Other highlights in the Aug. 7 JNCI
... ... ... Chen-Xu Qu, M.D., and colleagues conducted a randomized clinical trial that examined whether four vitamin-mineral supplement combinations could effect the liver cancer death r...Other highlights in the July 24 JNCI
... ... Breast cancer incidence has been on the rise since the late 1930s, but a recent report showed the first statistically significant decline in breast cancer incidence in 2003. Over this period, rates of hor...Other highlights from the July 10 JNCI
... ... ... Natalya Rapoport, Ph.D., D.Sc., of the University of Utah in Salt Lake City and colleagues describe a new method of drug delivery that may add...Other highlights in JNCI, June 26
... ... ... Carol Moinpour, Ph.D., of the Fred Hutchison Cancer Research Center in Seattle and colleagues investigated sexual dysfunction in more than 17,000 men w...Other highlights in JNCI, June 12
AIDS-Related Cancers Decline with Introduction of Intense...Antiretroviral Therapy ... ... AIDS patients are at high risk for Kaposi sarcoma, non-Hodgkin lymphoma, and cervical cancer, but recent studies have found the incidence of Kaposi sarcoma and non-Hodgkin lymphoma has been declining in people with AIDS since the introduction of HAART in 1996. This therapy usually increases the number of...Other highlights from the June 6 JNCI
... ... ... Aditya Bardia, M.D., of the Mayo Clinic in Rochester, Minn., and colleagues analyzed data from the Iowa Womens Health Study on aspirin and nonas...Other highlights in the May 16 JNCI
... ... ... ... In both men and women, drinking at least one al...Other highlights from the March 21 JNCI
... ... ... Anne Thibaut, Ph.D., of the National Cancer Institute in Bethesda, Md., and colleagues asked 188,736 postmenopausal women how much and how often they ate certain foods to determine...Other highlights in the March 7 JNCI
... ... High breast density is a strong predictor of breast cancer risk, but researchers did not know whether changes in breast density over time would affect this risk. Karla Kerlikowske, M.D., of the University of California, San Francisco, and colleagues loo...Other highlights in the Feb. 21 JNCI
... ... ... Kristina Lagerstedt Robinson, Ph.D., of the Karolinska University Hospital in Stockholm, and her colleagues selected a group o...Other highlights in the Jan. 17 JNCI
... ... In the Calcium Polyp Prevention Study, 930 people with a recent adenoma were randomly assigned to receive 4 years of daily 1200-milligram calcium supplements or a plac...Other highlights in the January 3 JNCI
...Regular use of cholesterol-lowering drugs called statins is not associated with a reduced risk of colorectal cancer, according to a population-based case-control study. ... Laboratory tests of statins have found anticancer effects on colon cancer cells. One case-control study of people found that use of statins for at least 5 years reduced the risk of colorectal cancer by 50 percent. To furt...Other highlights in the December 20 JNCI
... ... In the last several years, researchers have discovered a small population of so-called cancer-initiating cells (also called cancer stem cells) in several cancers. These cells can self-renew and maintain the growth of a tumor, whereas its daughter cells cannot. Scientists are studying the properties of cancer-initiating c...Other highlights in the November 15 JNCI
... ... ...<...Other highlights in the November 1 JNCI
... ... Statins and fibrates are often used for prevention of heart disease, and some research has suggested trial participants taking these medications have a lower melanoma incidence. Robert P. Dellavalle, M.D., Ph.D., of the Department of Veterans Affairs Medical Center in Denver, Colo., and colleagues reviewed 20 randomized controlled trials in which statins or fibrates were used as...Other highlights in the October 18 JNCI
... ... Calvin H.L. Law, M.D., F.R.C.S.C., of the University of Toronto, and colleagues identified 8,380 patients 18 years and older...Other highlights in the September 20 issue of JNCI
... ... Benjamin D. Smith, M.D., of the Yale School of Medicine in New Haven, Conn., and colleagues used the National Cancer Institute's Surveillance, Epidemiology, and End Results database to identify 3,409 women age 66 and over who had undergone conservative surgery for DCIS. They examined whether additional treatment with radiation therapy was associated with lower risks for sub...Other highlights in the September 6 JNCI
... ... Neuroblastoma, a tumor of the sympathetic nervous system, is the most common solid tumor in children outside the brain. When metastatic neuroblastomas have multiple copies of a gene called MYCN, they are classified as high-risk and aggressive. Metastatic neuroblastomas without multiple copies of the MYCN gene can be classified as aggressive based on the age...Other highlights in the August 16 JNCI
... ... ... The authors found that drinking...Other highlights in the August 2 issue of JNCI
... ... ... The authors found that 65.4% of the patients...Other highlights in the July 19 JNCI
... ... ... The authors found that the genetic patterns in urine DNA matc...Other highlights in the July 5 JNCI
... ... ... The authors identified 984 patients with colon cancer and 58...Other highlights in the June 21 JNCI
...... High levels of cadmium may be tied to an increased risk of breast cancer, according to a new study. However, whether increased cadmium actually causes breast cancer or whether cadmium levels increase in response to treatment or the disease itself remains unknown....... Cadmium is a long-lasting heavy metal that accumulates in the body. It is found in food and tobacco smoke and is thought...Other highlights in the June 7 JNCI
...... Overexpression of a gene called uPA delayed tumor progression and decreased tumors' ability to create new blood vessels and proliferate, according to a new study. ...... Jaime M. Merchan, M.D., Vikas Sukhatme, M.D., Ph.D., and colleagues inserted two genes tPA and uPA into mammary cancer cells. These genes encode for enzymes that activate plasminogen, an enzyme that helps break down bl...Other highlights in the May 17 JNCI
...... Postmenopausal women who use statins have the same risk of breast cancer as those who do not, according to a new study....... Using a group of 156,351 women from the Women's Health Initiative study, Jane A. Cauley, Dr.P.H., from the University of Pittsburgh, and colleagues examined use of cholesterol-lowering drugs called statins and risk of invasive breast cancer. After an average foll...Other highlights in the May 3 JNCI
