Tag: "yew" at biology news

New, Environmentally Friendly Technique For Separating Liquids Invented At UNC-CH

...atural products such as taxol, an extract from the yew tree that helps fightcancer," said Dr. Joseph M. DeSimone, Mary Ann Smith professor of chemistry atUNC-CH. "Very often these processes need to use organic solvents which are notgood for our environment. That's because the solvents are either toxic or...

Mystery Of Vital Cell Protein Solved After 30 Years

...natural substance found in the bark of the Pacific yew tree (the name"taxol" has been trademarked by Bristol-Myers-Squibb), was shown in clinicaltests to be an effective treatment for a number of cancers including ovarian,breast, and lung. Cancer occurs when cell division runs amok. By binding to tubul...

Palo Alto researcher receives national award

...to harvest for human use -- think of TAXOL and the yew tree, he said. "So our idea is basically to take out the entire genetic step from that organism and put it in a biologically friendly one that's easy and quick to grow. It's the equivalent of bringing the mountain to the prophet." Some researchers a...

Kingston named Virginia Outstanding Scientist of 2002

...ginal source of Taxol was the 100-year-old Pacific yew tree, and six trees were sacrificed to treat each patient. Kingstons work paved the way for developing a semi-synthetic process to create Taxol, according to the Science Museum of Virginia, and "laid the foundation of Taxol chemistry and provided mu...

Plant compound kills brain tumor cells

...it had to be isolated from the bark of the Pacific yew tree. However, as taxol proved clinically effective, researchers developed an alternate method of partial synthesis of the compound from a more plentiful precursor in the needles that made the drug available in sufficient supply. Beachy and his coll...

Texas chemist wins national award for vitamin, other natural products research

...axol, the anti-cancer drug originally derived from yew trees and currently made via a labor-intensive process starting with a bush related to yew. "We've found the first four or five genes, and we've gotten as far as a compound with taxol's shape and appropriate rings," he said. "I think we've got about ...

Yeast, wormwood & bacterial genes combine in microbial factory to make antimalarial drug

...roma and which also include taxol from the Pacific yew tree, and carotenoids, such as the compounds that give plants their color. Aside from their importance in flavorings, colorings and perfumes, isoprenoids from organisms as diverse as coral and fungi are being identified as potential drugs. "The abili...

New paclitaxel analog kills more cancer cells than natural product

...April 1, 2004. Paclitaxel, a natural compound from yew trees, is a relatively scarce resource, but synthetic forms and analogs have, so far, been less effective. So scientists have continued to study how the paclitaxel molecule works in order to develop more effective products. Kingston explains that pac...

Shared gene switch for all plants found

...liverworts, club moss, ferns, Douglas fir, Mexican yew and Arabidopsis, a flowering plant often used in laboratory research. Not only are the amino acid sequences of the proteins highly conserved, but also the nucleotide sequence of the microRNA binding site in the mRNA has been conserved for 400 mi...

New designed paclitaxel analog kills more cancer cells than natural product

...nstitutions. Paclitaxel, a natural compound from yew trees, is the world's best-selling anticancer drug. Several analogs are in clinical trial, with others in preclinical development. One problem that paclitaxel and all its analogs share, however, is that they are all highly complex compounds, and cann...

Chemical Society announces EPA awards for environmentally friendly technology

...el was first isolated from the bark of the Pacific yew tree. Harvesting the bark meant sacrificing the tree, which provides habitat for the endangered spotted owl. Bristol-Myers Squibb designed a semi-synthetic route to paclitaxel, using a naturally occurring compound found in the European yew's leaves a...

Sponge substance works well with yew derivative to thwart cancer cell proliferation

... sponge teams up to enhance the performance of the yew tree derivative Taxol (paclitaxel) in preventing the growth of cancer cells, according to research published in the July 15 issue of the journal Cancer Research . Indeed, discodermolide, a novel drug isolated from the marine sponge Discodermia disso...

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