Tag: "abnormality" at biology news
Zebrafish: It's not your parents' lab rat
...e said. "It develops in a very regular way, so any abnormality
is easy to spot, even for undergraduates with only a few days training."...
Metabolic syndrome -- don't blame the belly fat
... The metabolic syndrome is a very common metabolic abnormality
and the prevalence is growing. However, the underlying factors that cause it are poorly understood. The syndrome afflicts more than 50 million Americans and roughly half of all Americans are predisposed to it, making it one of the nation's most serio...
New approach to pulmonary hypertension shows promise
... Most current therapies are designed to attack one abnormality
at a time, Michelakis said, adding that this work shows for the first time that several of these abnormalities, so far considered to be unrelated to each other, may in fact be the result of a single problemactivation of NFAT. "Therefore, by attack...
Researchers find gene that spurs development of the epididymis
... fertile. The researchers first thought that the abnormality
was due to a lack of the male hormone, testosteron...parents, to see how early in their development the abnormality
appeared. She found the earliest evidence of a lack of proper coiling in the epididymis between days...
MIT researchers reverse symptoms in mice of leading inherited cause of mental retardation
...g PAK's enzymatic activity reversed the structural abnormality
of neuronal connections found in the FXS mice, said co-author Susumu Tonegawa, 1987 Nobel laureate and Picower Professor of Biology and Neuroscience. "Strikingly, PAK inhibition also restored electrical communication between neurons in the brains of ...
How genetic malfunction causes a form of retardation
...ance, they theorize, could explain how the genetic abnormality
gives rise to the neural pathology of the disorder. More broadly, they said, the new insight into the mechanism underlying NS could apply to other inherited forms of retardation. Freda Miller of the Hospital for Sick Children and University of Toro...
Genes and biomarkers that allow doctors to choose the right therapy for the right patient
...cs between breast cancers, although some recurrent abnormality
patterns are emerging that define breast cancer subtypes" said Joe W. Gray, Ph.D., staff scientist and director of the Life Sciences Division at Lawrence Berkeley National Laboratory. "We need better ways to identify how we can best tailor existing ...
Chromosomal microarray analysis proves accurate
...five to 12 percent chance that it will identify an abnormality
in children with various disabilities where the previous chromosomal testing did not. This study involved two versions of the test, and the newer version was more successful in identifying chromosomal abnormalities. The targeted microarray analysis...
Severe mental retardation gene mutation identified
...ildren better, but knowing that we found a genetic abnormality
gives them an explanation for what has happened," she explains. "We had one family that said this knowledge was the best news they had ever been given." "We have identified the cause of problems in certain families and are able to tell whether or ...
NSAIDs modulate biomarker panel for esophageal adenocarcinoma
...of DNA present. They assessed whether each genetic abnormality
was associated with the risk of developing esophag...carcinoma; over 10 years patients with no baseline abnormality
had a 12% cumulative incidence of esophageal adenocarcinoma, whereas patients with the full panel of...
Angelman syndrome deficits rescued in mice
...n the process, Weeber and colleagues identified an abnormality
in the Angelman syndrome mouse model changes in an enzyme called calcium/calmodulin-dependent protein kinase II (CaMKII), which is important in the cellular processes that underlie learning and memory. They found that, in Angelman syndrome, CaMKII...
Extreme irritability -- is it childhood bipolar disorder?
...eir frustration differed. Children with BD had an abnormality
in the brain's P3 electrical signals, which measure ability to purposefully direct attention, but children with SMD had abnormalities in N1 signals, which occur when a stimulus grabs someone's attention. Both abnormalities suggest deficits in the br...
Researchers develop new strategy for the treatment of CML
...er of the bone marrow caused by a specific genetic abnormality
and is one of the more common forms of leukemia. Imatinib mesylate (Gleevec) is a highly effective anti-cancer agent that has revolutionized the course of therapy for patients with CML. It works by inhibiting the activity of a mutant protein, known a...
White blood cells in lung produce histamine seen in allergies
...n rodents and humans. One population had a genetic abnormality
that causes a total lack of mast cells; the other population was made up of normal, wild-type mice. Both populations of infected mice developed pneumonia. "We thought the mice without mast cells would do better than the wild-type mice, because the ...
After 2 years, study shows Revlimid patients live longer and remain transfusion free
... in MDS patients with or without the chromosome 5q abnormality
and dramatically help to improve their quality of ...yndromes associated with a deletion 5q cytogenetic abnormality
with or without additional cytogenetic abnormalities. Revlimid is also used as treatment in combina...
Origin of inherited pain disorder pinpointed
...eknown to be effective in PEPDacts to correct this abnormality
in cultures of neurons. The researchers also compared PEPD with another inherited pain disorder, primary erythermalgia (PE) that is not alleviated by carbamazepine. PE is also caused by mutations in SCN9A and is characterized by pain in the extremit...
Research yields new insights into the cause of diabetes
...ent mice are physically unusual. The most obvious abnormality
is that proinsulin is found the endoplasmic reticulum, instead of being found in or around the nucleus. Apparently, proinsulin is produced as usual, but the normal modification process is blocked, leaving large quantities of proinsulin trapped insid...
Dragonfly's metabolic disease provides clues about human obesity
...on those concentrations. Insulin resistance is an abnormality
associated with metabolic syndrome in humans. The researchers found the parasites rapidly caused effects in the dragonflies. Dragonflies that drank water containing trace amounts of excretory-secretory substances obtained from live parasites showed...
Researchers identify molecule that causes destructive lung inflammation in cystic fibrosis patients
...." CF is an inherited disease characterized by an abnormality
in the body's salt-, water- and mucus-making cells... more than 430 patients. Children with CF have an abnormality
in the function of a cell protein called the cystic fibrosis transmembrane regulator. This affects t...
Carnegie Mellon uses new imaging technique to discover differences in brains of people with autism
...researchers that found for the first time that the abnormality
in synchronization among brain areas is related to the abnormality
in the white matter. They discovered that key portions of the corpus callosum seem to play a role in...
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