Scientists identify 2 distinct Parkinson's networks
MANHASSET, NY The disease that causes tremors, rigidity and slowed movements in a million Americans also targets another brain network that regulates cognitive thought and the ability to carry out everyday tasks. David Eidelberg, MD, head of the Center for Neurosciences at The Feinstein Institute for Medical Research, and his colleagues measured and quantified this network of brain regions duri...Tracing Parkinson's lethal mechanism
... In both mice and human patients, the researchers have found evidence that neurons die because of a crippling of a particular protective enzyme that eliminates potentially damaging reactive oxygen species normally generated in the cells power plants,...Lancet study shows gene therapy for Parkinson's disease is safe and some patients benefit
MANHASSET, NY -- A novel gene therapy technique is safe and may be effective at staving off worsening symptoms of Parkinson's disease, according to the first scientific review of a dozen patients who have received the treatment over the last three years. The results were published in the latest issue of Lancet.... The patients, half of whom live on Long Island, are in advanced stages of the il...Gene therapy study shows safety and statistically significant improvement in Parkinson's disease
... The open label Phase 1 study, conducted in 12 patients with advanced Parkinsons disease demonstrated both a lack of adverse events related to the gene therapy procedure and statistically significant improvements from baseline in b...PINK1 protects from Parkinson's
... In a study published t...Parkinson's protein protects neurons from stress induced cell death
... Usually, Parkinsons disease occurs after the age of 50 and in Germany about 400,000 people are affected. It is characterized by a decline of neurons in the so-called Substantia Nigra, a structure in the midbrain that produces dopamine. The resulting deprivation of this messenger substance causes symptoms like muscular tremor at rest and restrict...UCLA researchers discover link between Parkinson's and narcolepsy
... Now a team of UCLA and Veterans Affairs researchers think they know why the two disorders share something in common: Parkinson's disease patients have severe damage to the same small group of neurons whose loss causes narcolepsy. The findings s...Alzheimer's, Parkinson's, type 2 diabetes similar at molecular level
... ... ...Nanotechnology offers hope for treating spinal cord injuries, diabetes and Parkinson's disease
... Dr. Samuel I. Stupp, director of the Institute of BioNanotechnology in Medicine at Northwestern University, is one of a new breed of scientists combining nanotechnology and biology to enable the body to heal itself -- and who are...New studies link the environment to Parkinson's disease
Sunnyvale, CA April 5, 2007 The Parkinson's Institute today announced that new findings concerning the role of environmental factors in the development of Parkinson's disease will be reported at Asilomar (Pacific Grove, CA) as part of the final meeting of the Collaborative Centers for Parkinson's Disease Environmental Research (CCPDER). This collaborative research effort, sponsored by the Nati...NIH announces phase III clinical trial of creatine for Parkinson's disease
... The double-blind, placebo-controlled, phase III study is one of the largest PD clinical tri...The Parkinson's Institute to conduct Phase III Clinical Trial of creatine for Parkinson's disease
... The double-blind, placebo-controlled, p...UC San Diego supercomputer simulations may pinpoint causes of Parkinson's, Alzheimer's diseases
... A study published in this weeks Federation of European Biochemical Societies (FEBS) Journal offers for the first time a model for the complex process of aggregation of a protein known as alpha-synuclein, which in turn leads to harmful ring-like or pore-like structures in human membranes, the kind of damage found in Parkinsons and Alzheimers patients.<...DNA nanoparticles hold promise in gene therapy for Parkinson's disease
... Yurek's project, titled "Nanoparticle Gene Therapy...Sentry enzyme blocks two paths to Parkinson's disease
... Parkinson's disease is a disease in which nerve cells in part of the brain called the substantia nigra die, resulting in the loss of dopamine, a nerve-signaling molecule that helps control muscle movement. The absence of dopamine from these cells, called do...New study to test statin-Parkinson's link
... Suggestions of a statin link are not new, but the results of a recent study linking low LDL cholesterol to Parkinson's provide the strongest evidence to date that it could be real, because statins work by reducing LDL cholesterol. The study by researchers at University of North Car...Successful one year gene therapy trial for Parkinson's disease announced by Neurologix