...... A new study says that researchers have not improved reporting of randomized controlled trials, despite guidelines developed 10 years ago. Papers published both before and after guidelines set out by the CONSORT (Consolidated Standards for Reporting Trials) statement, created in 1996, were missing major items needed for readers to evaluate the study. ...... Thilo Kober, Ph.D., of the Coch...Other highlights in the April 19 JNCI
...... BRCA1 and BRCA2 genetic mutation carriers older than 40 years display a similar reduction in breast cancer risk with increasing number of pregnancies carried to full-term, a risk parallel to that in the general population, according to a new study....... BRCA1 and BRCA2 mutations are known to increase a women's risk of breast cancer. In women without the mutations, reproductive factors su...Other highlights in the April 5 JNCI
...... A new study has identified 254 gene sequences whose expression in people with melanoma may be associated with developing metastasis. ... The underlying molecular mechanisms involved in the clinical progression of melanoma are not well known. Alain Spatz, M.D., of the Gustave-Roussy Institute in Villejuif Cedex, France, and colleagues examined gene expression in melanomas from 58 patients...Other highlights in the March 15 JNCI
...... High dietary folate intake may be associated with a reduced risk of pancreatic cancer, a new study suggests. However, supplemental folate intake was not associated with pancreatic cancer risk....... Susanna C. Larsson, M.Sc., of the Karolinska Institute in Stockholm, Sweden, and colleagues gave a food and diet questionnaire to 81,922 cancer-free men and women enrolled in the Swedish Mammo...Other highlights in the February 15 JNCI
... ...Parallel administration of chemotherapy and an anti-anemia drug called darbepoetin alfa every 3 weeks is safe and effective, according to a new study. ... ...Chemotherapy can reduce the bone marrow's ability to produce red blood cells leading to anemia. Anemia is a common side effect among cancer patients receiving chemotherapy. There are drugs available that are often given in conjunctio...Other highlights in the February 1 JNCI
... ...A new study suggests that the protein STAT1, which negatively regulates cell growth and survival, can suppress tumor growth in squamous cell carcinoma of the head and neck (SCCHN) tumors. When the promoter region of the STAT1 gene is chemically modified by a process called promoter hypermethylation, thereby inhibiting STAT1 expression, the result can increase SCCHN tumor growth. ... ...Re...Other highlights in the January 18 JNCI
... Women infected with HIV types 1 and 2 may have a higher risk of HSIL than HIV-negative women, according to a new study in Senegalese women....... Stephen E. Hawes, Ph.D., of the University of Washington in Seattle, and colleagues studied a cohort of 627 women with and without HIV types 1 and/or 2 and/or high-risk human papillomavirus (HPV) infection in Senegal, West Africa. They followed th...Other highlights in the January 4 JNCI
... A new study has found that a cancer drug and an engineered form of the herpes simplex virus may work together more effectively than either agent alone to destroy glioblastoma cells from human brain cancers....... The drug temozolomide, which stops tumor growth by preventing DNA replication in the cell, was approved in 2005 for the treatment of glioblastoma, a rapidly fatal type of brain canc...Other highlights in the December 7 JNCI
... A new study in mice has found that chronic stress may increase susceptibility to a type of skin cancer that is induced by ultraviolet (UV) radiation by suppressing T cells and certain molecules that support immune function.... ...Both chronic stress and exposure to UV radiation suppress the immune system, but the mechanism by which suppression occurs is not fully understood. A group of scie...Other highlights in the November 16 JNCI
... ...Increased physical activity is associated with decreased breast cancer risk in both black women and white women, a new study has found.... ...Dozens of studies have examined the association between recreational physical activity and breast cancer. However, questions remain about whether a reduction in risk is observed in all population subgroups. To examine the association between physica...Other highlights in the November 2 JNCI
... ...Alcohol consumption is associated with an increased risk of estrogen receptor (ER)-positive, but not ER-negative, breast cancer in postmenopausal women, according to a new study.... ...Many epidemiologic studies have found an association between alcohol consumption and breast cancer risk, but it has not been known whether this risk varies by hormone receptor type. Alicja Wolk, Dr.Med.Sc.,...Other highlights in the October 19 JNCI
... ...A new study has found that a treatment regimen that combines the monoclonal antibody C225 (cetuximab, Erbitux) and a method called photodynamic therapy (PDT) is synergistic and well-tolerated in a mouse model of ovarian cancer.... ...Because the prognosis for women diagnosed with ovarian cancer is poor--less than a third will survive 5 or more years--new treatment strategies are needed. C...Other highlights in the September 21 JNCI
...... Men who survive testicular cancer have an increased risk of developing a second cancer for at least 35 years after diagnosis, according to the largest study to date of testicular cancer survivors....... Testicular cancer largely affects young men, and the 10-year survival rate of the disease is as high as 95%, so most men survive testicular cancer. However, these men have an increased ris......... Knowing the status of the progesterone receptor (PR) in women with estrogen receptor (ER)-positive breast tumors may have important clinical relevance, including how these tumors respond to tamoxifen, according to a new study....... Many breast cancer therapies have been developed for women whose tumors overexpress ER (i.e., ER-positive tumors). However, data suggest that tumors that are......... Whether breast cancer is detected during screening mammograms or detected in other ways may help define a woman's prognosis, according to a new study....... Screening mammography detects breast cancers at an earlier stage of development than breast cancers detected symptomatically--the so-called stage shift--and so mammographically detected breast cancers tend to have better prognoses. Th...