NIH funds first nationaL SNP genotyping center at Broad Institute
...fectively carry out large-scale studies of genetic variation in humans and animals to advance disease gene identification. Research on genetic variation is aimed at improving the diagnosis and treatment of numerous diseases of humans that may have signi...September/October 2004 Annals of Family Medicine tip sheet
...cal Care Survey, researchers found little seasonal variation in the patient problems primary care physicians diagnose and treat, though they did find variation in the rank order of the diagnoses depending on the season. Concluding that diagnoses collected at ...'Junk' DNA may be very valuable to embryos
... random insertions of these elements can introduce variation in genes, potentially altering their function." The researchers think that expression of retrotransposons during very early stages may contribute to the reprogramming of the mammalian embryonic genome, a prerequisite for normal development. ...Study in Royal Society journals presents evidence for inherited factors in homosexuality
... We have identified several genes associated with variation in male reproductive success (ie ability to sire offspring when in competition with other males). We measured the expression level of over 14,000 genes in the fruit fly and identified 27 that were strongly associated with differences in male reproduc...Highlights of American Anthropological Assoc. meeting
...esearch. This session asks "how are race and human variation related to health?" (10.15-Noon) Anthropology Beyond Bagdad: A Roundtable Discussion. (1.45-3.30 p.m.) The Anthropology of Crisis in the Middle East: Presenters discuss the dangers they personally encounter in the field violence, terror, i...Laboratory test of evolutionary theory confirms importance of links between populations
...ons. Forde also found that gene flow increased the variation in coevolutionary dynamics through time. "We had a pretty simple system, but the results were relatively complex. We found that adaptation can vary in both space and time across a heterogeneous landscape. It's mind-boggling to think about how these k...... the brain to ease symptoms, and why there is wide variation in how depressed people respond to different antidepressants. The finding was made in two specific areas of the brain known to be important to depression. The study relied on microarray analysis of 32 post-mortem brain samples -- the microarray metho......naling components may underlie some of the genetic variation in human osteoarthritis risk and suggests that treatments designed to mimic or augment BMP signaling might help to maintain healthy joints....New genomic method can identify disease-causing genes
...es advantage of the block-like patterns of genomic variation in selected mouse strains, as illustrated on the c...ence in their analyses. The pattern of genetic variation analyzed by this new computational method was created by mining a database of common genetic markers......zens or even hundreds of other genes. Therefore, a variation in EN2 could have far-reaching effects on brain development and behavior. The next step in this line of research will be to show that the variations in EN2 have an effect on the transcription factor's function. "We hope that by identifying thi...GENEPI: a tool to refine and fine-tune radiotherapy treatment for cancer
...e know that there is considerable person-to-person variation in the sensitivity of normal tissues, and tumour tissues, to radiotherapy and that this sensitivity may have a genetic basis", explained Dr. Hlscher. "It is evident also that surgery, chemotherapy drugs and some rare genetic syndromes can influence s...Genetically endowed worm may substitute for rodents in some toxicology testing
...ee how fast they grow." Another variation is to create varieties of transgenic worm lines, each bearing a different gene that fluoresces green under stress. "That way in a 96-well plate each well would have a different strain of transgenic worm that could respond to a chemical," he said. "So...'Broken' gene reveals evolution of salt retention and possible ties to hypertension
...d pre-eclampsia, a complication of pregnancy. One variation of this gene, known as AGT M235, was closely correlated with CYP3A5 *3. This correlation of two unlinked gene variants with similar effects, "is remarkable," the authors note, "and suggests a shared selective pressure." The National Institutes of Hea...Plentiful fossils of dinosaur contemporary allow population study
...pace into two-dimensional plots and then looks for variation between different groups of Tanys. So far, Casey, museum vertebrate paleontology curator Nicholas Fraser, and Virginia Tech geosciences professor Michal Kowalewski have discovered there are no differences in morphology between populations of fossils...JCI table of contents November 1, 2004
...ht into the genetic changes that can contribute to variation of HDL in the general population and add to our cu...anisms relating to Tangier disease. TITLE: Genetic variation in ABC transporter A1 contributes to HDL cholesterol in the general population AUTHOR CONTACT: Anne ...Sleeping, waking, ... and glucose homeostasis
...t's more, a high-fat diet amplified this circadian variation in the normal animals, but the rhythm was abolished in the mutants on a high-fat diet. Thus, the authors demonstrated that circadian control of blood glucose levels is due directly to the presence of these transcriptional factors rather than due to s...Mutations in transporter protein effect HDL levels in the general population
...ht into the genetic changes that can contribute to variation of HDL in the general population and add to our current understanding of the variety of mechanisms that together contribute to increased or decreased susceptibility to cardiovascular disease. An accompanying commentary places this study in the conte...National Eye Institute funds search for genetic key to corneal disease
...l fund an intensive effort to pinpoint the culprit variation among possible genes on that strip of the chromosome, clarifying the molecular cause of the disease. Once treatable only by corneal transplantation, Thiel-Behnke is now treated by laser surgery but can still result in loss of vision, Yee said. In a...Genetically engineered corn poses no immediate threat to Mexican crops
...s could also be considered a new source of genetic variation for plant breeding practices." Snow was part of the Maize Advisory Group, a 16-member group established by the North American Commission for Environmental Cooperation (CEC). The CEC oversees the environmental provisions of NAFTA. Her colleagues incl...Spatial structure, dispersal, and management of a recovering raptor population
Most wild species experience considerable variation in habitat quality. Ecological theory that considers how organisms disperse between good and bad habitats has shown that such spatial structure can strongly influence population dynamics, but real-world implications have rarely been found. In this st...