UNC scientists identify sticky protein in sickle cell red blood cells
...f Alpha-4Beta-1 and an increase in red blood cells sticking to the blood vessel wall, said Brittain. "Even though sickle cell patients are particularly vulnerable to blocked blood vessels, the signaling mechanisms identified in sickle reticulocytes seem to be present in reticulocytes found in oth...Touching research: How white blood cells navigate
...f blood flow are crucial to the process. When the sticking process goes awry, disease occurs. Painful and harmful inflammation occurs when white cells are extremely active. Autoimmune diseases like diabetes, multiple sclerosis and lupus happen when our white blood cells attack our own tissues somehow our ce...Molecule that helps DNA replicate may make good target for cancer therapy
...ach to the strands to keep them from spontaneously sticking together again. Only then can the star of the show--DNA polymerase alpha, the enzyme complex that synthesizes new DNA strands--be escorted to the specific sites on the DNA strands where it can attach and go to work. "The big question was, How is poly...Delays in cutting greenhouse gasses could harm environment
...o achieve those limits. Not acting promptly or not sticking to the target could prove highly disruptive, if not devastating." Oppenheimer and O'Neill are following up their work with efforts to improve the estimates of how coral reefs, ice sheets and other major systems are likely to react to different warmin...New approach studying protein structure could advance drug development
...o tell the difference between a ligand that's just sticking to the surface of a protein (a drug that may have no effect) and a ligand that's actually changing the structure (a drug that is more likely to be effective). In the past, detecting this difference required the use of several techniques combined. N...$6.7 million for bionic war on disabilities
..., Normann says. "To go from a bundle of wires sticking out of somebody's head to a totally implantable system that is invisible will be a major advance in this technology," he adds. Normann has spent more than a decade developing the Utah Electrode Array so it eventually can be implanted in the b...Study finds direct association between cardiovascular disease and periodontal bacteria
...f new data proposing a link. Since then, a major sticking point in advancing the research has been simply how to pursue the hypothesis. Lacking the scientific tools to track oral bacteria in the body over several decades to determine if they directly trigger heart disease, most previous studies pursued ind...Survivors to revisit the polio scare
...ed respirators. "I had space for four patients all sticking their heads out from this room with their bodies inside," wrote Children's physician James Wilson, "and we could get inside with them and care for them." Clinicians also gave care through portholes, initially purchased from a Boston shipyard; if a po...Polymers with copper show promise for implanted sensors
...bits platelet function and prevents platelets from sticking to the surface of the blood vessels." Over the years, Meyerhoff and collaborators have developed nitric oxide-releasing polymers, then coated sensors with the polymers and implanted the sensors into the arteries of laboratory animals. "We always see ...New NSF-AAAS report highlights 'learning communities,' other STEM educational strategies
...decline of iron mining and paper production -- are sticking with the program, seemingly against all odds. Key to the engineering program, director Ronald Ulseth said, is an educational strategy called a "learning community." Now common to humanities programs, learning communities emerged much more recently w...Enzyme's newly discovered role may make it target for arthritis treatment
...working to determine what molecules cathepsin G is sticking to and interacting with on the surfaces of neutrophils and other cells....Research casts doubt on circulating stem cells
...aits believe by the body to be no longer needed by sticking a label on them a sort of molecular "Don't use!" sign. "We have tried to remove this label by chemical means, too, in an effort to get the nuclei of the bone marrow-derived cells to start producing muscle proteins again," says Professor Wernig. "Whi...Blocking a premature aging syndrome with anticancer drugs
... proper integration into the lamina. If progerin's sticking to the inner nuclear membrane is indeed the culprit in nuclear blebbing and the root of the HGPS defect, Capell reasoned that he could prevent these defects by blocking farnesylation of progerin. Capell's hunch proved correct. When he changed one am...Viagra's hidden help for wildlife
...(TCM) to Viagra to treat erectile dysfunction, but sticking with tradition for ailments such as arthritis, indigestion and gout, according to new research published in Environmental Conservation. The finding supports a prediction made by Australian and Alaskan researchers at the advent of Viagra's commercial ...Geologists use biotools to understand geosystems
... understand when bacteria will stick? What are the sticking efficiencies of bacteria on minerals? If they are ...y (Cail) Bank did her dissertation research on the sticking efficiencies of Enterococcus faecalis bacteria, which causes opportunistic urinary tract infections ...In Western bluebird as well as human families, accumulated wealth encourages stability
...that sons in the depleted territories, rather than sticking around through the winter, left at the same time as their sisters in late summer. And they seemed to leave of their own volition, rather than being kicked out by their parents. "We looked extensively and did not see much aggression directed at offspr...Grabbing addiction by the tail
...e receptor into the cell. Without its business end sticking out into the synapse, or space between neurons, the receptor no longer works. Wang's peptide tricks the cellular machinery into tugging on it instead of the receptor's tail. "Once it gets inside the neuron, the peptide competes with the receptor for...JCI table of contents, February 23, 2006
...th an antibody prevented the progenitor cells from sticking to blood vessels, from migrating to newly formed vessels, and from changing into different cell types. Together these studies support a potent role of VLA-4 in the regulation of bone marrowderived progenitor cells in wound repair and migration. The a...Drawing a crowd: How progenitor cells are recruited to tumor blood vessels from the bone marrow
...th an antibody prevented the progenitor cells from sticking to blood vessels, from migrating to newly formed vessels, and from changing into different cell types. Together these studies support a potent role of VLA-4 in the regulation of bone marrowderived progenitor cells in wound repair and migration. The...New test of snow's thickness may 'bear' results key to polar climate studies, wildlife habitat
... "It's not as easy as going into your backyard and sticking a ruler in the snow to measure the snowfall," said Thorsten Markus, a cryospheric scientist at NASA's Goddard Space Flight Center, Greenbelt, Md., and co-principal investigator of the field campaign. "Measuring snow's thickness is something that peop...