Huntington's disease study shows animal models on target
...... ... ....Drug protects brain cells in Huntington's disease model, researchers find
... ... The drug can actually prevent brain cells from dying, said Dr. Ilya Bezprozvanny, associate professor of physiology at UT Southwestern. Its...Better sleep may put Huntington's disease sufferers back on track
... ... According to the Cambridge neuroscientists conducting the research, HD mice have abnormal circadian rhythms; t...Hunting down the causes of Huntington disease
Huntington disease (HD) is a degenerative brain disease in which brain cells called neurons die as a result of aggregations of the polyQ-huntingtin protein. Symptoms include involuntary movements, personality changes, and dementia, and unfortunately, there is no effective treatment to delay or prevent HD. In a study appearing April 6 in advance of print publication in the May issue of the Jour...Subtle signs can help predict Huntington's disease early
... "These results will help us understand how and who will develop Huntington's, which is important information as potential treatments are developed," said study author Jane...Protein interactions targets for Huntington disease therapy
... BCM scientists actually determined which proteins among the list of more than 200 identified at Buck Institute modify the effect of the Huntingtons protein. The Buck Institute is located in Novato, California.<...Landmark study identifies large number of new proteins implicated in Huntington's disease
Researchers from four organizations have identified more than 200 new proteins that bind to normal and mutant forms of the protein that causes Huntingtons disease (HD). HD is a fatal inherited disease that affects 30,000 Americans annually by laying waste to their nervous system. The research was led by Buck Institute faculty member Robert E. Hughes, PhD. Results of the study, which may facili...Study links faulty DNA repair to Huntington's disease onset
... ... The s...Proteasome activator enhances survival of Huntington's disease neuronal model cells
...To function, each living cell needs both to build new and to degrade old or damaged proteins. To accomplish that, a number of intracellular systems work in concert to keep the cell healthy and from clogging up with damaged proteins. When proteins or peptides mutate, they can present major problems to the clearing up of the intracellular environment. In Huntington's disease (HD) the disease pr...Test reveals effectiveness of potential Huntington's disease drugs
... "These drugs have been tested in a variety of Huntington's disease models and some HD human trials and results are very difficult to interpret," said Dr. Ilya Bezprozvanny, associate professor of physiology and senior author of the study, available online and published in...Metabolic disorder underlies Huntington's disease
... ... The findings may help to explain other symptoms of the dise...Unique Huntington's study moves forward
... An international team led by neurologist Ira Shoulson, M.D., of the University of Rochester Medical Center is trying to identify the earliest signs of the onset of the disease. The information will help clinicians design better studies of new drugs aimed at alleviating or postponing illness. It also helps researchers understand ho...Cure found for Huntington disease in mice offers hope for treatment in humans
VANCOUVER, B.C.: Researchers at the University of British Columbia's Centre for Molecular Medicine and Therapeutics (CMMT) have provided ground-breaking evidence for a cure for Huntington disease in a mouse offering hope that this disease can be relieved in humans....... Published today in Cell journal, Dr. Michael Hayden and colleagues discovered that by preventing the cleavage of the mutant hu...Gene therapy injected into the brains' of mice with Huntington's disease
Researchers at Rush University Medical Center, Chicago, and Ceregene Inc., San Diego, have successfully used gene therapy to preserve motor function and stop the anatomic, cellular changes that occur in the brains of mice with Huntington's disease (HD). This is the first study to demonstrate that, using this delivery method, symptom onset might be prevented in HD mice with this treatment. .........Research suggests cause of neurodegeneration in Huntington's disease
ATLANTA - The severe neurodegeneration associated with Huntingtons disease may result from molecular mutations that block the transport of nutrients within cells. Findings from the Emory University School of Medicine indicate that the mutant huntingtin protein limits the efforts of the huntingtin-associated protein-1 (HAP1) to provide nutrients to growing neurons, or neurites. Without those nut...MIT research holds promise for Huntington's treatment
CAMBRIDGE, Mass.--Researchers at MIT and Harvard Medical School have identified a compound that interferes with the pathogenic effects of Huntington's disease, a discovery that could lead to development of a new treatment for the disease....... There is no cure for Huntington's, a neurodegenerative disorder that now afflicts 30,000 Americans, with another 150,000 at risk. The fatal disease, which...Combination of PET, MR imaging shows white matter degeneration in Huntington's disease patients
