Channel protein converts vibrations to electrical signal
...there are no known deafnesses that map to the same chromosomal location as this channel," he said, "but we are screening some unmapped deafness families." In addition to the evidence that TRPA1 forms a mechanically-gated channel in the hair cells, the structure of the protein suggests that it may play another r...Identifying genes that contribute to a low level of response to alcohol
...suming," he said. "We will be focusing on several chromosomal regions, several specific genes, and continue to collaborate with people doing animal research."...Gene for Joubert syndrom with excessive brain folds discovered by UCSD researchers and Harvard team
... work of the human genome project to arrive at the chromosomal hot-spot," he said. Noting that many children with Joubert Syndrome also have autism, Gleeson explained that "if we can understand how the AHI1 gene works and how its dysfunction leads to disordered brain development, it can tell us something about t...Molecule that helps DNA replicate may make good target for cancer therapy
...m10 brings the DNA polymerase alpha complex to the chromosomal sites where replication originates. It does this by attaching to the protein that keeps the two DNA strands from reconnecting. But what came as a complete surprise was that Mcm10 also stabilizes the polymerase alpha complex. In cells lacking Mcm10, t...ENCODE consortium publishes scientific strategy
...gene transcription; and DNA sequences that mediate chromosomal structure and dynamics. The ENCODE researchers also anticipate they may uncover additional functional elements that have yet to be recognized. "Creating this monumental reference work will help us mine and fully utilize the human genome sequence. Suc...New genomic method can identify disease-causing genes
...nates the need for follow-up studies to mine large chromosomal regions, saving researchers from months to years of experimentation. In addition, the results are assessed by absolute (p-value) statistical criteria, which give researchers greater confidence in their analyses. The pattern of genetic variation a...Gene for common form of Parkinson's pinpointed
...s caused by a mutation in a gene somewhere along a chromosomal region, or locus, that contained about 116 genes. The researchers had identified four families from the Basque region of Spain and one from the United Kingdom that showed evidence of having PARK8 PD. Their systematic analyses of the PARK8 locus l...For yeast, a DNA break ensures sex switch for a grandchild
...type. Two decades ago, researchers proposed that a chromosomal imprint at the mating-type locus was responsible for generating two rounds of asymmetric division. Now Benoit Arcangioli's group at the Pasteur Institute in Paris, France, has identified a new imprinting mechanism that controls sexual switching in ye...Sex-determining genes of infectious fungus resemble human Y chromosome
...erences, similar evolutionary processes shaped the chromosomal sex-determining regions in both groups, said HHMI investigator Joseph Heitman, M.D., director of Duke's Center for Microbial Pathogenesis. The fungus might therefore serve as a useful model system for the study of sex chromosome evolution and the gen...UCLA scientists uncork fountain of youth for HIV-fighting cells
.... "They grew at a normal rate and didn't show any chromosomal abnormalities that might lead to cancer." "We also saw that telomerase stabilized the telomere length," added Dagarag. "The telomere didn't shorten each time the cell divided, which left the cell able to vigorously battle HIV much longer." The UCLA ...New bulls may revive the Texas state Bison Herd
...after birth. Disease and genetic problems such as chromosomal defects were ruled out. But since Derr and Halbert already were sampling the DNA from the federal bison herds throughout the United States for another project, they knew how much genetic variation there should be in an "average" bison. "When we com...Stronger therapy better for AML with normal genetics
...mic cells with normal-looking chromosomes. Without chromosomal abnormalities to guide treatment, several therapies are usually used. "This study is important because it is the first large study to examine different types of therapy that is restricted to patients with normal chromosomes," says Krzysztof Mr...New drug sidesteps Gleevec resistance in human trials
...e (ABL), an enzyme that becomes overactivated by a chromosomal mix-up that occurs during blood cell development. The genes ABL and BCR, which are located on different chromosomes, become fused and express a hybrid BCR-ABL enzyme that is always active. The hyperactive BCR-ABL, in turn, drives the overproliferatio...Efforts to clone primates move forward
.... While cell division superficially seemed normal, chromosomal problems existed within each individual cell. The ...pindle abnormalities, motor deficiencies and other chromosomal anomalies were observed. Embryos created through nuclear transfer appear to be inferior to fertilize...Chicken genome analysis unlocks secrets of mammalian and bird evolution
...explore how birds and mammals differ and how their chromosomal structure and protein content have evolved. Some o... of both species contain genes that share the same chromosomal position. Expansion and contraction of gene families may be responsible for the independent evolut...UCSD bioinformatics researcher studies tumor genome architectures with career award
...r in cystic fibrosis, or they can involve multiple chromosomal rearrangements such as those associated with solid tumors." Raphael was planning to apply for a faculty position this year, but says the BWF award will afford him an easier transition. "I now have a little more freedom to do research and stay here at...Researchers discover a stem-cell switch lurking within leukemias
...agues explored the difference between two abnormal chromosomal rearrangements they thought might confer the ability to self-renew. These cancer genes cause leukemia in white blood cell progenitors that have already committed to become a particular type of blood cell, and are therefore no longer self-renewing ste...Needling chromosomes yields insights into cell division
...s chromosome imbalances that can lead to cancer or chromosomal abnormalities that cause birth defects." According to Nicklas, it was known that the two sister chromatids adhered to one another and released at the appropriate time during cell division. However, that understanding was based on biochemical experime...Fox Chase Cancer Center scientists discover key proteins linked to aging and cancer
...dings focus on the composition and assembly of key chromosomal protein complexes involved in shutting down reproduction of aging cells. The report by molecular and cell biologist Peter D. Adams, Ph.D. and his colleagues appears in the January 2005 issue of Developmental Cell. "In the lab, aging cells are called......vides further evidence supporting the concept that chromosomal inversions represent the most typical molecular le...liar susceptibility of thyroid follicular cells to chromosomal rearrangement is remarkable." This study represents a major breakthrough in our knowledge of ...