Role of autophagy in tumorigenesis
In the June 1 issue of G&D, Dr. Eileen White and colleagues at Rutgers University/University of Medicine and Dentistry of New Jersey/Cancer Institute of New Jersey, report, for the first time, that the cellular self-digesting process of autophagy can protect genome integrity lending new insight into the seemingly contradictory roles of autophagy as both a cell survival and tumor suppressor path...The DNA damage response and tumorigenesis
In the January 1 issue of G&D, Dr. Gerardo Ferbeyre and colleagues at the University of Montreal report that the DNA damage response pathway is a necessary mediator of oncogene-induced senescence. Using RNAi and a cell culture model of oncogene-induced senescence, the researchers determined that the DNA damage signaling pathways links oncogene expression (either STAT5A, E2F1 or Ras) and cellular...Origen publishes in Nature a robust and versatile method for creating transgenic chickens
BURLINGAME, CA (June 7, 2006): Origen Therapeutics announced today that it has succeeded in developing a robust and versatile technology for genetically modifying chickens that, for the first time, puts avian transgenics on a par with transgenic mice. The company made the announcement in conjunction with the publication of an article this week by Origen scientists and a collaborator from the Univ...Detailed in an upcoming report in G&D, Dr. Miles Wilkinson and colleagues use a new tissue-specific RNAi approach they developed to identify a novel postnatal role for the Wilms' tumor 1 (WT1) tumor suppressor in spermatogenesis. In a powerful example of the utility of their in vivo RNAi technology, the authors knock-down expression of WT1 specifically in Sertoli nurse cells in vivo. In conjuncti...Two papers in the August 1 issue of Genes & Development explore the genetic interactions between two well-known tumor suppressor proteins, PTEN and TSC2. ...... Together, the studies shed new light on the long-standing question as to how the loss of either protein (which act in the same pathway to inhibit mTOR signaling and cell growth) can have such dramatically different effects on tumor physio...Bethesda, MD Scientists in Tokyo have discovered a new protein, named PICT-1, that is involved in regulating PTEN, the second most commonly mutated tumor suppressor in human tumors. This discovery suggests the possibility of a new tumorigenic pathway that is due to defects in a protein involved in stabilizing PTEN rather than defects in PTEN itself.... ...The research appears as the "Paper of...