Tag: "preclinical" at biology news

Amgen investigational therapy, AMG 162, increased bone mineral density with twice yearly injection

... bone resorption compared to other therapies. The preclinical studies also showed that inhibition of RANK Ligand resulted in improvements in bone mass, bone density and bone strength, indicating that bone quantity and quality were improved. These studies, conducted by Amgen, also documented that inhibition of ...

Cooperation to create a new tuberculosis vaccine

...tner for this challenging mission. This still is a preclinical stage project, but our cooperation will add significant value to this new vaccination approach. There is a significant commercial perspective in developing as well as in developed countries. If our tests prove successful we will decide if we carry on...

Paratek Pharmaceuticals presents multiple sclerosis data at Society for Neuroscience annual meeting

Paratek Pharmaceuticals, Inc. announced results of preclinical studies demonstrating that a new class of compound...l tetracyclines, has shown promising activity in a preclinical animal model of multiple sclerosis (MS). Affecting approximately two million people worldwide, MS i...

Mayo researchers define celecoxib pathways and mechanisms for tumor reduction

...d Mukherjee. "This model allows us to proceed with preclinical studies that must precede clinical trials in order to enable us to develop efficient therapeutic strategies with targeted molecular therapies." Contributing to this report along with Mukherjee were Mayo Clinic cancer researchers Gargi Basu, Ph....

Researchers call for studies on role of BRCA1 mutations in chemotherapy response

...orthern Ireland, and colleagues reviewed published preclinical and clinical evidence. Preclinical studies include...used to treat breast and ovarian cancers. However, preclinical evidence suggests that BRCA1 function is necessary for spindle poisons to work. The authors recommen...

Efforts to clone primates move forward

...te stem cells is vitally important to evaluate the preclinical safety and immune-tolerance of stem cell transplan... not violate federal or state laws, and allows for preclinical investigations that would not be ethically feasible in humans. Our hope is to help advance the precl...

Potent anticancer drug increases function of axons in mouse model of neurodegeneration

(Philadelphia, PA) In a preclinical efficacy trial, the cancer drug paclitaxel (Paxceed)which exerts its effects by binding to and stabilizing microtubules inside cellsreduced the adverse effects of Alzheimer's disease (AD)-like pathology in a mouse model. Researchers from the Universi...

Stem cell therapy for ailing hearts

... editorial accompanying the USF study. "Additional preclinical animal studies are warranted and should focus on examining the mechanisms that mediate the functional effects of stem cell transplantation." The USF researchers compared HUBC-treated rats to both untreated rats (those receiving only a sugar water pla...

UCLA researchers detail the evolution of quantum dot imaging in the journal Science

...d to advancing the routine use of quantum dots for preclinical and clinical studies," said Dr. Sanjiv Gambhir, director of the molecular imaging program at Stanford. "Our unique partnership is leading to many new discoveries and the best is yet to come." The other advance outlined in Science details how Weiss an...

New nicotine-like imaging agent holds promise in PET studies, may help diagnose Alzheimer's disease

...ood PET imaging agent for this receptor will allow preclinical and clinical studies, leading to better understanding of different medical conditions and eventually helping in their diagnosis and treatment, said Mukherjee. Additional research and work with animal subjects must be completed before this tracer can...

New drug may be formidable adversary for hard to treat leukemia

...te the effectiveness of AMN107 demonstrated in the preclinical studies reported here, it may be possible to either use AMN107 in selected patients with imatinib resistance, or to use both agents together, simultaneously or sequentially," says Dr. Griffin. The researchers are hopeful that combined therapy may su...

Defensins neutralize anthrax toxin

...ped a new therapeutic strategy against anthrax. In preclinical studies, these scientists showed that defensins neutralize the lethal toxin of anthrax bacilli and thus can prevent its deadly effect. Whilst defensins are well known to kill bacteria, toxin neutralization represents a novel function of defensins. De...

Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals

...Medicine, hold considerable promise for conducting preclinical studies in the emerging field of molecular therape...e adapted for many tissue types and for a range of preclinical uses in conjunction with emerging molecular therapeutic strategies," Ahrens said. Ahrens' new appro...

Gene mutation protecting against malaria linked to prostate cancer incidence in African-American men

...ercent of African-Americans have the mutation. The preclinical study was presented Tuesday, April 5, at the American Society of Investigative Pathology sessions of Experimental Biology 2005. The gene mutation prevents expression of the Duffy antigen/receptor for chemokines (DARC) on red blood cells. The DARC ori...

Researchers test new therapy for advanced melanoma

...h. "We were very encouraged by the results of the preclinical studies." Dr. Heller said. "We're hoping this translates into a beneficial treatment for patients." The Phase 1 clinical trial by Moffitt and Genetronics Biomedical Corp is evaluating the safety of the electroporation technology in treating patients ...

Scientists making advances receive international awards

...zes an individual or research team for outstanding preclinical research in the fields of medicinal chemistry, biochemistry or tumor biology as related to drug discovery that has implications for the improved care of cancer patients. The prize was established to honor Dr. Bruce F. Cain, whose scientific interest...

Gladstone investigator Steve Finkbeiner wins prestigious Lieberman Award

...search, including the development of mouse models, preclinical testing, studies of protein-protein interactions, strategies for gene therapy, intercellular signaling in striatal neurons and the development and planning of clinical trials. It has two offices, one in Santa Monica, California, and another in New Yo...

Next-era targeted therapy overcoming Gleevec's shortcomings

...edical treatment "in which the integration between preclinical researchers and clinical oncologists is seamless," Giles says. "I don't work in a lab. I spend all my time with patients. But clinicians are now using molecular endpoints every day and in every way to direct our therapy and to design protocols. It is...

UW-Madison gains two new stem cell programs

...ransplanted cells, non-human primate resources for preclinical safety and efficacy testing, and imaging resources to track the incorporation of transplanted cells. Kamp, who first identified and characterized the different types of heart cells that can be derived from human embryonic stem cells, says the new pr...

Use of PET can reduce, may eliminate more strenuous drug development trials with animals

...on, small animal imaging significantly reduces the preclinical evaluation time for therapeutic pharmaceuticals, possibly speeding the way for innovative drugs to patients, said Welch. Since there is no public registry of animal researchers, Welch estimates that there may be as many as 12,000 academic and private...

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(Date:7/25/2014)... girls reach puberty is influenced by ,imprinted genes,a subset of ... gene. This is the first evidence that imprinted genes ... of this study were published today in the journal ... menarche, is a marker for the timing of puberty in ... varies between girls, is an inherited trait, and is linked ...
(Date:7/25/2014)... time, Spanish researchers have detected an unknown interaction between ... are introduced into a droplet of salt water and ... crystallisation to create biomineralogical biosaline 3D morphologically complex formations, ... bacteria are revived. The discovery was made by chance ... of the Astrobiology journal and may help ...
(Date:7/24/2014)... wildlife loss leads to conflict among people around the ... Society (WCS) Health & Ecosystems: Analysis of Linkages (HEAL) ... approach to tackle global biodiversity decline. , The harvest ... world,s people and provides protein for more than a ... no surprise that today,s unprecedented loss of wildlife, is ...
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