Tag: "withdrawal" at biology news

Imaging Studies Illuminate Brain's Response To Cocaine

...tivated during the different stagesof drug use and withdrawal can help us design and monitor novel treatments,"says Steven E. Hyman, MD, director of the National Institute of Mental Health. Previously a member of the MGH Psychiatry Service, Hyman also is senior authorof the Neuron paper. In studying the reacti...

Rapid Progress Reported On New Class Of Anti-Cancer Drugs

...r is nevercompletely killed. In the model systems, withdrawal of the drug caused the tumorto return, which means that cancer patients would have to remain on the drugs. "Such long-term therapy means that cancers could become resistant to theinhibitors, which makes it especially advantageous that many co...

Neurogenetics Lab Scan Suggests Genetic Linkage On Chromosomes 4 And 11

...ect believed to influence intoxication, tolerance, withdrawal severity, and cognitive effects of alcohol consumption, and researchers long have suspected that variant forms of GABA receptor genes may contribute to alcoholism vulnerability. To determine whether this GABA receptor gene is responsible for the chro...

Hopkins Study Shows Languishing Addictions Drug Really Works

...in its capacity to discourage heroin use and block withdrawal symptoms. However, unlike methadone, which addicts must use daily, LAAM can be taken three times a week, making it far more convenient and potentially less expensive. LAAM isn't widely used, because of both uncertainties about how effective it is ...

Inherited Depression Linked To Shortage Of Cells In Brain Region

...bly similar to depression, wherepeople show social withdrawal and lack of activity." The researchers now want to determine which type of glia is in shortsupply and what the consequences could be. "By studying the causes and resultsof these changes, we might be able to explain in the future how depressio...

Researchers Externally Regulate Gene Implanted In Brain

...ould be regulated in the brain byadministration or withdrawal of doxycycline. "Control of gene expression, its protein production, is of particularimportance in gene therapy. And one of the hallmarks of AAV is that it can lastfor a very long time at a sustained level," Haberman says. She and hercolleagu...

Gene Therapy For Pain

...r type of super-sensitive pain results inrapid paw withdrawal and is used as a model for the chronic pain of can... observation that the non-inflamedpaw had a normal withdrawal response. This points not only to a lack oftoxicity from the treatment procedure but also to a sele...

Researchers develop first potential schizophrenia genetic animal model

...nations, delusions, otherwiseimpaired thinking and withdrawal from people. Compared with earlier times -- when patients could be institutionalizedfor life -- treatments have improved markedly, especially in recent decades, shesaid. Still, drug therapy fails in some people and can carry undesirable sidee...

Study confirms safety and tolerability of zaleplon for long-term treatment of insomnia

...used safely for up to one year,without causing any withdrawal symptoms upon discontinuation." Approximat...ofawakenings, and sleep quality. The incidence of withdrawal syndrome (acondition that often occurs after prolonged treatment with a sedative orhypnotic -- the c...

Smells may trigger alcohol craving, and relapse, among alcoholics

...hat may "reinstate alcohol-seeking behavior" after withdrawal and abstinence. In other words, smells may trigger craving for alcohol, which could lead to relapse. "Addiction is essentially a chronic relapsing disease of the brain," said Friedbert Weiss, Associate Professor in the Department of Neuropharmacolo...

How alcohol gives, and then takes away

...ing more than moral support as the very process of withdrawal could damage the neurons." Tabakoff spoke of developing drugs that will protect the neurons, returning the individuals' pleasure systems to normal while avoiding irrevocable damage. Morrisett indicated there is a need for future studies that look at...

This is your adolescent brain on alcohol

...rt and Brown's study had to do with a link between withdrawal experiences and adolescent neuropsychological functioning. For example, youth who had shakes, headaches or vomiting after a heavy-drinking episode were more likely to have poorer test results. The reasons for this association are unclear. Tapert a...

Binge drinking: a dangerous rite of passage

...ritically involved in learning and memory. During withdrawal from alcohol, NMDA receptors can become overly active, which can make the brain more vulnerable to cell death. We are currently investigating whether adolescent brains exhibit greater withdrawal-induced hyperactivity at NMDA receptors than adults, a...

Caffeine in colas: 'The Real Thing' isn't the taste

...pendent on caffeinated soft drinks, experiencing a withdrawal syndrome if they stop," says Griffiths. Earlier research at Hopkins shows that withdrawal symptoms typically include headache and lethargy, and last a day or two. "Most adults can become in...

More than 300 regularly prescribed medicines can damage the lungs

... Florence, because in about 70% of cases the early withdrawal of the medicine would increase the patients chances of avoiding the damaging sequelae, and very often the medicine concerned could simply be replaced with another. Impressive lists Yet the Dijon team has put together a unique, regularly updated Inter...

Tipsheet: Journals of the American Society for Microbiology

..., after which replication can be turned off by the withdrawal of doxycycline," say the researchers. "In case a booster vaccination is required to mount an optimal immune response, replication can be switched on transiently at later times by [administering] doxycycline." (K. Verhoef, G. Marzio, W. Hillen, H. Bu...

Pollen record from Chilean lakes indicates global "togetherness" during last ice age

...revious research by the same team showed an abrupt withdrawal of Andean piedmont glacier lobes 14,600 years ago at the same time northern ice sheets were retreating. Our results suggest that mid-latitude climate in the Southern Hemisphere changed in unison with the North Atlantic region. We are continuing to ve...

Geologists explore beach nourishment controversies, groundwater quality, and Blue Ridge mountain issues

...rivers, and other bodies of water. Restrictions on withdrawal of water from deep aquifers have also forced development of aquifers nearer to the surface. This study illustrates the potential impacts of near-surface aquifer development on wetlands preservation, nitrate concentration, and the state's goal of redu...

Abnormalities in stress hormone response among alcoholics

... serotonin function, and both smoking and nicotine withdrawal have been associated with changes in LHPA axis function. Similarly, approximately 15 to 20 percent of alcoholics have antisocial personality disorder (ASPD), defined as a life-long pattern of impulsiveness, aggression, and a general disregard for th...

Abstinence may make the brain grow stronger

...ies need to take into account nutritional factors, withdrawal symptoms, and functional outcomes in alcoholic men and women of all ages. This is in fact what Meyerhoff and his colleagues have in the works: longitudinal studies of alcoholics who undergo treatment for their drinking problem. "These studies are on...

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