Science-Based Decision Guide May Be Answer To EPA's Controversial Rule
...cides when extracted fromtheir hosts and tested in vitro and in the environment, such as nicotine,scorpion toxin, spider venom, and crystalline Bt endotoxin. The EPA's proposed rule will not only financially burden land grantuniversities and small companies developing pest-resistant plant varieties...How Super Are The "Super Aspirins"? -- New COX-2 Inhibitors May Elevate Cardiovascular Risk
...prostacyclin in healthy individuals. Subsequent in vitro research in other laboratories, however, indicates that blood flow stimulates the expression of COX-2 by blood vessels. The Penn results suggest that the same is true in vivo. Excessive aggregation of platelets can lead to thrombosis, dangero...Vasta To Address Diseases Of Marine Environment At AAAS Meeting
...tion from one generation to the next. PCR is an in vitro method to synthesize specific DNA sequences.) Development of specific and sensitive diagnostic molecular tools for earlydetection of pathogens in the environment will help to improve disease controland management in fisheries and aquaculture, Vasta s......ategywhich monitors early endosome fusion in an in vitro assay. In order to furtherinvestigate which of the...ncrease of EEA1 concentration in the minimalist in vitro system. It was found that EEA1 actually bridges membranes and thisknowledge now changes our view of ...Better Binding Through Chemistry
...act, when one mixes cyclosporin andcalcineurin in vitro , there's no detectable binding. But when you havecyclosporin presented by a protein called cyclophilin, there is perhaps amillion-fold increase in binding affinity to its target." In a study published in the March 2, 1999, issue of the Proceedings...Scientists Discover Function For Type III TGF-Beta Receptor
...ation. "If we use experimental techniques in an in vitro assay to block this receptoron those cells, they don't transform," Barnett said. "Conversely, if weintroduce this receptor into cells that normally would not respond-the neighborcells, they do transform in response to TGF-beta." The findings provide......e itself. Indeed, by developing asophisticated in vitro assay process to accurately gauge gene expression, theresearchers were able to describe new aspects of the step-by-step process thatoccurs as part of the biochemical deterioration of muscle cells in limb girdlemuscular dystrophy and, perhaps, all oth...Emory University Scientists Demonstrate New Pathway For Genetic Mutations In Everyday Cell Life
...occur in vivo(within live organisms) as well as in vitro (in a test tube), the Emoryscientists used the protein luciferase -- which emits the light that makesfireflies glow -- as a "reporter" to measure the effects of DNA damage on cells. They inserted the luciferase gene into two different types of E....Taking The Animal Out Of Animal Testing
...nts impact many areas of cell researchincluding in vitro toxicology, and understanding a cell's metastatic potential.Live cells are electronically "cultured" in tiny trays equipped with eightholding bays with its own low alternating current delivered via a tiny goldelectrode. When electricity is present a ...Plant-Based Fat Inhibits Growth Of Breast-Cancer Cell Line, UB Researchers Show
... cancer cells in vitro, alsoinhibits the growth in vitro of one line of breast-cancer cells, University atBuffalo nutrition researchers have found. The study, presented at the annual meeting of the Federation of AmericanSocieties of Experimental Biology earlier this month, showed that thephytoster...Cystic fibrosis gene undetected in screening of infertile men
...tic fibrosis. "Dramatic advances in surgery and in vitro fertilization have given many menwith infertility an opportunity to father children, which they could not havedone 20 years ago," says Jarvi. "But we're now finding out that we may beputting some of these children at a higher risk of being born with...UT Southwestern researchers find lever involved in ultrviolet-ray sensitivity
...lth anddisease," said Russell of the work, done in vitro and in live yeast, whichinvolved genes also found in humans. "This is a seminal finding about therelationship between the proteasome and the repair complex. The knowledge willlead to new insights into both systems." The team of investigators ...Fathers pass infertility to sons
...d that sons conceived with the aid ofa popular in vitro fertilization technique can inherit the same geneticdefects that rendered their fathers infertile. HHMI investigator <AHREF="http://www.hhmi.org/science/genetics/page.htm">David Page of theWhitehead Institute for Biomedical Research at Mas...Linezolid is highly effective against antibiotic-resistant infections
... to that of vancomycin. Based on these in vitro results, as well as his clinical experience withthis drug, Noskin commented: "Linezolid appears to be a promising new antibioticfor the treatment of a wide range of gram-positive infections, includingvancomycin-resistant enterococci." Noskin ...Immune molecule found to kill indirectly by closing receptor to live-saving help
...ana-Champaign. The team's findings are based on in vitro experiments with neurons cultured fromnormal mice. In mammals, IGF induces muscle protein synthesis, enhancing growthand weight gain, except in the presence of TNF, which is produced by immunecells in both the immune system and the brain. In neuron...Natural repellant in Spanish cedar leaves could help tropical forests
...re providingfield observations rather than mere in vitro (laboratory) evidence that insectsactually reject leaves containing these substances. We hope our findings willhelp in the protection of endangered primary forests in the tropics by promotingeconomically viable alternatives for timber production." St...New findings point to new target to block angiogenesis
... were not limited to cultured cells."All of our in vitro observations implicating thromboxane A2 in a COX-2 mediatedresponse were borne out in vivo," Daniel said. "Whether this will be true inother neovascularization contexts still needs to be determined." The studies suggest that thromboxane A2 receptor ......ich the researchers call Z-15, has demonstrated in vitro that it is an excellent spermicide and that it inhibits HIV, yeast infection, herpes, and other sexually-transmitted diseases (STDs). "This is a product with a lot of potential that we will continue to work with to improve its activity against STDs,"...Bionumerik reports data on two novel supercomputer engineered anticancer agents
...tumor activity of BNP1350 has been confirmed in in vitro models of human prostate, breast, lung, colon, melanoma, glioblastoma and ovarian cancer cell lines. Experimental observations suggest the presence of a BNP1350 dimer complex that is believed to be responsible for protecting a key chemical "lactone...Nearly identical controls of immune genes in mice and humans hint at new asthma treatment
...n Ils were expressed faithfully in CD4+ T cells in vitro and in vivo. These data support the existence of conserved regulatory elements near the cytokine cluster itself that enables the activation and/or stable expression of the type 2 cytokine genes in a cell- and lineage-specific manner." The resulting ...