Tag: "transcription" at biology news
Genetic variation helps to understand predisposition to schizophrenia
...genes to be coded for proteins. A protein called a transcription
factor binds to the promoter and helps other prote...xpress the gene. When the promoter is altered, the transcription
factor may not bind properly and impair genetic expression. Law and colleagues showed that alteratio...
Evolution is driven by gene regulation
...ind DNA regulatory regions have been identified as transcription
factors mediating gene regulation, we have now sho... rather than their sequence. First, they isolated transcription
factors that were specifically bound to DNA at their promoter sites. Then, they analyzed the sequenc...
Penn researchers discover how key protein stops inflammation
...3 interacts with p50, a protein that inhibits gene transcription
by binding to DNA. p50 turns off the DNA region coding for inflammation, halting the response to infection, explains Chen. Without Bcl-3, Chen says p50 cannot stop the inflammation response, but instead will become degraded very fast, through ubiqu...
Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
...d KLF2 coordinates with a related and well-studied transcription
factor, EKLF, in the regulation of embryonic globi...likely means that EKLF and KLF2, which are related transcription
factors, regulate overlapping groups of genes in developing red blood cells. In the absence of both ...
In a first, Einstein scientists discover the dynamics of transcription in living mammalian cells
... of Yeshiva University have measured the stages of transcription
in real time. Their unexpected and surprising findings have fundamentally changed the way transcription
is understood. The researchers used pioneering microscopy techniques developed by Dr. Robert Singe...
Discovery in plant virus may help prevent HIV and similar viruses
...s HIV and the pararetrovirus CaMV both use reverse transcription
to recruit the host's proteins in order to reprodu...This must also reflect a fundamental mechanism for transcription
inherited by these viruses." Humans and organisms used for research, such as fruit flies and the t...
Huntington's disease study shows animal models on target
... for preclinical testing of drugs that affect gene transcription
in Huntingtons Disease. ...
Gene-transcription machinery seen poised for action, held in check until needed
...at, when in place, appears to be able to pause the transcription
process after the needed machinery has been assemb... as RNA polymerase II at its core is released and transcription
is set into motion. The research was done in yeast, an often-used model organism for genetic studies...
Study identifies new gene therapy tools for inherited blindness
... photoreceptor proteins. The three genes, known as transcription
factors, act by binding to DNA in a way that turns... several hundred potential binding sites for these transcription
factors," Corbo explains. Through a variety of experiments, Corbo's group confirmed that 19 of the ...
Researchers watch antibiotics, bacteria meet at atomic level
...that this mobile loop is a hot spot for regulating transcription
in all living organisms, not only by using antibiotics but also by manipulating cellular factors, she said....
News tips from the Journal of Neuroscience
...n. This conditioning effect is mediated by altered transcription
of multiple genes and involves both enhanced axona...on by myelin. Seijffers et al. concentrated on the transcription
factor ATF3 as a candidate mediator of the enhanced growth because ATF3 is expressed after periphera...
New proteomics research promises to revolutionize biomedical discovery
...proteins known to exert specific functions in gene transcription
and RNA processing, the Coulombe team has defined an intricate network of 805 high-confidence interactions that connect together 436 different proteins. Among them, many proteins of previously unknown function can now be inferred putative functions b...
Cells take risks with their identities
...s looser DNA packaging configuration and thus with transcription
initiation. They worked with embryonic stem cells,...nals, inactive developmental regulators primed for transcription
could roar to life. This is a new model for regulation of the developmental regulators, Young main...
Scientists gain important insights into acute promyelocytic leukemia
.... In APL, the fusion protein, always involving the transcription
factor RARA, acts as a potent transcriptional repr...chanisms reported with various leukemia-associated transcription
factors," conclude Drs. So and Dong. A separate group, led by Dr. Hugues de Thé from CNRS/Un...
Internal clock, external light regulate plant growth
...posed to light. So while the internal clock drives transcription
of the genes to produce proteins, external light r.... The PIF 4 and 5 proteins are thought to act as transcription
factors that turn on other genes involved in growth....
Tiny tweezers and yeast help St. Jude show how cancer drug works
... DNA strands. However, instead of duplicating DNA, transcription
machinery makes an RNA message, which is then tran...f DNA produces positive supercoils in front of the transcription
machinery, while negative supercoils form behind it. When the investigators added topoisomerase, ...
Scientists discover role of enzyme in DNA repair
...etic information into functional proteins. While transcription
ensures accessibility to DNA lesions, Casellas won...was possible for repair enzymes to do their job if transcription
continued once DNA had been damaged. Imagine a piece of DNA as a zipper, he says. The head of the zi...
St. Jude study shows genes play an unexpected role in their own activation
...ver. The on switch, a protein called CREB, is a transcription
factora molecule that binds to a section of DNA ne.... Previously, scientists thought that a particular transcription
factor uses the same co-factors to activate all its target genes. The new findings showed that ph...
New findings challenge established views on human genome
...for proteins; regulatory elements that control the transcription
of genes; and elements that maintain the structure... providing new perspectives on everything from DNA transcription
to mammalian evolution. In particular, we gained significant insight into DNA sequences that do not ...
ENCODE map changes view of the human genome landscape
... span the areas of chromatin and replication, gene transcription
and regulation, and evolutionary constraint, some ...erence: Denoeud F. et al. 2007. Prominent use of 5 transcription
start sites and discovery of a large number of additional exons in ENCODE regions. Genome Res. 17: 7...
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