Fort Lee, NJ, (October 17, 2006) Neurologix, Inc. (OTCBB: NRGX), a biotech company engaged in the development of innovative gene therapies for disorders affecting the brain and central nervous system, announced today that it has successfully completed its landmark Phase I trial of gene therapy for Parkinson's Disease with statistically significant results. The data was presented at the 36th Ann...Rush and UCSF found gene therapy appeared to reduce symptoms of Parkinson's by 40 percent
Ceregene, Inc., announced today that CERE-120, a gene therapy product in development for the treatment of Parkinson's disease, was well tolerated and appeared to reduce symptoms by approximately 40% (p<0.001), as measured by the Unified Parkinson's Disease Rating Scale (UPDRS) motor "off" score, in an open-label Phase 1 study in 12 patients with advanced disease. Initial results of the study we...Researchers announce results of study on genetic variation in Parkinson's disease
... The study was led by researchers at the National Institute of Aging (NIA) and National Institute of Neurological Disorders...Pre-clinical study finds Parkinson's cell death blocked by stopping inflammatory factor
... ... "Our findings suggest that TNF-dependent inflammation may be part of the progressive fea...Variability in certain gene associated with increased risk of Parkinson's disease
... Parkinson disease is a common neurological condition associated with increased illness and shortened life expectancy. The origin of Parkinson disease remains elusive, but genetic factors may be important, according to background information in the article. One of the most promising leads in the genetics of Parkinson disease is the potential role of the alpha-synuclein (SNCA) gene. Studies h...New discovery about Parkinson's at the Montreal Neurological Institute
... ... By studying defects in the genes of pa...Neurologists developing first standardized measurement scale for dyskinesia in Parkinson's patients
... ... Goetz...Dopamine drug leads to new neurons and recovery of function in rat model of Parkinson's
... ... The study suggests that drugs that affect dopamine D3 receptors might trigg...A probable cause for Parkinson's?
... But the precise connection between oxidation and neurodegenerative...diseases has eluded researchers. Now, a study by the Department of...Energy's Pacific Northwest National Laboratory and UCLA's David Geffen...School of Medicine reveals that damage is linked to a natural byproduct...of oxidation called nitratio...Parkinson's disease mechanism discovered
Howard Hughes Medical Institute researchers have pinpointed defects in a critical cellular pathway that can lead to the death of dopamine-producing nerve cells and ultimately Parkinson's symptoms. Their studies have also identified a new way to rescue dying neurons in several animal models of Parkinson's disease.... According to the researchers, the findings offer a promising opportunity for deve...Researchers reverse Parkinson's symptoms in animal models
CAMBRIDGE, Mass. -- Statistics for neurological disorders are grim. More than a million Americans suffer from Parkinson's disease alone--a number that is expected to soar over the next few decades as the population ages. No current therapies alter the fundamental clinical course of the condition. ...... Now, scientists at Whitehead Institute, in collaboration with colleagues at several research c...Single copy of Parkinson's-risk gene mutation may lead to earlier symptom onset
Mutations in a gene already known to play a role in causing an inherited form of Parkinson disease may also influence the age at which symptoms of the neurological disorder appear. While inheriting two abnormal copies of the parkin gene previously had been associated with the development of early-onset Parkinson's, a new study from a multi-institutional team led by Massachusetts General Hospita...Gene mutation may influence age at onset of Parkinson's disease
The number of mutations in a gene previously found to be associated with early-onset Parkinson's disease may influence the age at which the condition develops; even individuals who carry just one mutated copy may be more susceptible to Parkinson's disease, according to a report in the June issue of Archives of Neurology, one of the JAMA/Archives journals.... ...Parkinson's disease affects about 1...Tuberculosis drug may cure Parkinson's-like illness
WEST LAFAYETTE, Ind. - Researchers have discovered that a drug used to treat tuberculosis apparently cures patients of a Parkinson's-like illness suffered by thousands of mineworkers, welders and others exposed to high levels of the metal manganese....... Manganese is used to produce steel alloys and as a coating on welding rods, among other industrial applications. It replaced lead decades ago a...Key stress protein linked to toxicities responsible for Parkinson's, Alzheimer's