Using both brain function (PET) and anatomical structure (MR) imaging studies, Italian researchers--within the context of an Italian-British collaboration--discovered that degenerative and dysfunctional events occur in individuals many years before the onset of Huntington's disease--particularly in the brain's white matter--an area not previously considered primarily involved with the disease. In...Study points to molecular origin of neurodegenerative disorders, including Huntington's disease
CHAPEL HILL -- New research from the University of North Carolina at Chapel Hill School of Medicine points to the possible molecular origin of at least nine human diseases of nervous system degeneration.... ... The findings are currently in PLoS Computational Biology, an open-access journal published by the Public Library of Science (PloS) in partnership with the International Society for Computa...Old drug shows new promise for Huntington's Disease
Clioquinol, an antibiotic that was banned for internal use in the United States in 1971 but is still used in topical applications, appears to block the genetic action of Huntington's disease in mice and in cell culture, according to a study reported by San Francisco VA Medical Center (SFVAMC) researchers.... ...The study, led by principal investigator Stephen M. Massa, MD, PhD, a neurologist at S...Huntington's cure in flies lays groundwork for broader treatment approaches
MADISON-Boosting levels of two critical proteins that normally shut down during Huntington's disease, researchers at the University of Wisconsin-Madison and the Cold Spring Harbor Laboratory have cured fruit flies of the genetic, neurodegenerative condition.... ...Forms of the same proteins-known in short form as CREB and HSP-70--exist in all cells, including those of humans.... ...The study resu...Molecular trigger for Huntington's disease found
Researchers have discovered a key regulatory molecule whose overactivation by the abnormal protein produced in Huntington's disease (HD) causes the central pathologies of the disease. The abnormal HD protein activates the regulatory protein called p53, which in turn switches on a host of other genes. This abnormal gene activation damages the cells' power plants, called the mitochondria, and kills...New insights into how Huntington's disease attacks the brain
Scientific theory holds that Huntington's disease (HD) is caused by a mutant protein that arises within brain cells and kills them, triggering the genetic neurological disorder. Now a new UCLA Neuropsychiatric Institute study reveals the first strong evidence that the mutant protein also elicits toxic interactions from neighboring cells to provoke the fatal brain disorder. The May 5 edition of...New insight into Huntington's disease pathology
The symptoms of Huntington's disease (HD)--severe loss of muscle control, emotional disturbance, and cognitive decline--are not just due to the toxic effects on brain cells of the mutant protein that causes the disorder, researchers, led by X. William Yang at Neuropsychiatric Institute of David Geffen School of Medicine at UCLA, have found. Their studies with genetically altered mice have reveale...Researchers identify potential therapeutic target for Huntington's disease
Researchers studying yeast cells have identified a metabolic enzyme as a potential therapeutic target for treating Huntington's disease, a fatal inherited neurodegenerative disorder for which there is currently no effective treatment. The group, whose results appear in the May issue of Nature Genetics, includes researchers from the University of Washington School of Medicine in Seattle and the Un...U. Iowa researchers improve Huntington's disease symptoms in mice
Researchers at the University of Iowa Roy J. and Lucille A. Carver College of Medicine have taken another step toward a potential treatment for Huntington's disease (HD). Using an approach called RNA interference (RNAi), the scientists reduced levels of the disease-causing HD protein in mice and significantly improved the movement and neurological abnormalities normally associated with the diseas...University of South Florida designated Center of Excellence by Huntington's Disease Society
Tampa, FL (Nov. 18, 2004) -- The University of South Florida has been designated a regional Center of Excellence by the Huntington's Disease Society of America (HDSA). USF was one of four universities across the nation competitively awarded the prestigious designation this year, and is the only HDSA Center of Excellence in Florida.... ...The designation includes $50,000 a year in funding to he...Study using robotic microscope shows how mutant Huntington's protein affects neurons
Using a specially designed robotic microscope to study cultured cells, researchers have found evidence that abnormal protein clumps called inclusion bodies in neurons from people with Huntington's disease (HD) prevent cell death. The finding helps to resolve a longstanding debate about the role of these inclusion bodies in HD and other disorders and may help investigators find effective treatmen...Gladstone researchers resolve key Huntington's disease mystery in Nature cover story
A mystery long associated with Huntington's disease has been resolved by a team of researchers at the UCSF-affiliated Gladstone Institute of Neurological Disease, thanks to a specially designed microscope that allows researchers to track changes in cells, including those associated with neurodegeneration, over long lengths of time.... ...As reported in the cover story in the current issue of Natu...