Newly created cancer stem cells could aid breast cancer research
...of biology. Ince didnt set out to engineer these potent cells. As a post-doctoral researcher in the Weinbe...n in the new culture medium were 10,000 times more potent as tumor initiators and were the only ones able to metastasize. Thus genes that were previously thou...Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
...ocatechin gallate (EGCG), a catechin known for its potent antioxidant activity, and are currently being tested against a variety of cancers in clinical trials. This study was designed to see if green tea catechin concentrate had any effect on the levels of GST enzymes in healthy individuals − resear...Smokeless tobacco more effective than cigarettes for delivering dangerous carcinogens into the body
...mokeless tobacco exposes users to some of the same potent carcinogens as cigarettes. In the August issue of Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research, researchers at the University of Minnesota Cancer Center report that users of smokeless tobacco...New study suggests Concord grape juice may provide protection against breast cancer
...ncord grapes is particularly high in anthocyanins, potent natural antioxidants that give the juice its characteristic deep purple color. At the same time, drinking Concord grape juice can be good for the heart much like red wine. And so, with the link between alcohol consumption and breast cancer causing c...New data reveal pregnancies exposed to accutane despite risk management program
...nitoring program. Isotretinoin, one of the most potent teratogens, is marketed under several brand names to treat severe acne that does not respond to conventional treatments. More than 1.5 million prescriptions were written annually according to 2001-2002 FDA data. Isotretinoin is chemically related...UF to lead research on life-threatening fungus
...more accurate and less invasive ones. While more potent treatment regimens are improving prospects forpatients, so-called emerging pathogens -- viruses, bacteria and fungi -- are a growing medical problem, Wingard said. "With advancing medical technology and more powerful antibiotics,patients are living...Gene expression pattern could lead to improved treatment of pediatric septic shock
...ill a serious public health problem despite todays potent antibiotics and pediatric intensive care units. Consistent with Cincinnati Childrens increased emphasis on personalized and predictive medicine where diagnosis and treatment coincide with a person's genetic predisposition the study involves the ...New target for HIV/AIDS drugs and vaccine discovered
... help isolate and contain the infection until more potent reinforcements can be manufactured to eradicate the virus or bacteria. When DC cells can no longer adequately manage the immune response and when NK cells can no longer contain infections, the likelihood of survival without medical intervention is re...'Preconditioning' helps protect brain's blood vessels from stroke
...is natural means of self-defense, we might develop potent pharmaceutical means of either preventing stroke or minimizing stroke damage," he says. The findings appear as a special highlighted paper in the Journal of Neuroscience. According to the National Stroke Association, stroke is the third leading k...MIT IDs link between brain tumor proteins
...dge of c-Mets involvement could give researchers a potent tool to attack GBM tumors. When the MIT group treated tumor cells with drugs that inhibit EGFRvIII and c-Met, respectively, much lower doses were required to kill the cells than when either drug was given alone. There are several EGFRvIII inhibitor...Changing climate will challenge Northeast agriculture, CU expert warns
...trogen fertilizer, which produces nitrous oxide, a potent greenhouse gas....Scientists follow familiar TRAIL to new cancer therapy
...hers observed that TRAIL induced expression of two potent antiapoptotic molecules, Mcl-1 and cIAP2, and that c-Myc repressed both molecules. The researchers also discovered that the multikinase inhibitor sorafenib prevented TRAIL-mediated induction of Mcl-1 and cIAP2, and although it had little effect on...Scientists gain important insights into acute promyelocytic leukemia
...involving the transcription factor RARA, acts as a potent transcriptional repressor that interferes with gene expression and prevents normal differentiation of white blood cells. Previous work of these two groups suggested that PML/RARA self-association, called homodimerization, and posttranslational modifi...American Chemical Society's Weekly PressPac -- June 27/July 3, 2007
...n: New longboat delivery system could mean more potent anti-cancer drugs Moving ahead with guidelin...SE New longboat delivery system could mean more potent anti-cancer drugs Journal of the American Chemical Society Scientists are reporting development ...Translating form into function
...ategy works with other enzymes, it should become a potent tool to determine how key enzymes work in the body. And since enzyme action is crucial to disease, the technique opens an efficient route to drug discovery, Shoichet say. Schoichet a professor of pharmaceutical chemistry and an investigator in the Ca......In an animal model of sepsis, ISO-1 abolishes MIFs potent inflammatory abilities and the animals respond dramatically. They lived through the once-fatal sepsis. In patients in the throes of sepsis - an over-reactive and potentially fatal immune response to a bacterial infection - MIF concentrations are 1...Alzheimer's drug based on Purdue -- designed inhibitor begins clinical trials
...ation of this work. "The molecule is both highly potent and highly selective, meaning it does not appear to affect other enzymes important to brain function or cause harmful side effects," Ghosh said. "It took years of work and evaluation of hundreds of molecules to achieve one with the strength and safet...Weizmann Institute scientists develop a general 'control switch' for protein activity
... serve as targets for new drugs. Beyond offering a potent tool that can be applied to any protein, the method has an important advantage compared with other techniques: It allows the total and precise control over the activity of an engineered protein. Such activity can be brought to a desired level or retu......n, said OMalley. It prevents you from activating a potent factor in the cells that just keeps the clock running and the gene continuing to be expressed. In that scenario, the result could be cancer, too much growth or an abnormal function. It means theres a fixed length of time that the molecule can work. ...