La Jolla, CA Researchers at the Burnham Institute for Medical Research have discovered a mechanistic link between cellular stress caused by free radicals and accumulation of misfolded proteins that lead to nerve cell injury and death in neurodegenerative disorders such as Alzheimer's and Parkinson's Disease. That link is Protein Disulphide Isomerase (PDI), a chaperone protein that is necessary...New guidelines improve diagnosis and quality of life for people with Parkinson disease
New guidelines developed by the American Academy of Neurology aim to educate physicians on the diagnosis and treatment of Parkinson disease and provide people with Parkinson disease an improved quality of life. The guidelines, released at the American Academy of Neurology 58th Annual Meeting in San Diego, Calif., April 1 8, 2006, and published in the journal Neurology, were developed through a r...A better tool to study role of iron in Alzheimer's, Parkinson's
Engineers have found a way to pinpoint and identify the tiny iron oxide particles associated with Alzheimer's and other neurodegenerative diseases in the brain....... The technique is likely to accelerate research on the cause of the diseases and could lead to the first diagnostic procedure for Alzheimer's in patients while they are alive....... "We're the first to be able to tell you both the lo...Male gene may explain higher incidence of Parkinsons in men
Scientists at Prince Henry's Institute, Melbourne, and the University of California, Los Angeles, have discovered that SRY, the male protein that forms the testes is also produced in the brain region affected in Parkinson's disease. This discovery may explain why men are more likely than women to develop this degenerative disorder....... "Our research has shown that a gene only present in males c...UCLA scientists find male gene in brain area targeted by Parkinson's
UCLA scientists have discovered that a sex gene responsible for making embryos male and forming the testes is also produced by the brain region targeted by Parkinson's disease. Published in the Feb. 21 edition of Current Biology, the new research may explain why more men than women develop the degenerative disorder, which afflicts roughly 1 million Americans.... ..."Men are 1.5 times more likely...Approaching a stem cell therapy for Parkinson's disease
High hopes have been pinned on the prospects of using stem cells to eventually be able to replace diseased or dead cells with new, healthy ones. In order to do this, the stem cells must be programmed to form cells with the exact speciality needed for the treatment of patients....... Parkinson's Disease is caused by the degeneration of dopamine-producing cells in a certain part of the brain. By st...Discoveries may advance stem cell therapy for Parkinson's, cancer patients
Two studies in the Jan. 27, 2006 Cell have yielded evidence that could prove a boon for stem cell therapies aimed at patients with Parkinson's disease and those with compromised immune systems due to intensive cancer therapy or autoimmune disease, according to researchers. The basic findings in mice revealed critical factors that determine the fate of one type of nerve cell progenitor and that se...Researchers identify gene mutation as major cause of Parkinson's in Ashkenazi Jewish patients
Researchers at the Albert Einstein College of Medicine of Yeshiva University and its Manhattan hospital affiliate, Beth Israel Medical Center, have found that a specific mutation in a single gene is a major cause of Parkinson's disease among Ashkenazi (Eastern European) Jews. The report will appear in the January 26 issue of The New England Journal of Medicine....... "Like the discovery of the BR...Fox Foundation grant funds major gene therapy advance for treatment of Parkinson's disease
An innovative gene therapy approach pioneered by Pennsylvania-based RheoGene Inc. will be further refined and tested in preliminary clinical trials within four years, thanks to a $4.2 million grant from the Michael J. Fox Foundation for Parkinson's Research (MJFF)....... A wholly owned affiliate of the University of Pittsburgh Medical Center (UPMC), RheoGene Inc. has developed technology to manag...A study conducted at the San Francisco VA Medical Center has identified a protein found in both mice and humans that appears to play a key role in protecting neurons from oxidative stress, a toxic process linked to neurodegenerative illnesses including Alzheimer's and Parkinson's diseases.... ...The study, led by Raymond Swanson, MD, chief of neurology and rehabilitation services at SFVAMC, ident...