Tag: "missing" at biology news
Component of volcanic gas may have played a significant role in the origins of life on Earth
...cience, Leman, Ghadiri, and Orgel suggest that the missing
link is a chemical component of volcanic gas known as carbonyl sulfide. Carbonyl sulfide is present in volcanic gasses and deep sea vent emissions today, and since these geological phenomena were prominent features on the early Earth, it is reaso...
Technique for genetically modifying blood stem cells brings cure for blood diseases closer
...Cs) in which both genes for beta-globin are either missing
or mutated. In the absence of beta-globin, the other building block of Hb, alpha-globin, accumulates and eventually destroys the red blood cell. HSCs are parent cells in the bone marrow that give rise to blood cells. The St. Jude team ...
Mice thrive despite massive genetic makeover
...esulting in mice that did not survive, because the missing
sequences contained important genes and their deletion had severe consequences for the animal. The other authors of the study include Yiwen Zhu, Ingrid Plajzer-Frick, and Veena Afzal. ...
New DNA repair enzyme makes mistakes to save lives of cells
...n the sequence sometimes arise, such as a wrong or missing
base or one that is damaged. If a problem somehow ...o-step handiwork. First, it replaces the site of a missing
or chemically changed base by inserting a new base even if its choice from one of the four bases is...
Clues to improving TB treatment
...essed by another protein called EthR. When EthR is missing
or disabled in tuberculosis, the bacteria produce too much of the EthA enzyme, which increases their vulnerability to ETH's antimicrobial attack. With this in mind, Baulard and colleagues decided to closely examine the molecular structure of EthR...
Potential new oncogene may be missing link in cancer-causing chain
...such as breast cancer. "We believe LRP6 may be the missing
link, the long-sought component that turns up the activity of this signaling pathway," Bu says. To uncover LRP6's role in cancer, Bu's team took slow-growing cancer cells and altered the LRP6 gene so that it made more of the protein. They found that ...
Children's Hospital Boston geneticist awarded for research on muscular dystrophy
...f that regenerative capacity and use it to deliver missing
genes?" Using this approach, his lab has gotten 5 percent of mouse muscles to begin making dystrophin, Kunkel expects this to increase to 20 percent. Once the technique is fully refined, the next step would be clinical trials in humans. Another major...
A clear view of mycobacterial infection
...ns of a virulent strain of M. marinum and a strain missing
a genetic region called RD1 a region that is somehow involved in the virulence of the bacteria Ramakrishnan and colleagues have observed that RD1 is actually required for granuloma formation and even recruits more macrophages to granulomas. This mi...
Government development policies, not communities, main threat to forest conservation projects
...rm of lavishly funded short-term projects. What is missing
are the resources for low-level, continuous management activities. Meanwhile, since March, 2002, Peru has auctioned off almost 7.5 million hectares of forest in private logging concessions, in a system that excludes local communities and threatens t...
Plentiful fossils of dinosaur contemporary allow population study
...nts also note when bones were missing, "so all the missing
values are data. For instance, we can look at how many are missing
a tibia, how many are missing
a femur, how many are missing
both, and how many fossils have all or m...
Researchers discover transport molecule that allows boron into cells
...birth defects occur, including impaired growth and missing
or extra limbs. Many animals cannot survive in the complete absence of boron. On the other hand, like many vitamins and minerals, too much is as bad as not enough. High levels of boron are toxic. Dr. Muallem's group showed that human cells with N...
Powerful 'toolkit' developed for functional profiling of yeast genes
...h a collection of almost 6,000 yeast strains, each missing
a different gene, and allows researchers to identi...one copy of each gene, so there's no back-up for a missing
gene that leads to slow growth. Pan's mutant yeast are protected from collecting genetic impurit...
NYU team develops enhanced algorithm for detecting changes in cancer genomes
... Its application reveals several excess as well as missing
copies of DNA segments associated with various forms of cancer and ultimately, points to locations of both oncogenes and tumor suppressor genes. In addition, the algorithm can be used to account for the varied genomes present across human population....
Ancient fossil offers new clues to brown bears past
... southern bears we see today. "Its like finding a missing
piece of a puzzle, or even a proverbial missing
link," said Matheus. "Their ancestors must have been stuck south of the ice sheets at the peak of th...
Scientists advocate genomic sequencing of 'living fossil'
... www.genome.gov/12511858 ), Myers observed: "We're missing
an organism that could really shed light on the emergence of land vertebrates. We don't know what genomic changes accompanied the transition from water to land, and a coelacanth genome could help identify those events." The coelacanth is one of only...
Genome of ancient fish could reveal evolutionary mysteries, Stanford scientists say
... vast diversity, a sequence in land animals that's missing
in one of the fish species is not necessarily involved in land animal biology, according to James Noonan, PhD, who did the coelacanth work as a graduate student at Stanford with Myers, the Stanford W. Ascherman, MD, FACS Professor in Genetics. That g...
Study identifies molecular complex vital to creation of miRNAs
...mans. A swathe of DNA containing multiple genes is missing
in DiGeorge syndrome patients, and many are born with heart defects, immune deficiencies, and developmental and behavioral problems. Intriguingly, one in four also goes on to develop schizophrenia, a disorder for which causative genes have yet to be ...
Random gene activation helps ulcer bug escape immune system
...olved in the gene's activation. The second copy is missing
an essential portion of DNA, making it completely nonfunctional. "This suggested that the strain doesn't make BabA protein at all, making it equivalent in that regard to about one-third of all the other clinical isolates of H. pylori scientists have ...
Hold the stuffing: Low-glycemic diet may help keep weight off
...etabolism and turn on hunger cues to "make up" the missing
calories. The low-glycemic-load (low-GL) diet reduces carbohydrates that are rapidly digested and that raise blood sugar and insulin to high levels -- such as white bread, refined breakfast cereals, and concentrated sugars. Instead, it emphasizes car...
Computer analysis shows scientists could reconstruct the genome of the mammalian common ancestor
...we find a DNA sequence in the human genome that is missing
in the corresponding place in the mouse genome, we can't tell whether that DNA was inserted in the evolution of humans from the mammalian ancestor or deleted in the evolution of mice," he said. "If the ancestral genome is available, this ambiguity di...
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