St. Jude study solves mystery of mammalian ears
... The finding could explain why dogs, cats, humans and other mammals have such sensitive hearing and the ability to discriminate among frequencies. The work also highlights the importance of basic hearing research in studies into the causes of deafness. A report on this work appears in the advanced online issue of...Tiny tweezers and yeast help St. Jude show how cancer drug works
... Using a type of nanotechnology called magnetic tweezers as well as yeast cells, investigators showed that a camptothecin drug called topotecan kills cancer cells by preventing an enzyme, called DNA topoisomerase I, from uncoiling double-stranded DNA in those cells. Instead, the DNA becomes...St. Jude study shows genes play an unexpected role in their own activation
... The on switch, a protein called CREB, is a transcription factora molecule that binds to a section of DNA near a gene and triggers that gene to make the specific protein for which it codes. CREB activates genes in response to a molecule called cAMP, which acts as a messenger for a variety of stimuli including hormones and nerve-signaling molecules ca...St. Jude shows gene test not needed if cancer drug given in low doses
... The finding means that clinicians can begin treatment sooner and eliminate the cost of this specialized test, which...St. Jude study yields secrets of chromosome movement
... St. Jude researchers made their discovery by tracking the activity of...St. Jude named a Center of Excellence in flu research
... NIAID will award $23 million per year for seven years to establish the consortium of centers, which includes St. Jude, according to Robert Webster, Ph.D., a member of the Infectious Diseases department and holder of the Rose Marie Thomas Chair at St. Jude. Webster, the principal investigator for the NIAID contract at St. Jude, als...St. Jude named 'Research Leader' by Scientific American magazine
St. Jude Children's Research Hospital has been named by Scientific American magazine as a "Research Leader" within the 2004 Scientific American 50--the magazine's prestigious annual list recognizing outstanding acts of leadership in science and technology from the past year.... Richard Webby, Ph.D., of St. Jude Virology, was recognized as a leader in the Public Health and Epidemiology category f...