Tag: "antibody" at biology news
Amgen investigational therapy, AMG 162, increased bone mineral density with twice yearly injection
... 162 is an investigational, fully human monoclonal antibody
with a unique mechanism of action that exclusively targets and binds with high affinity to, and inhibits the activity of human RANK (receptor activator of nuclear factor kappa B) Ligand, the primary mediator of bone resorption. Amgen scientists have...
New biosensor rapidly detects deadly foodborne pathogen
...fluorescent glow when exposed to laser light. This antibody
attaches to the L. monocytogenes bound to the fiber and acts as a flag, signaling the pathogen's presence when laser light is passed through the liquid. Bhunia expects the sensor to be ready for industrial use in another year. Many ...
Channel protein converts vibrations to electrical signal
...l. In frogs and mice, a fluorescently-tagged TRPA1 antibody
bound the tips of the cilia, where the mechanically activated channels were known to be located. This localization of TRPA1 changed, however, when the researchers treated the hair cells with a chemical that damages the mechanically-sensitive signalin...
Gene linked to enlargement of the factory where proteins are processed
...nd packaging is especially critical in the case of antibody
production, according to Joseph W. Brewer, assistant professor in the department of Microbiology and Immunology at Loyola University Medical Center. The cells that make and secrete antibodies--the B cells--must synthesize, fold and release thousands ...
Safety and immunogenicity data available for new pertussis booster vaccine candidate for adolescents
...dition, the use of Boostrix induced anti-pertussis antibody
levels which exceeded (by 1.8 to 6.9 times) those ...N were measured and were found to exceed pertussis antibody
concentrations observed in infants, following primary immunization with a DTaP vaccine (Infanrix ),...
Stretching the supply of flu vaccine: Solution offered in new SLU research in New England Journal
...ull dose of vaccine given as the traditional shot, antibody
responses to a lower dose vaccine given under the ... that the vaccine is doing its job in producing an antibody
response. "More and larger studies are needed to confirm these options so that agencies such as th...
UT Southwestern initiating trials in humans for ricin vaccine
...he vaccine's safety at doses that induce effective antibody
levels in healthy humans. DOR BioPharma, Inc. has received an exclusive license for the vaccine and is developing manufacturing processes for the genetically engineered vaccine. DOR is planning to produce a large stockpile for more advanced human cl...
JCI table of contents, December 1 2004
...ient serum and failed to cause an anti-ganglioside antibody
response in mice. The report demonstrates that spe... of Campylobacter jejuni genes in anti-ganglioside antibody
induction in Guillain Barr syndrome AUTHOR CONTACT: Peggy C.R. Godschalk Department of Medical Micro...
Cells don festive holiday colors
...owed" the immune system's machinery for generating antibody
diversity and used it to evolve a new red fluorescent protein. In addition to offering fluorescent proteins in a range of distinctive colors, Tsien's group has improved their design, creating proteins that are "monomers" that consist of only single ...
No blind mice, thanks to UF scientists
...ericans. Scientists explain how they used a common antibody
to block the formation of SDF-1 in the eyeballs of...Then, as a treatment, scientists injected an SDF-1 antibody
directly into the afflicted eyes. The antibody
-- which is simply another protein that binds to the ...
US researchers uncover the science behind the breast cancer protective effect of olive oil
...iveness of trastuzumab (Herceptin), the monoclonal antibody
treatment that targets the Her-2/neu gene and has helped to prolong the lives of many breast cancer patients. Lead researcher, Dr Javier Menendez, assistant professor at the Northwestern University Feinberg School of Medicine in Chicago and a res...
Weill Cornell team develops fast-acting anthrax vaccine
... to work -- telling the animal's body to make this antibody
against anthrax," Dr. Crystal said. The study fou...'s body, the gene began producing an immune-system antibody
targeted to a key component of the deadly anthrax toxin. Mice were immune to anthrax within 12 to 1...
Tips from the journals of the American Society for Microbiology
...L. Frenken, T. Verrips. 2004. Isolation of llama antibody
fragments for prevention of dandruff by phage display in shampoo. Applied and Environmental Microbiology, 71. 1: 442-450.) New Coronavirus Identified in Pneumonia Patients Researchers from Hong Kong have identified a novel coronavirus in patient...
COX-2 levels are elevated in smokers
... small molecule that inhibited EGFR activity or an antibody
that prevented ligands from binding to and activating the EGFR. These findings led us to question whether tobacco smoke initiated the process of increasing COX-2 production by first stimulating production of proteins that controlled activity of the E...
Mouse brain cells rapidly recover after Alzheimer's plaques are cleared
...ool of Medicine in St. Louis injected mice with an antibody
for a key component of brain plaques, the amyloid beta (Abeta) peptide. In areas of the brain where antibodies cleared plaques, many of the swellings previously observed on nerve cell branches rapidly disappeared. "These swellings represent structura...
Despite causes of lupus proving complex, critical 'checkpoint' suggesting new therapy is revealed
...nown for his elucidation of an important family of antibody
binding molecules called the Fc receptors, and his colleagues, have learned that a specific Fc receptor functions to prevent the accumulation of the auto-antibodies that are responsible for the disease progression in lupus. They also have discovered ...
JCI table of contents
... nerve damage in Alzheimer disease TITLE: Anti-Ab antibody
treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice. AUTHOR CONTACT: David M. Holtzman Department of Neurology, Washington University, St. Louis, Missouri, USA. Phone: 314-362-9872; Fax: 314-362-28...
Blocking cell signaling can stymie viral infections, study shows
...lpox virus, a combination of the drug and a single antibody
injection resulted in complete clearance of the lungs in just eight days. "The results demonstrate the principle that viral diseases can be effectively fought by blocking cellular signaling pathways that viruses depend on for reproduction," Reinherz ...
New neurons born in adult rat cortex
...transmitters they secreted. The markers exploited antibody
affinities for specific proteins to tag particular cell types with telltale color codes, visible on brain slices under fluorescence with a laser-powered microscope. The researchers found that the cortex and striatum were giving birth to new, widely s...
Tips from the Journals of the American Society for Microbiology
... with Avian Flu A new diagnostic test monitoring antibody
response to the NS1 virus protein may allow for di...antibody, commercial vaccines induced little or no antibody
response. "These results demonstrate the potential benefit of a simple, specific enzyme-linked immun...
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