D., "this concept of cell-targeted delivery has enormous potentialapplications for HIV, cancer or other diseases." In...

Researchers Discover New Genetic Risk For Alzheimer's Disease

... for theamyloid protein. With what we know from in vitro studies, it would make sensethat APOE is inducing more of the normally soluble amyloid to deposit in thebrain as plaques," Goate explained. "I think this is the first result that hasreally suggested a connection between APOE expression and amyloid de...

Fauci: New Findings Help Explain "Rebound" Of HIV In Patients Who Discontinue Triple-Drug Therapy

...ne system cells." In a series of in vitro experiments, the NIAID researchers found that indu...ago symposium, Dr. Fauci will present data from in vitro experiments involving latently infected CD4+ T cells drawn from HIV-infected, HAART-trea...

Candidate Regulator Of The Temporal Component Of Neurotransmitter Release Identified

...s are located. Peptides that were inhibitory in vitro also inhibited synaptic transmission at the giant synapse, indicating that unperturbed NSF-function is essential for neurotransmitter release. Unexpectedly, the NSF peptides also delayed transmitter release, i.e. the postsynaptic response...

Insights Into The Proteasome - A Fascinating Macromolecular Machine For Protein Degradation

...tem, which allows to monitor its biogenesis in vitro . Rhodococcus a - and b -subunits spontaneously associate when brought together, and form half proteasomes. These inactive intermediates dimerize to preholoproteasomes, which in turn are converted to active holoproteasomes through ...

Rapid Progress Reported On New Class Of Anti-Cancer Drugs

...xicity in many animal models."Also, Casey said, in vitro studies had revealed that FTase inhibitors worked ona far broader range of human cancer cells -- about 40 percent of those tested --than was expected. Such broad action implies not only that Ras is central tomany cancers, but probably that a broad ra...

Wistar Research Yields Information About Colorectal Cancer Cell Invasion

...at the mEGP antigen inhibitstumor cell invasion in vitro and metastases in vivo. The same in vitro effectsare seen in humans with the GA733 antigen. Colorectal cancer cells (CRC) produce an abundanc...

UB Fertility Researchers Find They Can Predict Pregnancy By Assessing Two Sperm Abnormalities

...ral pregnancies, intrauterine inseminations and in vitro fertilizations (IUI/IVF), or no pregnancies. Results showed a very low incidence of chromosomal decondensation or acrosome reaction in the natural pregnancy group, while in the no-pregnancy group, the rates for both errors were significantly ...

Researchers Demonstrate That COX-2 Inhibits Angiogenisis In Tumor Cells

...ed. These studies were carried out in an in vitro model of angiogenesisinvolving a chamber with colon cancer cells on the bottom and endothelial cellson the top, separated by a porous collagen membrane. In a series of experiments, the researchers first compared colon cancercells that overexp...

Fauci To Present New Insights Into HIV Latency At 12th World AIDS Conference

...ients are receiving," Dr. Fauci says. "In our in vitro studies, we haveshown that it is indeed possible t... not completely eliminate the virus. "Further in vitro studies, as well as clinical trials with HIV-infectedpatients, will help determine the feasibility o...

The Perils Of Discontinuing Therapy: Without HAART, Cytokines Stimulate HIV From Latently Infected Cells

...ted,resting CD4+ T cells," says Dr. Chun. "Our in vitro findings help explain thewell-documented phenomenon of viral rebound seen in virtually all patients withno easily detectable virus in their blood as a result of HAART who discontinuetherapy." The researchers found that the cytokine combination activa...

Diabetes Drug And Accutane Block Breast Cancer Cell Growth, Cedars-Sinai Researchers Find

...r. Koeffler said. Since results of the in vitro (laboratory) and animal experiments weresuccessful, preliminary research has begun to determine whether the drugcombination is successful in humans. The first patient with prostate cancer hasbeen enrolled in a study of troglitazone, and a small tria...

New Evidence For Growth Factor Role In Crohns Disease

...inthe areas of fibrosis. Lund says more recent in vitro laboratory experiments inher UNC physiology lab support the concept that IGF-I "could be a culprit infibrosis formation, causing bowel cells to make more collagen and to growinappropriately." Still, as Lund points out, such findings don't tell ...

Cubist Pharmaceuticals Describes New VITA™ Technology For Enabling Genomics For Drug Discovery

...ng the successful inhibition of bacterial growthin vitro and the protection of mice against a lethal infection by the regulatedintracellular expression of a peptide inhibitor of an essential target. "Other target validation technologies, such as gene knock-out studies, antisenseinhibition of RNA and riboz...

Plant-Based Fat Inhibits Cancer-Cell Growth By Enhancing Cells Signaling System, UB Researchers Show

...s supplemented human prostate-cancercell tissue in vitro with either cholesterol or B-sitosterol and monitored cellgrowth. They also measured activity of the secondary messenger enzymes. Results showed there were 28 percent fewer cancer cells after five daysof B-sitosterol treatment, compared to t...

Fred Hutchinson Cancer Research Center And Targeted Genetics Announces Issuance Of Braod Patent Covering Antigen-Specific T Cell Expansion

...42entitled " Rapid Expansion Method ("REM") for in vitro Propagation of TLymphocytes." The patent covers technology used to expand antigen-specific T cells for use inadoptive immunotherapy techniques, which has the potential to treat diseasessuch as cancer as well as viral infections. This technology was...

UNC Researchers Reduce Arthritis Severity By Turning Off Molecular Switch

...ed NF-kappa B is needed to protect cancer cells in vitro from apoptosis,or programmed cell death." From their subsequent in vitro studies, Makarov and his colleagues learned thatsimilar mechanisms might operate in rheumatoid arthr...

Mouse Study Trumpets New Way To Preserve Species

...he elephant egg, in theory, could be fertilized in vitro and then transplanted into a female elephant. Howe...own," Critser says. "Using methods such as in vitro fertilization and embryo transfer for an animal requires detailed knowledge about the animal's physi...

EMAP II: A Cytokine Regulated By Apoptosis

... EMAP II precursor protein was investigated in vitro . It could be shown that following the induction of apoptosis, the EMAP II precursor protein was cleaved and the mature EMAP II released from the cell, whereas the induction of necrotic cell death had no effect on the processing of the EM...

LSU Ag Center Program Focuses On Helping Animals Reproduce; Graduates Assist Humans, As Well

... which means freezingembryos for later use, and in vitro fertilization, which means fertilization ina test tube or on a dish under a microscope. Godke and his graduate students have played a major role in bringingabout the practical use of all of these techniques. In the mid-1970s, hisprogram, alo...

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