Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
... According to the Centers for Disease Control, 7% of the U.S. population has diabetes, and 90-95% of those cases are c...ESF EURYI award winner aims to stop cancer cells reading their own DNA
A promising new line in anti-cancer therapy by blocking the molecular motors involved in copying genetic information during cell division is being pursued by young Dutch researcher Dr. Nynke Dekker in one of this years EURYI award winning projects sponsored by the European Science Foundation (ESF) and the European Heads of Research Councils (EuroHORCS). Dekker and her team are trying to stop tu...Biologist traces coconut's history through DNA
The coconut has been popular in lore and on palates for centuries, yet ...little is known about the history of coconuts domestication and ...dispersal around the world.... Now, a biologist at Washington University in St. Louis is ...embarking on the task of understanding the plants history by exploring ...the genetics of the coconut (Cocos nucifera L.).... Kenneth Olsen, Ph.D...Unknotting DNA clue to cancer syndrome
... ... Neil Hunter, assistant professor of microbiology at UC Davis, and his colleagues studied the equivalent protein in yeast, SGS1. They fo...... That question may now be closer to an answer. By comparing computer models of damaged human DNA with micro...New grants bolster efforts to generate faster and cheaper tools for DNA sequencing
... "Innovative sequencing technologies are critical to our efforts to move advances in genomic knowledge into the clinic. The era of personalized medicine wi...Hepatitis C helicase unwinds DNA in a spring-loaded, 3-step process
... Researchers at the University of Illinois, Yale University and the Howard Hughes Medical Institute have shed new ligh...Back to the future: Mastodon extends the time limit on DNA sequencing
In a new paper in the open access journal PLoS Biology, Michael Hofreiter from the Max Planck Institute for Evolutionary Anthropology in Germany, and colleagues from Switzerland and the United States, announce the sequencing of the complete mitochondrial genome of the mastodon (Mammut americanum), a recently extinct relative of the living elephants that diverged about 26 million years ago. The s...Manchester University helps with pharaoh DNA analysis
... ... Now, Dr Angelique Corthals, a biomedical Egyptologist at The University of Manchester, says that DNA tests she helped carry out with colleagues at the National Research Centre in...Chromosome glue repairs damaged DNA
... The new results are concerned with a phenomenon called cohesion, whereby two copies of a chromosome in the cell nucleus are held tightly together by a protein complex called cohesin. Cohesion fulfils an important function during cell division as the newly copied chromosomes, t...Liverpool amongst first in UK to install unique DNA sequencing technology
... ... ... Scientists from all over the UK will be able to use the new technology for a variety of differ...Unraveling the physics of DNA's double helix
... "The stability of DNA is so fundamental to life that it's important to understand all factors," said Piotr Marszalek, a professor of mechanical engineering and materials sciences at Duke. "If you want to create accurate models of DNA to study its interaction with proteins or drugs, for example, you need to understand the basic physics of the molecule. For that, you need solid me...Oldest DNA ever recovered suggests earth was warmer than previously believed
... ... The results of the research were published today in the journal Scien...... Ten percent o...NIEHS researchers identify enzyme critical in DNA replication
... ... The re...CU researchers solve mystery of how DNA strands separate
Cornell researchers have answered a fundamental question about how two strands of DNA, known as a double helix, separate to start a process called replication, in which genes copy themselves.... The research, published in the current issue of the journal Cell, examined the role of an enzyme called a helicase, which plays a major role in separating DNA strands so that replication of a single stra...New method for reading DNA sheds light on basis of cell identity
... A research team led by scientis...Discovery could help bring down price of DNA sequencing
... A million dollars for a map of all your genes is way out of reach for most people. The National Institutes of Health would like to bring it down to $1,000 by the year 2014, but plenty of technological hurdles remain before youll be able to secure your genetic blueprint for this more afforda...Critical protein prevents DNA damage from persisting through generations
... Early in the life of B lymphocytes -- the immune cells responsible fo...Scientists discover role of enzyme in DNA repair
... When DNA within a cell is damaged, the cells protective mechanism must do one of two things: repair the defect or commit suicide, says Rafael Casellas, Ph.D., an investigator in NIAMS Molecular I...TU Delft tracks the influence of a cancer inhibitor on a single DNA molecule
... The medicine inve...Researchers discover 'acquired' DNA key to certain bacterial infection
... ... The key to the bacteriums ability to enter environmental...Herpes virus hijacks DNA repair process
