Dr. Francis White, FUHS/CMS, receives MERIT Award
...equences of repeated administration of cocaine and withdrawal from cocaine dependence in animal models, (2) correlating those behavioral alterations with specific neuroadaptations occurring in dopamine and related neuronal systems, (3) identifying the roles of dopamine receptor subtypes in specific functions me...A new approach holds promise for reducing cocaine craving
...lunge to about half their normal level. During the withdrawal stage, injections of small amounts of cocaine produce large increases in glutamate concentrations, but only for short periods. The Kalivas group has located a novel target of cocaine's action: a special protein complex, called the cysteine-glutamate ...Cocaine harms brain's 'pleasure center,' addict study finds
...ased motivation, stunted emotion and uncomfortable withdrawal they face. In recent years, many researchers have come to suspect that chronic cocaine use causes the brain to adapt to the drug's presence by altering the molecules involved in dopamine release and reuptake, and in the genetic instructions needed to...B-vitamins prove effective in relieving chronic pain
...rmal hyperalgesia was determined by measuring foot withdrawal latency to heat stimulation of surface of hindpaw....enced by reversal of the shortened latency of foot withdrawal to noxious heat stimulation ipsilateral to CCD. This inhibition was in dose-dependent manner. Hypera...Study finds two-thirds of unplanned pregnancies in women using contraception
...th among those using natural methods, such as male withdrawal or avoiding intercourse on fertile days in the men...ationships within a couple, the use of condoms and withdrawal methods may be problematic. "There is no reason to think that what we found in our study is not more...Chronic alcohol abuse damages regulating hormones
...ing complications and liver insufficiency. Alcohol withdrawal and early abstinence also wreak havoc on alcoholic... balance in the body may not only account for some withdrawal symptoms but persist over long periods of strictly controlled abstinence. Although it is well known...Organization for Human Brain Mapping annual meeting abstract highlights
...and emotional stimuli; their gaze aversion, social withdrawal and shynessare often accompanied by disturbances in social communication and interactions. This study suggests that these deficits may be related to differences in central brain mechanisms responsible for the processing of social and emotional stimu...Women who drink may be at greater risk of cardiovascular complications than men
...ere then divided into subgroups according to their withdrawal blood pressures: those with transitory hypertensio...l, and those with normal blood pressure throughout withdrawal and treatment. "The women with tHT showed dysfunction across most of the cardiovascular measures," ...Study calls for cheaper antitoxins for plant poisoning in less-developed countries
...ted the effect of the antitoxin's introduction and withdrawal on case fatality, and determined its cost-effectiveness. They report how the antitoxin strikingly reduced the case fatality; its absence resulted in a three-fold rise in deaths. At the present price of US$2650 per course, every life saved cost around...LabNotes -- Research highlights from Pacific Northwest National Laboratory
... evaluate diverse scenarios such as drinking water withdrawal from urban lakes, or the effects of changes in the urban growth boundary. The system will include models of water resources as well as those used to evaluate ecological and human health risks. PNNL researchers hope to develop a system that can be app...Tip sheet for the November 25, 2003 Neurology journal
...nd physiological symptoms - signs of addiction and withdrawal - in five people without PD who were weaned off levodopa. This suggests that levodopa can be very addictive, and could explain PD patients' impatience with waiting for their next dose. A "Patient Page" article on Myasthenia Gravis and pregnancy will ...Scripps Research receives $3 million anonymous donation
...n that GABAergic activity decreases during alcohol withdrawal and protracted abstinence. Another target for the...ock the excessive drinking associated with alcohol withdrawal and protracted abstinence. The center will aim to discover and test new CRF antagonists and other c...Researchers find an association between alcohol dependence and the GABAA receptor gene GABRG3
...cohol, such as motor incoordination, sedation, and withdrawal signs, while chemicals that block GABAA receptors lessen these effects." For this study, Dick and her colleagues decided to focus on GABAA receptor genes on chromosome 15q because of earlier findings from the multi-site Collaborative Study on the ...Adolescent rodents experience milder hangover effects than do adult rodents
...apprehension, is one of the psychological signs of withdrawal from alcohol in alcohol-dependent humans. The more commonly recognized signs of withdrawal are physiological in nature, such as a rapid heartbeat, increased blood pressure, sweating, nausea, ...Scripps scientists describe dangerous cocktail of alcohol, brain peptides, and neurotransmitters
...n that GABAergic activity decreases during alcohol withdrawal and protracted abstinence--the initial post-acute withdrawal period after the cessation of drinking during which a person is especially vulnerable to relapse. Th...Alcoholism risk linked to gene involved in brain chemistry
...physical coordination, effect on mood, and alcohol withdrawal symptoms. Alcoholism, which affects nearly 14 million Americans and can cause many social and health problems costing society an estimated $185 billion annually, is what scientists call a "complex" disease, meaning that many genes as well as environ...Prenatal nicotine primes adolescent brain for addiction
...regnancy can show signs of nicotine dependence and withdrawal after just a handful of cigarettes," said Theodore...ened the decline in brain activity during nicotine withdrawal and led to an increase in the amount of brain cell injury induced by the drug, they reported. "The c...Landmark, pivotal Phase IIb/III trial of biotoxin for cancer pain begins
...y used the drug compound for the treatment of drug withdrawal but it was noted that the main factor in its ability to relief or eliminate withdrawal symptoms was its ability to reduce pain. Thus, Wex pursued testing of Tectin TM for refractory canc...Researchers establish first molecular link between eating and aging
...s, fat mobilization in white adipocytes. Upon food withdrawal the Sirt1 protein binds to and represses the genes that are controlled by PPAR-gamma, the fat regulator," preventing fat from being stored in the body. "The ability of fat cells to sense famine [or short-term hunger] and release the fat is regulate...