Tag: "endocytosis" at biology news

Scientists explain how morphogens work

...e this hypothesis, Lin and colleagues blocked cell endocytosis and examined Dpp morphogen movement. They found that inhibiting endocytosis disrupts the cell's ability to transduce Dpp signaling, but does not block Dpp movement across cells...

Bound for destruction

...t first be internalized through a process known as endocytosis before they can be digested by the proteasome, and...ubiquitin ligase have been shown to operate in the endocytosis of ligand-activated Notch. The group first showed that an increase in nedd4 activity resulted in th...

Gene with broad role also causes prevalent, inherited nerve disorder

...dence that defects in microtubule organization and endocytosis might underlie the symptoms of intermediate CMT, further examination of the gene's effects will be required given its broad variety of cellular functions, Vance said. Further work is also required to discern the role of dynamin 2 in the development o...

Structure-building cell signals also may influence learning, memory

... eliminate these materials. Synaptojanin-1 enables endocytosis when it disassembles a molecular coating on storag...hers then looked at whether ephrin truly increased endocytosis in cells that were not altered genetically. Using rat brain cells, they found that increased signali...

UQ researcher journeys to the centre of the cell

...venues to stop some viral infections. In addition, endocytosis can be used by researchers aiming to deliver drugs into cells," he said. "This new pathway was long suspected, however our work was the first to conclusively prove its existence and to identify the cellular structures involved. "The discovery of th...

Researchers develop assay that could be applied to drug screening

...tes for cargo internalization is clathrin mediated endocytosis (CME). CME is of fundamental importance for many c...ds. "Although the basic model of clathrin-mediated endocytosis was proposed 41years ago, there are many basic questions outstanding," Zenisek said. "For instance, ...

Researcher uncovers details of how cancer spreads

...ells and normal cells regarding a mechanism called endocytosis -- which cells employ to let materials enter through the cell membrane. The researchers used a protein called v-Src derived from an oncogenic virus, which has the ability to transform a normal cell into one with many features resembling those found ...

Hide and seek: Researchers discover a new way for infectious bacteria to enter cells

...g a structure called a vesicle. "Phagocytosis and endocytosis may, in fact, be more similar than past research s...rticle scientists believed a cell could take in by endocytosis could invade non-phagocytic cells. Other labs had made similar observations with other bacteria. Co...

A new step towards an AIDS vaccine

... Initially, envelope-CD4 interactions mediate the endocytosis of HIV-1. Next, viral nucleic acids, particularly RNA, stimulate pDCs through Toll-like receptors. A decrease of blood pDC frequency is typically observed in chronic infections due to HIV-1 and correlates with high viral load, reduced CD4 counts an...

JCI table of contents November, 2005

... Initially, envelope-CD4 interactions mediate the endocytosis of HIV-1. Next, viral nucleic acids, particularly RNA, stimulate pDCs through Toll-like receptors. A decrease of blood pDC frequency is typically observed in chronic infections due to HIV-1 and correlates with high viral load, reduced CD4 counts an...

2005 EURYI Awards highlight the future excellence of science in Europe

...tems analysis of caveolae- and lipid raft-mediated endocytosis in multicellular physiology said, "It's nice recognition of my work so far. Professionally, it gives me freedom to focus on my research and not worry about the money. This is what we all want to do most." Swiss Award winner Patrick Meraldi agreed. "...

Novel nuclear function of clathrin

...a new unexpected research field that connects p53, endocytosis and tumorigenesis."...

Eleven million Euros for Endotrack

...the thus far largely unexplored connection between endocytosis and the signalling of growth factors into the cell... pathogens occurs via a cellular mechanism, called endocytosis (a process in which substances gain entry into cells without passing through the cell membrane). Dur...

News tips from the Journal of Neuroscience

... Alexander Sorkin Sorkin et al. set out to track endocytosis of the dopamine transporter (DAT) by creating a mutant transporter with a hemagglutinin (HA) epitope-tag in the large extracellular loop. The authors then followed uptake with an HA antibody in a so-called antibody feeding assay. Although DAT undergo...

JCI table of contents -- March 22, 2007

...y cells. TITLE: Intersectin links WNK kinases to endocytosis of ROMK1 AUTHOR CONTACT: Chou-Long Huang University of Texas Southwestern Medical Center, Dallas, Texas, USA. Phone: (214) 648-8627; Fax: (214) 648-2071; E-mail: chou-long.huang@utsouthwestern.edu . View the PDF of this article at: https://www...

News tips from the Journal of Neuroscience

...E/L vesicle mobilization. The authors propose that endocytosis is a control point for the massive requirement for membrane in myelin. 3. Flash Stimulation of the Circadian Visual System Luis Vidal and Lawrence P. Morin The mammalian ber-clock in the supra-chiasmatic nucleus (SCN) sets the circadian rhythm...

Asymmetry due to perfect balance

...f a cap is replenished through directed transport, endocytosis mainly leads to a sharpening of the cap edges. "We... that a balance of diffusion, active transport and endocytosis is enough to describe the process of cortical polarity with exceptionally high accuracy. "Our model ...

Study revises dynamin's role in nerve cell function

...f a family of enzymes involved in synaptic vesicle endocytosis -- a reverse of the process of transmission of cel... our outlook on dynamin 1, and on synaptic vesicle endocytosis in general," Dr. Ryan says. "It's an exciting new discovery, one that we didn't expect. But all good...

Iowa State scientists demonstrate first use of nanotechnology to enter plant cells

...es can enter animal cells through a process called endocytosis the cell swallows or engulfs a molecule that is outside of it. The biologists attempted to mimic that process by removing the wall of the plant cell (called making protoplasts), forcing it to behave like an animal cell and swallow the nanoparticle....

Systems characterization of cell surface receptors

... Receptors display a wide range of state-dependent endocytosis rates, but the functional significance of these pa...s for network function and robustness to show that endocytosis and other receptor/ligand properties can be described by just a few control parameters. Using mathem...

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