Commandeering cellular machinery: recognition mechanism to detect small molecules
...ld have been impossible to test using conventional screening methods. However, Doyle and his research team use...e. This allows us to do highly parallel and rapid screening to find a few functional receptors in a large collection of nonfunctional receptors." The receptors ...An embryonic stem cell model for Parkinson's disease
...ecular mechanisms of neurodegenerative disease and screening potential neuroprotectant drugs. The authors are hoping to extend their work to human embryonic stem cells, but their work is limited by the availability of such cells under the current NIH guidelines. ...September/October 2004 Annals of Family Medicine tip sheet
...nificant age-related disparities in several cancer screening interventions, including colorectal screening, mammography screening and PSA testing. The findings indicate a relative underuse of colorectal screening by younger adults...Channel protein converts vibrations to electrical signal
...al location as this channel," he said, "but we are screening some unmapped deafness families." In addition to the evidence that TRPA1 forms a mechanically-gated channel in the hair cells, the structure of the protein suggests that it may play another role. Previous biophysical studies had indicated that a spr...The CF Foundation urges all states to include newborn screening for cystic fibrosis in test panels
...the implementation of routine cystic fibrosis (CF) screening in all newborns. In addition, the Centers for Dise...endations that all states should consider routine screening for CF in all newborns. CF Foundation-supported research and peer-reviewed evidence conducted and g...Combination hormone therapy doubles breast density and quadruples risk of abnormal mammograms
...cancer risk as well as decrease the sensitivity of screening mammography," McTiernan said. "Our results suggest that avoiding such hormone therapy may help improve the sensitivity of mammograms for detecting early breast cancers at a stage when they are most treatable." In addition, McTiernan and colleagues s...Urine testing might prove to be an alternative screening test for cervical cancer
Urine testing might prove to be an alternative screening test for cervical cancerSeattle -- A study involvi...ple urine test might provide an alternative to Pap screening for cervical cancer. In most of the world, cervical cancer is the second leading cause of cancer-rel...Hormone therapy's effect on breast density is not the same for all women, Group Health study finds
...om 46,436 women who had received more than 100,000 screening mammograms at Group Health Cooperative between January 1996 and June 2002. At each mammogram, the women completed a questionnaire on breast cancer risk factors, hormone use, health history, and demographics. Aiello and her colleagues analyzed this in...Scientists fear threat of second wave of 'mad cow' prion infection
...: Update on Canadian Consensus Conference on vCJD screening of blood donors, implications for safety and availability of the blood supply. Paul M. Ness, MD. Director, Transfusion Medicine, The Johns Hopkins Hospital; Editor-in-Chief, Transfusion; former president, AABB: Overview of benefits of unive...Study demonstrates Cenestin reduces sleep disturbances/night sweats in post-menopausal women
...urgical removal of the uterus, received a baseline screening including a physical exam, medical and sleep history, and completed a two-week diary reporting sleep quality, sleepiness and hot flashes. After a baseline of three nights taking placebo, participants were randomized to either 0.625 mg of Ce...Genetically endowed worm may substitute for rodents in some toxicology testing
...worms' developing internal organs. Toxicity screening during development evaluates how pre-selected amounts of chemicals affect groups of animals as they grow. Even if the animals do not sicken or die as they mature in the presence of toxicants, the chemicals may affect their organs in ways that can be ...Trojan-horse therapy blocks buildup of Alzheimer's plaque
...anies to develop A peptide inhibitors -- mainly by screening for small molecules that would bind to those aggregates and hoping that they would prevent further aggregation," said Crabtree. "But instead, what happens in virtually all cases is that those molecules just fit right into the aggregates and don't pre...Study reveals genetic link to colon cancer
...ntification of potential high risk cases to see if screening and further testing of the patient and family members is required. This research builds on previous studies that suggest the child of a couple where both parents are carriers has a 1:4 chance of developing a severe form of colon cancer. As m...MIDI, Inc receives Official Methods(SM) status for the confirmatory ID of the anthrax pathogen
...mental sources, while at the same time proactively screening for potential agents of bioterrorism. Suspicion of a bioterrorism agent is not required for effective use of the system. With AOAC Official Methods SM status, laboratories will now have a highly accurate confirmatory identification system that can...GlaxoSmithKline awards $250,000 in research grants for research on drug therapies for HIV/AIDS
...ant for his novel, cell-based high throughput drug screening system to identify potential inhibitors of HIV transcription. "HIV gene expression is dependent on a unique viral protein, called HIV-1 transactivator (HIV-1 Tat)," Dr. Kutsch said. "All previous attempts to identify HIV-1 transcription inhibitors,...Researchers discover new way to boost grain crops' drought tolerance
...an enzyme required for the production of ethylene, screening thousands of plants for naturally occurring mutants that were deficient in the enzyme. The researchers isolated several such plants, and one in particular that produced substantially lower levels of the hormone. Leaves from this mutated plant remain...Ubiquitination in real-time: A world first at the Universit de Montral
...he missions of GRUM is to establish a high content screening facility that would allow the identification of the chemical components with therapeutic potential. The recent results on observation and monitoring of ubiquitination in real time, in living cells, will help to better target therapeutic molecules fro...Six reporters reach the 'Pinnacle of Excellence'
...integrity, all entries are assessed by independent screening and judging panels, explained Weisman, sponsor of the AAAS Science Journalism Awards. For this reason, winners report that the awards program offers significant career visibility and acknowledgement of achievement: Past winner Natalie Angier of The ...Columbia researchers identify drug as therapeutic candidate for spinal muscular atrophy
... vary daily during the course of a high-throughput screening experiment. Additionally, SLIMS automatically identifies and corrects the systematic errors that are common with the robotic technologies used in screening. ...Academy meeting highlights advances in detecting Amish, Jewish, and Icelandic genetic diseases
...ul use of molecular genetic techniques and genetic screening of populations? To examine advances in genomic medicine as well as ethical concerns, the New York Academy of Sciences' Genomic Medicine Discussion Group Section is sponsoring a meeting, Genetic Studies in Special Populations, on Wednesday, December...