Most promising clinical uses for stem cells from fat agreed on by international society
... of the meeting was the development of a consensus defining key scientific questions for future study and determining the field's most promising clinical applications. More than 300,000 liposuction procedures are performed in the United States each year, producing about 150,000 gallons of fat that is norma...Single genetic defect links many risk factors for heart disease and stroke
...entified by Shulman. Lifton has no illusions that defining the mechanisms underlying such linkages will be easy. "We have identified this defect and linked it with these traits, but there remains a complex black box in between," he said. "We don't know the mechanism that links the two." A better understandi...New method studies living bacterial cells
... new capabilities set the stage for future studies defining mineral-metal-microbe interactions in contaminated environments. "This technique also should be directly applicable to investigations of microbial processes in extreme subsurface environments and to studies of a variety of astrobiology topics, such ...Wistar study demonstrates heritability of non-genomic information
PHILADELPHIA It's one of the defining tenets of modern biology: The characteristics of a living organism are coded into the organism's DNA, and only information in the DNA can be passed to the organism's offspring. A new study by scientists at The Wistar Institute, however, suggests that...Gut microbes can open gates in fat cells
...ipulate networks of human genes," Gordon says. "By defining these networks, we can learn 'new ways' to promote health." As a result of such research, physicians may one day opt to make specific changes in the mixture of a person's gut microorganisms to improve heath or use the natural products that gut micro...Scientists advocate genomic sequencing of 'living fossil'
...trapods. Fleshy, lobed fins, which are one of the defining characteristics of coelacanths, are thought to represent an intermediate evolutionary stage in the transformation of fins to limbs. Lobe-finned relatives of the coelacanth underwent morphological alterations that enabled them to emerge from the sea ...New findings may redirect strategies for treatment of prostate cancer
... hormone-refractory prostate cancer. "By precisely defining the kinases and phosphorylation sites on AR and/or AR-associated proteins regulated by this HER2 signal, we envision developing reagents that may identify the subset of patients most likely to benefit from anti-HER2 therapy," explains Dr. Sawyers. ...A global view of gene expression in the aging kidney
... strokes of a complex physiological process before defining its mechanisms. "A powerful, top-down, holistic approach," he wrote, "is to identify all of the components of a particular cellular process, so that one can define the global picture first and then use it as a framework to understand how the individu...INEEL honors five scientists as Laboratory Fellows
...actor Modular High Temperature Gas Reactor Project defining radiological source term for the environmental impact statement, developing the irradiation and accident performance testing needed to qualify the fuel and tritium targets. Since 1992, he has been the group leader of the Fusion Safety P...Scientists identify molecular events that drive cell senescence
...characteristic of senescence. We are interested in defining the molecular events leading to these changes in chromatin structure in senescent cells," explains study leader Dr. Peter D. Adams from the Fox Chase Cancer Center in Philadelphia. Dr. Adams and colleagues found that the histone macroH2A is specifica...Urban ecology study witnessing the birth of a 'designer ecosystem'
...cs of how these organisms interact. "We have been defining the Phoenix urban ecosystem, which, it turns out, functions very much like an ecosystem with bugs and birds and plants -- but in different sets of relationships, with much different abundances," said Redman. "The abundance of organisms is higher over...Scientists discover key genetic factor in determining HIV/AIDS risk
... this study further emphasizes the significance of defining all existing types of genetic variation and the impact that these variations may have on human susceptibility to infectious diseases." The study is the result of collaboration between NIAID-supported researchers and investigators from the U.S. Mili...FDA approves ABRAXANE(TM) for metastatic breast cancer
...nnovative treatment option, and this approval is a defining moment for APP. We applaud the tireless efforts of the ABRAXANE team at ABI and APP, the clinical investigators, and the patient participants in the trial who helped bring ABRAXANE to market and make it available to treat women who are often faced w...Biodiversity hotspots identify conservation priorities
... underscores the value of the hotspots concept for defining urgent conservation priorities," said Russell A. Mittermeier, president of Conservation International (CI) and co-editor of the new book. "We must now act decisively to avoid losing these irreplaceable storehouses of Earth's life forms." Nearly 400 s...Studies reveal methods viruses use to sidestep immune system
...n of its own to counteract our defenses." Further defining how RNA viruses target and control host immune def...tified RIG-I, now we can spend our time completely defining the signaling pathway that goes from RIG-I all the way down to IRF-3," Dr. Gale said. "Once we've do...Anita Roberts to deliver Excellence in Science lecture
...GF- has emerged as the paradigmatic growth factor, defining the cell- and context-specific actions now attributed to many growth factors. TGF-1 was the first of what is now known to be a large family of over 40 structurally related growth factors. TGF- is involved in wound healing and in the pathogenesis of ...Study examines role of EGFR gene mutations in lung cancer development
...dence of somatic mutations complicates the task of defining the cancer genome, these differences provide unique opportunities to discover the predisposition factors linked to the development of cancer."...Scientists discover that three overlapping signals in embryo help get the backbone right
... eventually dies. "Gastrulation and the process of defining your back-belly axis is such an important step that you actually have multiple proteins being expressed there, just in case one of them fails, the others can compensate," said lead author Mustafa Khokha (pronounced KO' ka), a post-doctoral fellow at ......h Institute is moving into a comprehensive program defining variations of all the genes in the genome," he said. That means looking at both normal subjects and patients with diseases. "Papers like this one define the starting gate," said Scherer. "Now the research community is taking the next step. We are in...Highly adaptable genome in gut bacterium key to intestinal health
...eracts with other members of the gut ecosystem. By defining the factors that underlie the stability of the gut ecosystem, they may be able to develop ways to manipulate the gut's bacterial community to promote health or treat diseases. For example, the group is assessing how the bacterial capacity for process...