Researchers find protein that makes long-term memory possible
...d in Nature that, in a laboratory simulation using rodent brain cells, BDNF fostered changes in the cells indicative of memory. In 1998 Nobel laureate Eric Kandel reported that tissue plasminogen activator was also involved in the formation of long-term memory. Tissue plasminogen activator, or tPA, is bes...Using fruitflies to examine alcohol tolerance
...t," said Crabbe. "This is interesting because the rodent literature suggests that rapid and chronic tolerance appear likely to represent early and later versions of the same set of brain adaptations to alcohol. The second finding of interest concerns mutant flies with a defective ability to produce octop...Yerkes researchers to present array of new data at Society for Neuroscience Meeting
...s. (1 pm 2 pm.) used gene therapy and transgenic rodent models to demonstrate that activation of the vasopressin receptor in a specific area of the brain is necessary and sufficient for normal social recognition in mice. This study illustrates the importance of the gene therapy and transgenic technology a...Genetically endowed worm may substitute for rodents in some toxicology testing
...ually replace, the need for expensive, large-scale rodent studies The tiny roundworm has long been a favorite among molecular biologists and health researchers since its 959 cells contain many genes and proteins that function similarly to those of higher animals, including humans. Freedman, an associate pr...Say goodbye to Rudolph and other reindeer if global warming continues
...ment. He admits that there is no fossil record of rodent or small mammals to support the findings in Grotte XVI, but contends reindeer biologists have ignored summer temperature. "Reindeer cannot physiologically tolerate high summer temperatures," he said. "They have almost no sweat glands and keep the...Read your shampoo's label: Study finds common ingredient stunts developing neurons of rats
... needed to determine what effect MIT would have in rodent models, both at the cellular level and to a developing nervous system, our results thus far suggest there is potential that everyday exposure to the chemical could also be harmful to humans. I would be particularly concerned about occupational exposu...First analysis of chicken genome offers many new insights
...that they are more similar to human telomeres than rodent telomeres. Scientists believe telomeres shorten the DNA slightly every time a cell divides, eventually making it impossible for the cell to divide. This inability to renew through cell division is thought to be a primary component of the structural a...Researchers compare chicken, human genomes
... are 75 percent identical on average, than between rodent and human gene pairs, which are 88 percent identical on average. Differences between human and chicken genes were not uniform across the board, however. Chicken genes involved in the cell's basic structure and function showed more sequence similarity...Scientists reveal molecular secrets of the malaria parasite
... genome annotation was performed on two species of rodent malaria ( Plasmodium chabaudi and P. berghei ); ...s of the two draft genomes with those of the first rodent malaria parasite to be sequenced, Plasmodium yoelii. The first author of the paper is Hall, a TIGR A...Protein stops growth of brain tumor, OHSU study shows
...ways view with caution new and exciting results in rodent models since they may or may not translate in humans." Scientists used herstatin to treat human glioblastoma cells grown in culture and implanted in rats. "We saw a few tumor cells at the injection site, but they never proliferated," Clinton said. He...A gene's fist 'kiss' sets off that affair known as puberty
...y, as well as learn about KiSS-1, which in earlier rodent studies had been identified as a molecule that activates a signal receptor of GPR54, the researchers looked to the nonhuman primate, the only animal with a reproductive system in common with the human's. The onset of puberty becomes official when gon...Beer-drinking rats count calories better than many people, UF researchers say
...eople may ignore the internal stop signs. But the rodent imbibing experience in previous experiments didn't parallel the human one. Rats would drink the ethanol and water that scientists mixed for them only if nothing else were available -- not the typical atmosphere you'd find at a tailgate party. In addi...Gene therapy for Parkinson's disease moves forward in animals
... the substantia nigra. That's been shown before in rodent models, but it's encouraging to see data that it works in higher animals like monkeys." Meanwhile, in separate experiments with rats, researchers used gene therapy to completely reverse abnormal movements called dyskinesias in some of the animals, su...Climate change to bring a wave of new health risks
...l in the American southwest, setting the stage for rodent population booms and increased risk of exposure to...us, a sometimes deadly disease transmitted through rodent urine and droppings. Such events can be predicted with confidence, and if higher risk is forecast, p...JCI table of contents April 1, 2005
... called the Jak/Stat pathway. The researchers used rodent models of liver damage that causes hepatitis and liver damage involving immune T cells. Their aim was to characterize mechanisms involved in mediating IL-6-dependent protection. They demonstrate that IL-6/gp130/Stat3dependent expression of two prote...New ways to ease liver disease
... called the Jak/Stat pathway. The researchers used rodent models of liver damage that causes hepatitis and liver damage involving immune T cells. Their aim was to characterize mechanisms involved in mediating IL-6-dependent protection. They demonstrate that IL-6/gp130/Stat3dependent expression of two prote...Vampire bats keep out of trouble by running
...ster South American athletes such as the agouti, a rodent about the size of a hare, which might wake up and take a swipe at the nocturnal visitor. It remains unclear exactly what the native prey were before the introduction of cattle, he adds. The Cornell zoologists plan to go a step further and compare th...Studies expand understanding of X chromosome
...y identical. Comparing gene order in the human and rodent sequences showed several segments had reshuffled in the rodent lineage, and an interesting, 9 million base pair region appears to have been deleted from the rodent...JCI table of contents June 1, 2005
...e airway associated with asthma. The authors use a rodent model of experimental asthma to show that antigen-specific CD4+ T cells infiltrate the airway wall, where they may act on airway smooth muscle to regulate muscle cell proliferation and death. This increases the amount of smooth muscle in the airways,...Mosaic mouse technique offers a powerful new tool to study diseases and genetics
...ed method for creating a "genetic mosaic mouse"--a rodent whose body is genetically engineered to produce small clusters of cells with mutated genes. The new technique, called Mosaic Analysis with Double Markers (MADM), was developed in the laboratory of Liqun Luo, professor of biological sciences at Stanf...