New techniques redefine assessment of liver disease
... associated with insulin signaling, which leads to abnormal blood glucose levels and diabetes, leading researchers to the conclusion that "prognostic biomarkers" can be developed that can potentially predict resolution of important complications of obesity such as DM. "Recognition of specific cell signaling...Repair of DNA by Brca2 gene prevents medulloblastoma
...is quickly repaired to prevent the accumulation of abnormal cells that can cause abnormalities, such as medull...sulted in small brain size due to apoptosis of the abnormal cells. These findings showed that the mouse model closely copied the human characteristics of F...Cornell lab confirms deadly fish virus spreading to new species
...hould avoid eating any fish (or game) that appears abnormal or behaves abnormally. Not all infected fish, however, exhibit symptoms. Some may be carriers, and visible signs of the disease may vary from species to species. Containing the spread of the virus in New York will require restrictions on the movemen...Gladstone's Deepak Srivastava receives E. Mead Johnson Award for achievement in pediatrics
...ng the intricate networks that regulate normal and abnormal cardiogenesis, along with his contributions in understanding the genetic causes of human cardiac malformations. Im proud to be a part of this long tradition of excellence in pediatric science, said Dr. Srivastava. While Im very honored to receive t...Vaccine prevents prion disease in mice
...nated with prions. The disease causes dementia and abnormal limb movements. Prion is a protein that is also an infectious agent. The proteins are so similar to proteins found normally that the immune system does not fight them off. To develop a vaccine that would stimulate the mice's immune system, researc...Scientists identify new strategy for preventing acute and chronic brain disease
...ed to finding ways to specifically eliminate these abnormal forms of tau, but this has been difficult. The current study suggests that lowering overall tau levels may be a good alterative, especially since even partial tau reduction was effective and very well tolerated, at least in the mice. A breakthrough...UCSF-led team receives $15 million to study genetics of epilepsy
...people. It is characterized by seizures caused by abnormal electrical activity between nerve cells in the brain. Although it has been known since antiquity that the disorder is influenced by inherited genes, progress to date has been limited to the discovery of single gene mutations that cause the disease...New clues for treatment of disease that causes accelerated aging
...oms are linked. "It's a matter of ratios: the more abnormal protein you have, the more severe the disease," Miner says. "And apparently we don't have that far to go to tip that ratio in progeria patients' favor." Researchers at other institutions have been developing a treatment for progeria that blocks lamin...News tips from the Journal of Neuroscience
...ation-blocking morpholinos of plexinA3 mRNA caused abnormal axon branching of dorsal and ventral motor nerves, and induced exit from posterior segments of the spinal cord at additional exit points. Overexpression of plexinA3 mRNA, which did not bind the morpholino, rescued the phenotype. Branching and exitin...Chinese medicinal compound stops formation of cysts in polycystic kidney disease in lab
...on poorly. Because most patients inherit only one abnormal gene and one functional gene, the body is usually able to compensate for the faulty gene and the person retains kidney function during the 20s and 30s. But through random mutagenesis, the remaining good copy of PKD1 is lost in some cells, which then ...Tips from the Journals of the American Society for Microbiology
... elk. Conversion of the normal host protein to an abnormal disease-associated form is an important part in the tracking of prion diseases and researchers are hopeful that rodent-adapted CWD models could assist in therapeutic development. In the study transgenic and wild-type mice in addition to Syrian, Dju...News tips from the Journal of Neuroscience
...tal retardation, seizures, movement disorders, and abnormal cortical development. In this weeks Journal , Colombo et al. used mutant mice to examine the impact of Arx loss-of-function mutations on basal ganglia structures. Arx is expressed in progenitor cells and neurons of the lateral and medial ganglionic ...Stanford scientists make major breakthrough in regenerative medicine
...e ultimate medical treatment would be to change an abnormal organ or tissue back to its vibrant, normal state," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This study is a landmark in regenerative medicine; the Stanford group has accomplished the biological equivalent of turning a sows...Antioxidant found in many foods and red wine is potent and selective killer of leukemia cells
... Greek, leukemia occurs when there is an excess of abnormal white blood cells. There are both acute and chronic forms of leukemia, each with many subtypes that vary in their response to treatment. According to the National Cancer Institute, about 44,000 new leukemia cases will be diagnosed in the United State...Class of PCB's causes developmental abnormalities in rat pups
...cortex is the first sensory region to develop, its abnormal development in the rat pups could be just a hint of more pervasive effects of exposure, the scientists say. PCB95 is closely related in its chemical structure to polybrominated diphenyl ether (PBDE), which is difficult to study and has only begun t...Award lectures for ASBMB's 2007 Annual Meeting
...ells can either become cancerous or end up with an abnormal number of chromosomes a condition called aneuploidy and involved in causing cancer. Amon will describe her work on how cells become aneuploid and how her findings may provide new hints into the genetic origins of cancer. WEDNESDAY, MAY 2 Willia...World first test potential to identify breast cancer patients who will react badly to radiotherapy
...ents be sought. There is no test at present for an abnormal reaction to radiotherapy. No-one in the past has proposed such a test. The team who carried out the study included Drs Paul Symonds, Mark Plumb, Irene Peat and George Giotopoulos of the Department of Cancer Studies and Molecular Medicine and the...News tips from the Journal of Neuroscience
...eas reduced Sef expression in mutant mice caused abnormal morphological development in some, but not all, animals. Mutant mice had normal auditory thresholds but reduced auditory brainstem responses. 3. The Ups and Downs of Cortical Activity Pavlos Rigas and Manuel A. Castro-Alamancos When it comes ...JCI table of contents: April 12, 2007
...d that cardiac muscle cells from these mice showed abnormal release of calcium from a cellular compartment known as the sarcoplasmic reticulum and that the heartbeat of these mice was substantially slower than the heartbeat of normal mice. This study indicates that CaM inhibition of RyR2 is crucial for normal...... tumor cells implanted in mice have shown that the abnormal activation of four genes drives the spread of brea...u and his colleagues had identified 18 genes whose abnormal activity is associated with breast cancers ability to spread to the lungs. In the new study publishe...