Tag: "abnormalities" at biology news

Scientists making advances receive international awards

...herapy, with special emphasis on signaling pathway abnormalities in cancer cells as targets for drug therapy, will give his lecture "Molecularly targeted cancer therapy: Future challenges," at noon on Tuesday, April 19, in Hall A of the Anaheim Convention Center. Napoleone Ferrara, M.D., Fellow at Genentech, Inc. ...

Next-era targeted therapy overcoming Gleevec's shortcomings

...s," defined as a complete absence of all molecular abnormalities and a return to a normal status. "We now are beginning to see the number of cytogenetic responses climb, as well as molecular major responses," Giles says. He added that the potential success of AMN107 represents a "phenomenal rate" of drug developm...

Faulty body clock leads to obesity and diabetes

...iduals, but now we have shown that weight gain and abnormalities in metabolism, including diabetes, result if this ...ges in metabolism. The obese mice showed metabolic abnormalities in insulin secretion and the ability of the liver to handle sugar. Obesity is associated with meta...

Important brain finding results from boy's rare, fatal disease

...," says Powers, who notes that others have noticed abnormalities in the astrocytes of patients with the disease. In addition to Proschel, Torres, Mayer-Proschel, and Noble, authors of the paper include neurologist Jorg Dietrich, M.D.; technicians Michelle Lacagnina and David Gass, who devoted months to keeping th...

How the environment could be damaging men's reproductive health

...ery, small gestational weight and other congenital abnormalities of the genitalia. An interesting significant risk factor was the father's weight; babies born to underweight fathers (body mass index less than 20kg/m2) were six times more likely to have undescended testes. However, Dr Jorgensen said: "This finding ...

UI researcher studies deafness in fruit flies, humans

...derstanding how such mutations result in inner-ear abnormalities and deafness in humans. "Myosin VIIA was one of the first human hereditary deafness genes to be identified. But it is not clear exactly how this molecule works in the human ear," he says. Previous evidence suggested that fruit flies and humans rely o...

Unlocking mysteries of brain, grooming future med students goals of UH prof

...es such as Alzheimer's and schizophrenia, in which abnormalities or loss of neurons compromise brain function....

Consequences of exposure to an energy rich diet during development

...when pregnant give birth to offspring that develop abnormalities in their large arteries similar to those associated with heart disease in man. Adult offspring also showed abnormal activity of vital proteins in the kidney. We do not know what the ideal diet would be during pregnancy, however, it is clear from our...

Scientists generate patient-specific stem cells, Science study says

...ells in animal model systems indicate that serious abnormalities in human development would result if the cells were used in reproductive cloning. Any attempts at reproductive cloning would be dangerous and should not be attempted under any conditions. W.S. Hwang, B.C. Lee, S.K. Kang, D.K. Kwon, S.W. Park, H.S. Kw...

Fibromyalgia patients may benefit from cough remedy, UF study finds

...searchers have theorized that wind-up is caused by abnormalities in the spinal-cord structures that process NMDA. The UF results suggest those structures function normally but that pain impulses are more amplified in fibromyalgia than in healthy participants, Staud said. "This has refocused much of our research n...

JCI table of contents June 1, 2005

...f molecules capable of preventing these regulatory abnormalities holds the promise of eliminating the contribution of anorexia to the development of cachexia." TITLE: Role of leptin and melanocortin signaling in uremia-associated cachexia AUTHOR CONTACT: Robert Mak Oregon Health & Science University, Portland, OR...

Temple virologist receives $6.1 million NIH grant for neuro-AIDS research

...When the integrity of a cell's DNA is compromised, abnormalities such as apoptosis, or cell death, can occur," Khaili said. "So we'll be closely examining, among other things, how the virus causes this DNA repair dysfunction." While PML remains a very rare disease in individuals not infected with HIV, adds K...

Link between mothers' poor diets, kids' obesity

...impaired transport of the hormone to the brain and abnormalities in the hypothalamic brain region that governs leptin response. The findings suggest that the leptin surge may be a target for therapeutic intervention in the developmental origins of health and disease, the researchers said....

JCI table of contents July 1, 2005

...sease. Title: Functional, structural and metabolic abnormalities of the hippocampal formation in Williams syndrome AUTHOR CONTACT: Andreas Meyer-Lindenberg National Institute for Mental Health, Bethesda, MD USA Phone: 301-517-5760; Fax: 301-496-7437; E-mail: am-l@nih.gov View the PDF of this article at: https:...

New study demonstrated add-on effects of ACTOS (pioglitazone HCl)

... for cardiovascular disease, is a profile of lipid abnormalities typically seen in people with type 2 diabetes. Th...s in people who do not have diabetes, the specific abnormalities in the lipoprotein pattern characteristic of diabetic dyslipidemia appear to add excess risk for peo...

Gene variant linked to chronic kidney disease

...ease. The e2 allele is known to be associated with abnormalities in plasma triglycerides, a condition that is also common with kidney disease. Smaller previous studies have suggested that the e2 increased and e4 alleles decreased the risk of kidney disease, but those studies mostly focused on individuals with diab...

Researchers track down cause of a disfiguring bone disorder

...t regulatory elements are able to cause congenital abnormalities analogous to coding (gene) mutations." "Human genetic diseases of the skeleton such as sclerosteosis and Van Buchem disease provide a starting point for understanding the modulation of anabolic bone formation," noted team members Michaela Kneissel an...

Self-correcting embryos could be an ethically acceptable source of embryonic stem cells

...be used to study the effect of various chromosomal abnormalities on human development." Dr Munn took 50 embryos, wh...echanism by which the embryos self-corrected their abnormalities was not clear, Dr Munn believed that it probably happened when a trisomic embryo (one with three of ...

APNS sees abnormal cell division as possible precursor of Alzheimer's disease

...ant progress in determining what causes brain cell abnormalities and results in Alzheimer's disease," said Dr. Davi...believe we have identified another possible cause: abnormalities occurring in tau proteins that may activate a cascade of abnormal events. All of this takes place l...

Expert system developed to enhance diagnostic accuracy of Alzheimer's disease with FDG PET scans

...n. Based on this knowledge, the program identifies abnormalities in the PET images and detects Alzheimer's typical ...ody disease) that also show typical, but different abnormalities in the FDG-PET image," he added. This prototype research tool is not yet designed for commercial app...

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(Date:4/16/2014)... store memories improves during childhood, associated with structural ... prefrontal and parietal cortices. New research from UC ... at this crucial time. Eventually, that could give ... transition into and during adolescence and affect memory, ... in the middle of the brain, the hippocampus ...
(Date:4/16/2014)... Dr. Klaus Aktories and Dr. Panagiotis Papatheodorou from the ... the University of Freiburg have discovered the receptor responsible ... perfringens into the cell. The TpeL toxin, which ... that causes gas gangrene and food poisoning. It is ... germs of the genus Clostridium . The toxins ...
(Date:4/15/2014)... 15, 2014, Irvine, Calif. UC Irvine neurobiologists have ... results when transplanted into the brains of mice with ... trial is published in the journal Stem Cells ... shown to work in two different mouse models. ... of dementia, is associated with accumulation of the protein ...
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