Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
... samples and cell lines to identify mutations that impact NF-κB activation. Dr. Louis M. Staudt from the National Cancer Institute led a research group who revealed the importance of both the classical and alternative NF-κB pathways in MM pathogenesis. Most MM patient samples examined exhibited ...New, more direct pathways from outside the cell-to-cell nuclei discovered
...tion," and predicts that it "will have an enormous impact on how scientists think about how cellular functions are regulated." Gavin has only observed direct pathways from the extracellular environment to the nucleus in the one-celled protozoan Tetrahymena thermophila. But Gavin says that "other discoveri...No evidence that widely prescribed statins protect against prostate cancer
... that statins may not have a clinically meaningful impact on testosterone in the blood, although further stu... might be a more realistic representation of their impact on the body, compared to outcomes seen in a clinical trial. Halls team studied the medical histor...deCODE discovers cause of major subtype of glaucoma
...on glaucoma, meaning that if we can neutralize the impact of these variants we might eliminate the disease. The LOXL1 protein made by this gene appears to play a role in the accumulation of microfibullar deposits that causes XFG, providing a promising mechanism to target for developing therapy. We plan to c...Gilbert Foundation and American Fed for Aging Research award grants on Alzheimer's disease
... aging, genetics, biomarkers, inflammation and the impact of exercise and the environment. Award recipients include: Yaniv Assaf, Ph.D., Lecturer, Tel Aviv University: "Hippocampus characterization of mice over-expressing APP and APOE3/4 using multi-dimensional MRI" Dr. Assaf will study the role ...1 of deep ocean's most turbulent areas has big impact on climate
...el rise, weather patterns such as El Nino, and the impact of these events on fisheries. St. Laurent compared the flow of seawater through underwater gullies in the Mid-Atlantic Ridge to the wind, so familiar to hikers, that blows through mountain passages on land. That wind creates a condition known a...European Science Foundation's Forward Look reaches out beyond the endless frontiers
... are subjected to proper external peer review. The impact of such an approach is evident in the reception of...ompletion of the Forward Look there have been high impact follow up actions: Inclusion of the ESF Forward Look results in the EC Strategic Research Agenda ...Carnegie Mellon's Peter Adams receives EPA research grant
... global climate change and international pollution impact U.S. air quality. Spyros Pandis, a chemical engineering research professor, is a co-investigator on the grant. Adams, an associate professor of civil and environmental engineering at Carnegie Mellon, said he will build integrated models over the nex...Female gender provides an advantage in renal diseases
...sue as well as affect various growth factors which impact the kidney. Research Update: Estrogen in Renal Disease Previous studies using animal models have used hormonal manipulation to explore the effects of sex hormones on renal disease. In these studies, researchers either added supplemental levels...Experiment suggests limitations to carbon dioxide 'tree banking'
...eed to fertilize vast areas," Oren added. "And the impact on water quality of fertilizing large areas will be intolerable to society. Water is already a scarce resource. " In a presentation delivered on Tuesday, Aug. 7 by Heather McCarthy, Oren's former graduate student, eight scientists working at the FA...High-intensity ultrasound may launch attack on cancer, wherever it lurks
...the tumor cells, may have an even more significant impact in suppressing cancer metastasis by waking up the immune system. For reasons that are still not completely understood, cancer cells often go largely undetected by the immune system, Zhong said. For an anti-tumor immune response to be effective, it ...Role of thyroid hormones in slumber under investigation at Rutgers
...ing to learn the true extent of how these hormones impact our overall health, Martin says. The research underway at Rutgers-Camden will build on earlier findings by providing specific measurements of the levels of thyroid hormones and the compounds which are derived from them in the brain during circadia...Study: Sticking to the sand might not be such good, clean fun for beachgoers
...ecal indicator bacteria to coastal waters-and will impact beach closures and advisories." Since 1990, the number of beach closures and health advisories throughout the United States has increased steadily, according to the NRDC. In 2005, the council tallied more than 20,000 days of closures and advisories...... consequences. No human activity has so large an impact on water systems as does agriculture, according to Johan Rockstrom (Stockholm Environment Institute, Sweden). He notes that the future will bring an even greater demand on fresh water for food productionby 2050 global water use for food production ...Genetic factors strongly shape how peers are chosen
...the first time the degree to which genetic factors impact how people choose their social environment. Fro...esearchers found that genetic factors increasingly impact how male twins make choices as they mature and develop their own social groups. The road from gene...Biologist traces coconut's history through DNA
...; the geographical origin(s) of domestication; the impact of human activities in homogenizing population structure across the species range; and the possible geographical location of the undomesticated wild progenitor populations....Space-borne sensors help Africa tackle water shortage problems
... show how demographic variables and pressures will impact natural resources," Nkhoma said. The project focused on the Kafue River Basin, which is a sub-basin of the Zambezi River. The Kafue Basin is of great importance to the countrys economy and is home to more than half of the countrys population. "...National Ecological Observatory Network featured at ESA/SER Joint International Conference
...changes in climate, land use, and invasive species impact ecology. NEON will serve as a national laboratory to gather long-term data on ecological responses of the biosphere to changes in land use and climate, and on feedbacks with the geosphere, hydrosphere, and atmosphere. NEON is the first initiative i...New survey documents the headaches of computerized medicine
...70 percent of the institutions ranked the level of impact on operations as moderately to very important. Those were issues involving alterations in workloads, workflow, communication patterns, never ending system demands, emotions and system overdependence that led to havoc during system failures. Doctors, ...Identified mechanism in the malaria parasite to help it adapt to infected individuals
...athogens, the scientific journal with the greatest impact on the field of Parasitology. 30 genes are know to be involved in the process of invasion. Now, the scientists have found that P. falciparum can activate and deactivate the expression of 7 of these genes (and their corresponding proteins) without...