deCODE discovers cause of major subtype of glaucoma
...n the formation of elastin fibers which, when they accumulate in the eye, cause XFG. The paper, entitled Comm...ation syndrome, in which fibrous deposits begin to accumulate in the front of the eye but have not yet begun to impair vision. Analysis of additional SNPs in publ...Gilbert Foundation and American Fed for Aging Research award grants on Alzheimer's disease
...rch is to identify ways in which specific proteins accumulate in the brain and identify new drug targets for the treatment of Alzheimers disease. The study will focus on the removal of the accumulated proteins by manipulating a class of proteins called molecular chaperones. These chaperones help in the processi...A unique arrangement for egg cell division
... only form when the division is about to start and accumulate in the cells centre. There, the around 80 individual MTOCs start interacting in a tug-of-war of pulling and pushing each other. This ultimately leads to a self-organized spindle with two poles in which all chromosomes are accurately aligned for the s...Sugar and spice and everything nice: Health differences in newborn girls and boys
...lism) are lactate and hydrogen ions (H+) which can accumulate in the liver cells during ischemia leading to detrimental affects. Thus, to better understand the gender effects of infant liver transplantation, the researchers examined anaerobic end-product accumulation in newborn male and female livers during n...Research shows NPD1 protects a key component of vision
...ent cell death caused by an excess of A2E known to accumulate in the RPE during aging and to be exaggerated in age-related macular degeneration, the researchers added NPD1 to an A2E-induced experimental model and found it not only stopped programmed cell death, but that the protective effects were present even ...Discoverer of Sly Syndrome finds way of delivering medicine to fight rare genetic disorder
...dase. Without this enzyme, protein-sugar molecules accumulate in the brain and other organs in the body. By replacing the missing enzyme, doctors believe they can treat the genetic disease. The problem, though, was slipping the enzyme past the blood-brain barrier to where it needs to do its work. This is a di...New role for protein in fat cells may improve understanding of obesity and diabetes
... used easily. In normal cells, when these two fats accumulate in the droplets, they can be removed from the droplets and then used by the cell after the fats are broken down by enzymes called hydrolases. But since hydrolases are in the droplets and not in the ER, cells low in CETP cannot break down the fats the...MIT, BU team builds viruses to combat harmful 'biofilms'
...eth if you don't brush for a day or two. When they accumulate in hard to reach places such as the insides of food processing machines or medical catheters, however, they become persistent sources of infection. These bacteria excrete a variety of proteins, polysaccharides, and nucleic acids that together with...Neutral evolution has helped shape our genome
...otentially damaging but mostly neutral bits of DNA accumulate over time by comparing the sequences of human numts with those in different animals. How closely the different species sequences match can provide an estimate of when that particular sequence got inserted into the ancestor of the human genome. The...New way to target and kill antibiotic-resistant bacteria found
...ic survives. These drug-resistant microbes quickly accumulate useful mutations and share them with other bacteria through conjugation the microbe equivalent of mating. Conjugation starts when two bacteria smoosh their membranes together. After each opens a hole in their membrane, one squirts a single strand...Scientists gain important insights into acute promyelocytic leukemia
...oliferative and immature stage. The abnormal cells accumulate and eventually crowd out the normal, healthy blood cells. Most cases of APL are caused by the expression of the PML/RARA (promyelocytic leukemia/retinoic acid receptor alpha) oncogene. This oncogene is formed by an abnormal translocation between two ...Tiny tweezers and yeast help St. Jude show how cancer drug works
... an over-wound telephone cord. If these supercoils accumulate and persist while the cell is trying to separate the two strands of DNA to make exact copies of the chromosomes during cell division, the cells will die. Nanotechnology studies work at a scale of about 100 nanometers or less. For comparison, one n...TU Delft tracks the influence of a cancer inhibitor on a single DNA molecule
...matically impedes the unwinding and that DNA loops accumulate as a result. The accumulation of these DNA loops forms the basis for an alternative mechanism, and could help in the development of better cancer medicine. PhD candidate Daniel Koster, Masters student Elisa Bot and researcher Nynke Dekker of the M...In nature, proteins sweep up nanoparticles
...their sulfide waste product, which could otherwise accumulate and entomb the bacteria or interfere with their cellular machinery. Think of it as trash pickup at the nanoscale. Regardless, the process stops the spread of metal nanoparticles in natural environments, which is reason enough to explore it further. ...A possible mechanistic link between stress and the development of Alzheimer tangles
...plaques and neurofibrillary tangles. While plaques accumulate outside of brain cells, tangles litter the inside of neurons. They consist of a modified form of the tau protein, whichin its unmodified formhelps to stabilize the intracellular network of microtubules. In Alzheimer's disease, as well as various othe...Talcum powder stunts growth of lung tumors
...metastatic lung cancer. About half of all patients accumulate fluid around the surface of the lungs, a condition known as malignant pleural effusion. That fluid can press down upon the lung, impair the breathing of the patient and cause the patient to feel very short of breath, said Antony. Pleural effusio...Bigger horns equal better genes
...kens with age, genetic mutations have effects that accumulate over time. Therefore, differences in genetic quality become more apparent as an organism ages. Coltman noted that his study, which incorporated genetic samples from more than 150 ibex, took into account the fact that environmental factors also pla...News tips from the Journal of Neuroscience
...a prevents hydroxylation, allowing the subunit to accumulate and form active dimers with HIF-1. Mutant mice with conditional deletion of HIF-1 in forebrain neurons fared worse than wild-type (WT) mice after focal cerebral ischemia. WT mice that received pharmacological activators of HIF-1 showed further improv...Cigarette smoke alters DNA in sperm, genetic damage could pass to offspring
...posure, so the longer you smoke the more mutations accumulate and the more likely a potential effect may arise in the offspring, Yauk said. According to Yauk, previous studies have shown that Ms6-hm and similar locations of non-coding DNA are sensitive to damage from radiation, mutagenic chemicals and intens......icals that carry cholesterol and fats in the blood accumulate in people with type 2 diabetes, which may help imp...r obese people, nutrients leak from fat tissue and accumulate in other organs, fat tissue releases abnormal quantities of biochemicals, and the distribution of fa...