JCI table of contents: Aug. 9, 2007
... region of the brain known as the hypothalamus are lean because they eat less and move around more than normal mice. These effects on behavior were associated with decreased signaling in the hypothalamus through a protein known as PPAR-alpha. Administration of a PPAR-alpha agonist into the hypothalamus in...Obesity found to be a risk factor for multiple myeloma
...LADELPHIA -- An obese person is more likely than a lean person to develop multiple myeloma, according to researchers from Brigham and Womens Hospital, Harvard Medical School, and Harvard School of Public Health. Their findings indicate that Body Mass Index (BMI) a statistical measure that scales weight ...Insulin sensitizer also serves as energy-conserving signal to the brain
...n an effort to maintain adequate fat stores during lean times, the researchers report. Energy homeostasis may be mediated by both short-term regulators, such as gut hormones, and long-term regulators, said Takashi Kadowaki of the University of Tokyo. In this study, we identified, for the first time, a p...New blood test might offer early warning of deep belly fat
...ding abdominal organs, according to a new study of lean and obese individuals reported in the July issue o...n the visceral fat of viscerally obese relative to lean study participants, they found. By comparison, visceral fat RBP4 concentrations were increased just ...Fat fish put obesity on the hook
Everyone knows that eating lean fish helps slim waistlines, but researchers from the Center for the Study of Weight Regulation and Associated Disorders at Oregon Health and Science University in Portland, OR, have found a new way fish can help eliminate obesity. In a study to be pu...Dietary vitamin B6, B12 and folate, may decrease pancreatic cancer risk among lean people
...might protect against pancreatic cancer found that lean individuals who got most of these nutrients from food were protected against developing cancer. The study also suggests this protective effect does not hold true if the nutrients come from vitamin supplements. In a study published in the June 1 is...JCI table of contents: May 24, 2007
...development of insulin resistance in the livers of lean mice fed a normal diet, as well as impaired insulin signaling in fatty tissue, liver, and muscle. The authors went on to show that insulin resistance was even further impaired in these animals when they were fed a high-fat diet and the animals were o......emain permanently slim. 'Like those people who are lean by nature even though they overeat ? like we all d...ity. Animals born of leptin-treated mothers remain lean even when fed a fat-laden diet, while those from untreated dams gained weight and developed diabetes...Pimp my meatballs -- collagen injections safeguard nutrients
...rates into energy. It is found in many foods, like lean meats, but especially pork. Insufficient amounts of thiamine can lead to nerve damage, weakness, fatigue and psychosis. A lack of iodine in a diet can lead to iodine deficiency disorders (IDD), such as goiter or impeded mental development, which ar...JCI table of contents -- April 5, 2007
...ice lacking inhibitory leptin receptor signals are lean with normal endocrine function AUTHOR CONTACT: Martin G. Myers Jr. University of Michigan Medical School, Ann Arbor, Michigan, USA. Phone: (734) 647-9515; Fax: (734) 936-6684; E-mail: mgmyers@umich.edu . View the PDF of this article at: https:/...Insulin -- in need of some restraint?
...tin 2-deficient mice had less body fat and greater lean body mass. Vale, Lee and their collaborators are now piecing together a global view of how these urocortin peptides, which are members of the corticotropin-releasing factor family, and their receptors regulate responses to physical and even psychol...The metabolic response to colitis varies depending upon whether inflammation is chronic or acute
...e mice had returned to normal eating patterns. The lean mass of the chronic mice was normalized to the lev...mmation) had decreased body weights, lower fat and lean mass, reduced intakes of food and water, and a tendency towards lower levels of activity and energy ...AAAS Panel -- Sustainable aquaculture critical to feed the world
...the public about increasing their consumption of a lean protein such as fish," said Dr. Steven Otwell, a University of Florida professor and member of National Academy of Sciences' Seafood Safety Committee. "To meet the growing demand for healthy seafood, we absolutely must embrace and expand aquaculture...Power-boosting signal in muscle declines with age
...wn that, in comparison to 20-year-old adults, even lean and healthy people in their seventies show a higher incidence of fat buildup in their muscle and livers and a deficiency in mitochondrial function, Shulman explained. These metabolic shifts have been implicated in the increased prevalence of insulin ...DOE JGI upgrades IMG/M -- the Metagenomics Data Management & Analysis System
...ture 443, 950-955, 26 October 2006), and obese and lean mouse gut (Nature 444, 1027-131, 21 December 2006). In addition, IMG/M includes three of the simulated metagenome data sets employed for benchmarking several assembly, gene prediction, and binning methods ( http://fames.jgi-psf.org/ ). IMG/M's re...Relative abundance of common microbes living in the gut may contribute to obesity
... present in gut microbial communities of obese and lean mice, and by observing the effects of transplantin...dy, they compared genetically obese mice and their lean littermates. The obese mice had 50 percent fewer Bacteroidetes and proportionately more Firmicutes. ...Poor athletic performance linked to vitamin deficiency
...nts needed to repair and maintain higher levels of lean tissue mass present in some athletes and individuals may all affect an individuals B-vitamin requirements, said Manore. "Many athletes, especially young athletes involved in highly competitive sports, do not realize the impact their diets have on the...How diet, obesity and even gum disease may affect immune system and cancer
...n of lean, overweight and obese mice. They created lean mice by slightly restricting their diets and watch...equate immune response to a vaccine. Neither the lean mice nor the moderately overweight mice showed similar immune system impairments in response to vacc...Study shows link between morbid obesity, low IQ in toddlers
...of their normal-weight siblings. Researchers chose lean siblings as a control group "because they share a ...several sets of fraternal twins where one twin was lean and the other morbidly obese, yet their parents reported that each ate the same amount of food. In o...Being obese and a couch potato may have a biological basis in the brain
...The study found that the brains of rats bred to be lean are more sensitive to a chemical produced in the b... movements. Compared to rats bred to be obese, the lean rats had a far greater expression of orexin receptors in the hypothalamus. "The greater expressio...