Phase II trials of second-generation antisense cancer drug planned following successful early study
...be used in patients are soon to be underway in the wake of a successful Phase I study, which has demonstrated that the new drug blocks its target gene in exactly the way it is designed to do. In the Phase I study the drug OGX-011* inhibited the production of clusterin, a protein that protects cell survi...Veterans with Gulf War syndrome have damage in specific, primitive portion of nervous system
...at process, which is why we feel refreshed when we wake up," Dr. Haley said. "Its failure to increase at night in ill Gulf War veterans may explain their unrefreshing sleep." The tests were conducted on 40 members of a Naval Reserve construction battalion, also known as Seabees. Both ill and healt...A long-necked sea predator from China described in Science
...d though the water. By swallowing its own pressure wake that would otherwise signal its approach, the predator may have executed almost undetectable strikes at unsuspecting fish. While it's difficult to add muscles to a fossil when there is little or no evidence for muscles in the fossil record, and even...NASA data shows hurricanes help plants bloom in 'ocean deserts'
...ed satellite observation of this phenomenon in the wake of hurricanes," Babin noted. "Because 1998 was the first complete Atlantic hurricane season observed by this instrument, we first noticed this effect in late 1998 after looking at hurricane Bonnie," Babin said. The study found the physical make-up of...Promising research: From employment issues to virology
...r. Ekkehart Frieling, University of Kassel) In the wake of European unification, the question of Europe's cultural identity is being dis-cussed intensively. In the new Priority Programme "Integration and De-integration of Cul-tures in the European Middle Ages", researchers are questioning the theory of Eu...Leading science, higher-education and engineering groups urge six improvements to U.S. visa quagmire
...h emerged from heightened security concerns in the wake of terrorist attacks. "We are resolute in our support of a secure visa system and believe that a more efficient system is a more secure one," the groups said in a statement routed to U.S. policymakers. "We also are confident that it is possible to ha...World's oldest modern hummingbirds described in Science
...u can see the Old World hummingbirds' evolutionary wake in certain plants growing in Africa and Asia today, including a species of Impatiens . Hummingbirds and some Old World plants may have evolved together, to suit each other's needs. This process of coevolution could explain the beak-friendly flowers...New research outlines public health consequences
...rm health consequences of asbestos exposure in the wake of the disaster. Asbestos, principally chrysotile, was used in the construction of the North Tower during the early 1970's. While some of this asbestos had been removed over the preceding 30 years, hundreds of tons remained on September 11 and were b...U.S. President's budget proposal means 5-year cuts 'well below historic levels'
...umi said. Discretionary Defense Spending In the wake of military action in Iraq and Afghanistan, there have been spectacular increases in defense discretionary spending after nearly a decade of relative restraint in the 1990's. Koizumi adds, to reduce the amount of discretionary spending, the president...UT Southwestern research halts narcolepsy symptoms
...ain cells. Without these neurons, the mice did not wake up to feed as normal mice did, and they also exper...bsence of orexin-producing neurons. Also, the mice wake up, but do not try to regain that lost sleep, which is important with respect to therapeutic applica...AGU journal highlights - 6 January 2004
...] or less) seen during summer generate a turbulent wake below the ice sheets that extend hundreds of meters [yards] downstream and help mix warmer fresh meltwater with cooler saltwater. They then analyzed the strong differences estimated to occur between the summertime ice keels and the deeper wintertime ...Little-studied waves in the heart may be cause of defibrillation failure
...ped wave with a weaker stimulus and sent it in the wake of the first. "If you timed it just right you could find that the second wave would hesitate and then split in two," Wikswo continued. "One half would get smaller and slowly die, while the other half would sharply increase and eventually become a sel...A human hormone, combined with a full stomach, offers clues for understanding our food intake
...-- has acquired a greater sense of urgency in the wake of America's obesity epidemic. As scientists look for ways to help us battle the bulge, a new study suggests that our own hormonal makeup may offer promising clues. A team of researchers has tested the hypothesis that gastric distension in humans can...Salk News: Institute receives $30 million gift
...new scientific initiatives." The gift comes in the wake of a series of significant research accomplishments at the Salk Institute. During the past several months, Salk scientists have made significant advances in the understanding of Alzheimer's disease, Lou Gehrig's disease, AIDS, obesity, heart disease ...A bird in a tree for biodiversity
...abitat fragmentation. "I think what we see in the wake of the Industrial Revolution, the spread of intensive agriculture and the fragmentation and elimination of forests, is what could be an even faster series of extinctions, measured only in a couple of centuries, in which an awful lot of the world's fl...Is there an unexpected price for late night high tech excitement?
...of the experiment, the subjects were instructed to wake up between 0800 and 0900 and go to bed between midnight and 0100 to maintain regular sleep-wake cycles. The average times when the subjects went to bed and woke up were 0045 and 0816, respectively. Furthermore, beginning three days before the experim...Fear of 'foreigners' may slow scientific progress
... shaken U.S. government tightened visarules in the wake of terrorist attacks, thebacklog of visa applications from young scholarslike Hassan has continued to grow--from 1,000cases tagged for review during 2000 under the code-named MANTIS program, one of several U.S.screening checkpoints, to 14,000 in 2002...Troubling news about sea otter deaths
...dy. The findings are particularly worrisome in the wake of last week's report that a startling 100 southern sea otters have washed up dead on California beaches since January -- 100 deaths in a population that has been falling overall since 1995 and now stands at about 2,000. The new analysis, done in co...AAAS analyzes federal R&D 2004 budget
... a 3.2 percent increase (to $5.5 billion). In the wake of the Columbia shuttle disaster, NASA's budget would rise to $15.5 billion, however, Koizumi adds that the budget will have to be reallocated or augmented in the coming weeks because non-R&D programs, of which the largest is the Space Shuttle, would...Using the ocean's living light shows to fight terrorism or track the planet's most massive migration
... bioluminescent organisms to give off light in the wake of a ship or submarine. If the Navy could reliably predict such events it could, for instance, increase the safety of covert missions. Though progress has been made, such a feat has proven difficult because the vast soup of sea creatures involved r...