Multinational research: protecting ecology means understanding people, too
...on." They put heavy emphasis on applied. They have targeted the U.S.-Mexican border, Central America, the Caribbean basin, the Western Amazon and Gran Chaco, a sparsely populated area between Argentina, Paraguay, Brazil and Bolivia. If you picture the three sides of a triangle conducting interdisciplinary r...Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
...on via diverse genetic abnormalities. Importantly, targeted disruption of the classical NF-κB signaling blocked myeloma proliferation and induced cell death. These genetic and functional data provide a molecular framework for the rational development of NF-κB pathway inhibitors for the therapy of MM...Gene regulation, not just genes, is what sets humans apart
... and reproduction spread throughout a species, has targeted the regulation of many genes known to be involved in the brain and nervous system and in nutrition, said Ralph Haygood, a post-doctoral fellow in the laboratory of Duke biology professor Gregory Wray. Haygood is lead author in a report on the resea...ESF EURYI award winner aims to stop cancer cells reading their own DNA
...th the long term goal of developing more precisely targeted molecular medicines for a variety of diseases involving disruption to normal cellular functions and not just cancer. Dekkers work has already shown great promise, and she has been able to predict what effect certain antitumor drugs would have on the...Evolution is driven by gene regulation
...y map these interactions and identify the specific targeted promoters, said Snyder. We were startled to find that even the closely related species of yeast had extensively differing patterns of regulation. In this study, the authors found the DNA binding sites by aiming at their function, rather than their ...A study by the MUHC and McGill University opens a new door to understanding cancer
...er cell growth is vital to the development of more targeted treatments for the disease. An article published in the August 3 issue of Molecular Cell provides a key to these mechanisms that may prove crucial in the future. The paper is co-authored by Dr Morag Park, Director of the MUHC Molecular Oncology Group...AAAS analysis finds Congress would add billions to FY 2008 R&D investment
...R&D) budget, with much of the proposed new funding targeted for environmental, energy and biomedical initiatives, according to a new report by the R&D Budget and Policy Program of the American Association for the Advancement of Science. Congressional appropriations measures also propose to meet or exceed Pr...Story tips from the US Department of Energy's Oak Ridge National Laboratory, August 2007
...pment of two new lines of wireless sensor products targeted at manufacturers by industry heavyweights Honeywell and General Electric. The instrument offeringsRF ValProbe by GE and OneWireless by Honeywellrepresent a new generation of wireless technology that taps industry-standard approaches to radio frequenc...Defects in critical gene lead to accelerated lung tumor growth
...important for lung cancer and to develop therapies targeted in a way that can help human patients. To determine whether the model mirrors the genetic events of human lung cancer, the researchers analyzed DNA from 144 non-small cell lung cancer patients treated at UNC and affiliated hospitals. Defects in LKB...Census of Marine Life historians detail collapse of bluefin tuna population off northern Europe
...iant bluefins found off the north of Ireland fish targeted by Irish sport fishers and Japanese long line vessels today. In a paper for the journal Hydrobiologia, CoML and marine scientists from Canada, Ireland and the U.S. (Michael Stokesbury, Ronan Cosgrove, Andre Boustany, Daragh Browne, Steven L. H. Teo...Neurosciences and music meet in Montreal
...ain, and music rehabilitation. The event is mostly targeted to medical professionals, neuroscientists, neurologists, psychologists, educators, music therapists, musicologists, and sound engineers. The conference will be preceded, on June 25th, by a Workshop on research design and methodology in music and ne...U-M researchers find family of 'on switches' that cause prostate cancer
...new diagnostic tests or screening tools as well as targeted treatments for cancer and other diseases, with the key being to translate these laboratory discoveries into clinical applications. Chinnaiyan and his team have received numerous awards and honors, including the American Association for Cancer Rese...Aggressive therapy best for certain AML patients
...er understand this disease and to develop curative targeted therapies. ...Molecule blocks gene, sheds light on liver cancer
...search led by Patel had shown that miR-21 probably targeted PTEN, and this study confirmed that. Furthermore, the researchers showed that adding high levels of miR-21 to normal liver cells caused PTEN levels to drop. They also traced the chemical pathways that increased the cells' abilities to proliferate,...Investigating antibiotic use in acute care patients
...g to delays of some days before the bacteria to be targeted can be accurately identified. Dr Chin said for this reason it is important to develop a molecular detection method that can identify antibiotic resistance signatures of entire microbial communities. "Our hope is that this kind of information wi...Injection drug use and HIV and HCV infections among Ontario prison inmates
...rom Apr. 1, 2003, to Mar. 31, 2004. They recommend targeted education and prevention efforts. In a related commentary, Richard Elliott, deputy director of the Canadian HIV/AIDS Legal Network, comments on the continued refusal by federal and provincial governments to implement evidence-based harm reduction m...MIT model could predict cells' response to drugs
...model that could predict how cells will respond to targeted drug therapies. Models based on this approach could help doctors make better treatment choices for individual patients, who often respond differently to the same drug, and could help drug developers identify the ideal compounds on which to focus thei...Hepatitis C helicase unwinds DNA in a spring-loaded, 3-step process
... in the viral genome, and that it is already being targeted in pharmaceutical studies to combat Hepatitis C infection. It also belongs to the largest of four helicase superfamilies, so the new findings could have relevance across many organisms. ...Scientists discover new way to study nanostructures
...ion of the dimer about the inter-tip axis. Ensuing targeted experiments demonstrated that the resonance peaks disappear gradually as one approaches the superconducting transition temperature from below, while their positions do not change. These observations, exhaustive qualitative and quantitative agreement ...CTRC enrolls first patients in novel phase II study for sarcoma -- living virus destroys cancer cell
...cer cell and kill it. REOLYSIN typifies the true targeted therapy approach that seeks to use fundamental differences between cancer and normal cells as the basis for effective anti-cancer approaches and we are thus very excited about the this study, said Francis Giles, MD, director of the CTRC Institute for...