June 13, 2007 -- Scientists probing the details of viral infection have discovered an intriguing surprise: in mice, herpes viruses hijack their host cells' tools for fixing DNA damage and use those tools to enhance their own reproduction. ... The DNA damage response normally fixes DNA errors caused by radiation or other environmental factors, or mistakes accidentally introduced when cells copy t...Nanotechnology meets biology and DNA finds its groove
... ... Now, however, scientists have developed a quick, inexpensive and efficient method to extract single...DNA gets new twist: Carnegie Mellon scientists develop unique 'DNA nanotags'
... "Our DNA nanotags offer unprecedented densities of fluorescent dyes and, thus, the potential for extremely bright fluorescent labels, s...Buildup of damaged DNA in cells drives aging
PITTSBURGH, Dec. 20 The accumulation of genetic damage in our cells is a major contributor to how we age, according to a study being published today in the journal Nature by an international group of researchers. The study found that mice completely lacking a critical gene for repairing damaged DNA grow old rapidly and have physical, genetic and hormonal profiles very similar to mice that grow...Hepatitis C therapy: Inhibiting newly discovered microDNA molecule
Last fall Dr. Peter Sarnow and a team of Stanford University scientists reported that the hepatitis C virus needs a specific microRNA, named miR-122, in order to replicate in cultured liver cells. When the scientists inactivated the microRNA, the amount of hepatitis C virus RNA was reduced by approximately 80 percent. The discovery was widely heralded for its potential to develop new antiviral...Ancient DNA traces the woolly mammoth's disappearance
... ... In combination with the results on other species, a picture...Crammed with charged DNA, pressure rises inside virus
... The virus, phi29, has a tiny motor that pumps its DNA into the capsidouter shellduring the assembly process. The potential energy of the tightly coiled DNA may help phi29 inject its genetic material into the bacterial cells it infects. Now a team led by physicists at the University of California, San Diego has used laser tweezers to measure the...Cigarette smoke alters DNA in sperm, genetic damage could pass to offspring
... ... Here we are looking at male germline mutations, which are mutations in the DNA of sperm. I...454 Life Sciences and Baylor College of Medicine complete sequencing of DNA pioneer
... When we began the Human Genome Project, we anticipated it would take 15 years to sequence...Analysis reveals extent of DNA repair army
Cells have the remarkable ability to keep track of their genetic contents and -- when things go wrong to step in and repair the damage before cancer or another life-threatening condition develops.... But precisely how cells monitor the integrity of their genomes, identify problems, and intervene to repair broken or miscoded DNA has been one of nature's closely held secrets. Now, however, a rep...DNA clues to inform conservation in Africa
... ... The study, one of the first of its kind, identified 28 key regions for bushbucks. By understanding the genetic similarity of populations inhabiting different h...Repair of DNA by Brca2 gene prevents medulloblastoma
... The St. Jude researchers demonstrated that the Brca2 gene plays a dual role in the developing nervous system, eliminating errors in the DNA of newly made copies of chromosomes and suppressing the onset of the brain cancer medulloblastoma. Medulloblastoma is a cancer of the cerebellumthe lower back part of the brain that cont...Effect on breast tumors of DNA alternations in 3 genes described
BUFFALO, N.Y. -- Cancer epidemiologists at the University at Buffalo have identified specific genes that are most likely to become cancer promoters when exposed to a process called DNA promoter hypermethylation.... Hypermethylation is a process that causes genes that promote normal cell growth to produce proteins that cause malignant behavior, or unregulated cell growth. Until now, data has be...DNA analysis suggests under-reported kills of threatened whales
... The study, involving numerous researchers led by Scott Baker of Oregon State University, was just published in the journal Molecular Ecology. Baker, who is associate director of OSU's Marine Mammal Institute, also is presenting his findings to the International Whaling Commissi...DNA-damage test could aid drug development
... Like the current FDA-approved test, the new test looks for...DNA sieve -- Nanoscale pores can be tiny analysis labs
Imagine being able to rapidly identify tiny biological molecules such as DNA and toxins using less than a drop of salt water in a system that can fit on a microchip. It's closer than you might believe, say a team of researchers at the National Institute of Standards and Technology (NIST), Brazil's Universidade Federal de Pernambuco, and Wright State University in Dayton, Ohio.... ...In a paper a...Baumann Lab defines proteins that distinguish chromosome ends from DNA double-strand breaks
... ... "Surprisingly, we found that neit...Study finds regions of DNA that appear linked to autistic spectrum disorders
... Autism a disorder that involves social deficits, language problems and repetitive, stereotyped behaviors affects around one in 1,000 children. And the combined incidence of autism spectrum disorders, which include Asperger syndrome and pe...