Cornell scientists link E. coli bacteria to Crohn's disease
ITHACA, N.Y. A team of Cornell University scientists from the College of Veterinary Medicine, Weill Cornell Medical College and the College of Agriculture and Life Sciences have discovered that a novel group of E. coli bacteria containing genes similar to those described in uropathogenic and avian pathogenic E. coli and enteropathogenic bacteria such as salmonella, cholera, bubonic plague is...Gene identified for Crohn's disease in children
... ... ... Because Crohns disease is complex, with multiple genes interacti...PET/CT should be 'first-step' test for patients with Crohn's disease
... "Our study is the first one demonstrating the value of PET/CT in Crohn's disease," said Roland Hustinx, head of the nuclear medicine division at the University Hospital of Lige and professor of nuclear medic...Stuck on you: CEACAM6 helps E. coli stick to intestinal lining in Crohn's disease
In Crohn's disease, the lining of the small intestine is abnormally colonized by E. coli organisms that are able to adhere to and invade intestinal epithelial cells. In a study appearing online on May 24 in advance of publication in the June print issue of the Journal of Clinical Investigation, Arlette Darfeuille-Michaud and colleagues from Universit d'Auvergne, France, show that the adherent-in...Susceptibility to Crohn's disease -- an important new clue
... In a genome-wide association study with more than 300,000 single nucleotide polymorphisms (SNPs) DNA sequence variations occurring when a single nucleotide in the...Scientists find major susceptibility genes for Crohn's disease
A consortium of Canadian and American researchers led by Dr. John D. Rioux, PhD, Associate Professor of Medicine at the Montreal Heart Institute and the Universit de Montral, report in the April 15 online edition of Nature Genetics the results from a search of the entire human genome for genetic risk factors leading to the development of Crohn's disease. Specifically, using a novel approach, th...Scientists find new genes for Crohn's disease
PITTSBURGH, April 15 Just a few months after their landmark article in Science magazine reporting the discovery of strong links between variations in a gene that codes for a cellular receptor involved in controlling inflammation and Crohn's disease, a consortium of U.S. and Canadian researchers is reporting in today's online issue of Nature Genetics that they have discovered several more geneti...Research team identifies additional genetic risk factors for Crohn's disease
An international research team including investigators from Massachusetts General Hospital (MGH) and the Broad Institute of Harvard University and Massachusetts Institute of Technology has identified several novel genetic variations associated with the risk of Crohn's disease. One of the identified genes establishes a role for autophagy, a previously unsuspected biological pathway, in Crohn's...Scientists find major susceptibility gene for Crohn's disease
... More than 150,...Scientists find major susceptibility gene for Crohn's disease
... More than 1 million Americans have Crohn's or colitis, know...Crohn's disease gene identified
... Crohn's disease and ulcerative colitis, collectively called inflammatory bowel disease (IBD), are chronic disorders that cause abdominal pain, diarrhea and gastrointestinal bleeding and affect over one million Americans. Because IBD tends to run in families and is more frequent in certain ethnic populations, especially Ashkenazi...New gene found for Crohn's disease
... More than 1 million America...Scientists find gene target that may protect against Crohn's disease and ulcerative colitis
... Montreal, October 26, 2006 The discovery by a six-member Inflammatory Bowel Disease (IBD) Genetics Consortium of a genetic risk factor for IBD has been reported in Science Express, the online publication of the journal Science. According to one of the Canadian principal investigators, director of the Laboratory in Genetics and Genomic Medicine of Inflammation at the Montreal Heart Institute...Honolulu, Hawaii, October 31, 2005 - A single 400 mg injection of Cimzia (certolizumab pegol, CDP 870) every four weeks was effective in maintaining control of the signs and symptoms of Crohn's disease following induction therapy, according to pivotal phase III research presented this week at the annual meeting of the American College of Gastroenterology.... ...The study, entitled PRECiSE 2, foun...Certolizumab pegol demonstrates positive results in two Phase III Crohn's disease trials
Atlanta, Georgia, July 26, 2005 - UCB today announced positive results for the two pivotal Phase III trials (PRECISE 1 and 2) of certolizumab pegol (CDP870) in the induction and maintenance of clinical response in moderate to severe active Crohn' ......Data from PRECiSE 1 and 2 will be presented in more detail at the major forthcoming gastroenterology medical congresses.... ... About Crohn...Pro-inflammatory protein contributes to Crohn's disease according to UCSD School of Medicine study
A pro-inflammatory protein activated by bacteria in the colon plays a key role in the development of experimental colitis in mice a mouse-version of human Crohn's disease according to research by scientists at the University of California, San Diego (UCSD) School of Medicine. ......The study, published in the February 4, 2005 issue of the journal Science, identified interleukin-1Beta (IL-1) as...This week, researchers report new findings that elucidate the role of NOD2, a key molecular player in Crohn's Disease, in the cellular signaling pathways that control inflammatory responses. NOD2's clinical relevance is clear from the fact that it is encoded by a Crohn's Disease susceptibility gene. Understanding NOD2 has posed a particularly intriguing challenge for researchers because it appear...CHARLOTTESVILLE, Va., Nov. 11, 2004 In a Perspective article in the Nov. 11 issue of the ... Patients, physicians and medical researchers need to reconsider traditional hypot...